Moderna Booster Lot Numbers with the Most Reported Deaths: A First Look

Part 3 of the Vaccine Lot Numbers Examined

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Introduction

This is the first article on DrJesseSantiano.com examining Moderna COVID-19 booster shots and reported deaths following vaccination. It is the third installment in our VAERS Data Series, following our analyses of original Pfizer and original Moderna monovalent lots.

The data presented here is current as of April 24, 2026, drawn directly from the U.S. Vaccine Adverse Event Reporting System (VAERS) — a national passive surveillance database co-managed by the CDC and FDA.

Unlike our previous articles, which focused on the original monovalent vaccines (COVID-19 product code), this article examines Moderna bivalent boosters (product code COVID-19-2), which began distribution in October 2021.

Important Context: Why Booster Death Reports Are So Much Lower Than Original Series

Vaccine TypeTime PeriodTotal Death Reports (VAERS)Key Population
Original Moderna2020–20218,374Elderly, nursing home residents, highest-risk
Moderna Bivalent Booster2022–2024112Younger, healthier, prior immunity

The most vulnerable individuals — those at highest risk of death from any cause — were vaccinated in 2020 and 2021. By the time bivalent boosters rolled out in late 2022:

  • Many high-risk individuals had already died (from COVID, age, or underlying conditions)
  • The remaining population was generally younger and healthier
  • Many people had prior infection or vaccination, providing some immunity

This does not mean boosters are safer. It means the population receiving boosters had a much lower baseline risk of death. Comparing raw death counts between original series and boosters is invalid without adjusting for age, health status, and time at risk.

ALT_TEXT -Infographic explaining why Moderna booster death reports (112) are much lower than original Moderna series (8,374). Three factors: healthier population receiving boosters, reporting fatigue (people stopped filing reports by 2022), and different vaccine formulation. Concludes that the drop is not proof boosters are safer. DrJesseSantiano.com centered at bottom.
Fig. 1: The drop from 8,374 to 112 death reports does not prove boosters are safer. Three factors explain the difference — and VAERS cannot separate them.

Summary of Key Caveats (Same as in the Primary Pfizer and Moderna Shots)

What these numbers AREWhat these numbers ARE NOT
Reports of death after Moderna booster vaccinationProof of death because of the booster
Useful for generating hypothesesUseful for determining safety or risk
A reflection of reported volumeA reflection of actual death rates
Known to capture fewer than 1% of eventsA complete or accurate count

The Attribution Problem: Booster vs. Original Series

When a person who received:

  • Original Moderna primary series (2021)
  • Moderna bivalent booster (2022 or later)

Experiences a serious adverse event or death, VAERS typically records only the most recent lot (the booster). However, the event could be related to:

  • The booster itself
  • The original primary series (with delayed onset)
  • An interaction between doses
  • Purely coincidental background illness

VAERS cannot distinguish between these possibilities. This is especially important for booster data, because nearly everyone receiving a booster also received at least two prior doses.


The Lazarus Report: Underreporting Still Applies

As noted in our previous articles, the Lazarus Report (AHRQ Grant No. R18HS017045) found that:

“Fewer than 1% of vaccine adverse events are reported to VAERS.”

This means the 112 death reports in this dataset likely represent only a small fraction of actual deaths that occurred after the Moderna booster vaccination. The true number is unknown but almost certainly higher.


Reporting Fatigue: A Critical Additional Factor

By the time Moderna bivalent boosters rolled out in late 2022, the U.S. had been vaccinating against COVID-19 for nearly two years. Millions of doses had been administered. The media frenzy over vaccine side effects had subsided. And people — including healthcare providers — were simply tired of reporting.

This phenomenon is called reporting fatigue. It is a well-documented limitation of passive surveillance systems like VAERS.

Why Reporting Fatigue Matters for Booster Data

FactorImpact on VAERS Reporting
Pandemic fatigueBy 2022, many people were exhausted by COVID-19 news and stopped filing reports
Provider burnoutHealthcare workers, overwhelmed by the pandemic, had less time for voluntary reporting
Diminished media attentionDeaths after boosters received far less news coverage than deaths after primary series
Perceived “old news”Reporters and the public assumed vaccine safety was already settled
No noveltyThe first vaccine deaths were shocking; by the third or fourth dose, they were not

What This Means for the Numbers

Even if Moderna boosters had the exact same underlying risk as the original Moderna series, we would expect to see far fewer VAERS reports simply because people stopped reporting.

In other words:

The drop from 8,374 death reports (original Moderna) to 112 death reports (Moderna boosters) is likely due to a combination of:

  1. A healthier vaccine recipient population (fewer background deaths)
  2. Reporting fatigue (fewer reports filed)
  3. Possibly, but not necessarily, a safer vaccine

VAERS cannot tell us which factor is most important. The data does not separate these effects.

ALT_TEXT - Infographic showing a timeline from 2020 to 2024 with a downward trend. 2020: high reporting rates due to media attention. 2021: VAERS reports peak. 2022: pandemic fatigue sets in, reporting drops. 2023-2024: even fewer reports filed. Concludes that fewer reports in later years does not mean fewer adverse events — it means fewer people reported.
Fig. 2: Reporting fatigue means later VAERS data is less complete. Fewer reports does not equal fewer events — it equals fewer people reporting.

