CDC reports on hospitalization and deaths among breakthrough cases

Posted on by Jesse Santiano, M.D.

The COVID-19 Vaccine Breakthrough Case Investigation and Reporting webpage of the CDC has a report that everyone should see.

Vaccine breakthrough cases are vaccinated people who got Covid 19.

The CDC shows that 94% of breakthrough cases are hospitalized. 20% of the hospitalized patients die. Are we seeing evidence of antibody-dependent enhancement here?

20% of deaths among the COVID-19 breakthrough cases is high.

There is a footnote (†) on the Deaths that says,

†316 (21%) of 1,507 fatal cases reported as asymptomatic or not related to COVID-19.

Even if 316 is subtracted from 1,507 there is still 1,191 deaths that makes up 15.8% (1,191/7,525 total deaths).

To their credit, CDC also mentioned that the numbers above might be higher than reported. Highlights are mine.

How to interpret these data

The number of COVID-19 vaccine breakthrough infections reported to CDC likely are an undercount of all SARS-CoV-2 infections among fully vaccinated persons.

National surveillance relies on passive and voluntary reporting, and data might not be complete or representative. These surveillance data are a snapshot and help identify patterns and look for signals among vaccine breakthrough cases.

Take away message

Vaccination is not 100%. Continue to take precautions.

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