Top 100 Moderna Booster Lots by Total VAERS Death Reports

The table below ranks Moderna bivalent booster lots by the total number of death reports in VAERS (all reports combined). These are raw, unverified counts. See the limitations above before drawing any conclusions.

RankVaccine LotTotal Death Reports
1AS7144B6
2AS7165B5
3020H22A5
4NONE17
5AS7148B4
6AS7145B4
7AS7162B4
8AS7180B4
9AS7184B4
10021H22A4
11050D22A4
12055F22B4
13061F22A4
14AS7146B3
15AS7164B3
16015H22A3
17016H22A3
18049D22A3
19062F22A3
20067H22A3
21AS7143C2
22AS7147B2
23AS7163B2
24AS7166B2
25AS7167B2
26AS7172B2
27010H22A2
28013H22A2
29014H22A2
30019H22A2
31027E22A2
32041H22A2
33042H22A2
34043H22A2
35045H22A2
36057F22A2
37058A22-2A2
38059F22A2
39066H22A2
40207F23A2
41208F23-2A2
4230303722
4306F22A2
44AS7148C1
45AS7150B1
46AS7151B1
47AS7152B1
48AS7153B1
49AS7154B1
50AS7155B1
51AS7156B1
52AS7157B1
53AS7158B1
54AS7159B1
55AS7160B1
56AS7161B1
57AS7168B1
58AS7169B1
59AS7170B1
60AS7171B1
61AS7173B1
62AS7174B1
63AS7175B1
64AS7176B1
65AS7177B1
66AS7178B1
67AS7179B1
68AS7181B1
69AS7182B1
70AS7183B1
71AS7185B1
72011H22A1
73012H22A1
74017H22A1
75018H22A1
76021A22A1
77021H22B1
78022H22A1
79023H22A1
80024H22A1
81025H22A1
82026H22A1
83028H22A1
84029H22A1
85030G22B1
86031H22A1
87032H22A1
88033H22A1
89034H22A1
90035H22A1
91036H22A1
92037H22A1
93038H22A1
94039H22A1
95040H22A1
96044H22A1
97046H22A1
98047H22A1
99048H22A1
100050122A1

Note: Lots with identical totals are ranked alphabetically within the same count. The NONE category (missing lot number) had 17 reports.


What This Table Actually Shows

If you think it shows…The truth is…
The most dangerous Moderna booster lotsThe most widely used Moderna booster lots (e.g., AS7144B, AS7165B, 020H22A)
A safety signalreporting signal (higher volume lots naturally have more reports)
That boosters are safer than original seriesBoosters were given to healthier people with lower baseline death risk
Proof of vaccine harmProof that VAERS captures coincidental deaths
Complete reporting of all adverse eventsReporting fatigue means many events went unreported by 2022–2024

Notable Observations

  1. AS7144B is the highest-ranked lot with 6 death reports — a very small number compared to original Moderna lots (which had dozens or hundreds).
  2. The top 20 lots account for the majority of reports (approximately 60 of the 112 total).
  3. Many lots have only 1 report — this is typical for a vaccine distributed widely across thousands of lots.
  4. No Moderna booster lot has been recalled or flagged as unsafe by the CDC or FDA based on VAERS data.
  5. Reporting fatigue likely means the true number of adverse events is higher than even the underreporting rate would suggest, because reporting rates dropped over time.

The Bottom Line: Lessons Continue

The COVID-19 pandemic has taught us many lessons — not all of them from mainstream medicine. This first look at Moderna booster data reinforces several truths:

  1. Raw VAERS counts cannot be compared across time because the populations changed dramatically.
  2. Boosters have far fewer death reports — but that does not prove they are safer. The recipients were healthier.
  3. Attribution is impossible from VAERS alone. A death after a booster may not be caused by the booster.
  4. Underreporting means the true number of adverse events is higher than what VAERS captures.

People should look back and learn from what happened — because it can possibly happen again. Better data systems, better denominators, and better transparency are needed before the next pandemic.

Data Source and Methodology

  • Data source: CDC WONDER VAERS database
  • Query date: May 19, 2026
  • Filter: Moderna bivalent booster (COVID-19-2), U.S. reports only, symptom = DEATH
  • Processing: Reports processed through April 24, 2026
  • Total events: 112 unique death reports
  • Limitation: File grouped by VAERS ID, not by lot number; lot-level ranking not possible from this file

Don’t Get Sick!

About Dr. Jesse Santiano, MD

Dr. Santiano is a retired internist and emergency physician with extensive clinical experience in metabolic health, cardiovascular prevention, and lifestyle medicine. He reviews all medical content on this site to ensure accuracy, clarity, and safe application for readers. This article is for educational purposes and is not a substitute for personal medical care.

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Related:

References:

  • United States Department of Health and Human Services (DHHS), Public Health Service (PHS), Centers for Disease Control (CDC) / Food and Drug Administration (FDA), Vaccine Adverse Event Reporting System (VAERS) 1990 – 04/24/2026, CDC WONDER On-line Database. Accessed at http://wonder.cdc.gov/vaers.html on May 19, 2026 6:27:59 PM
  • Lazarus, R. (2010). Electronic Support for Public Health – Vaccine Adverse Event Reporting System (ESP: VAERS) – Final Report (Grant No. R18 HS017045). Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services.

Disclaimer:
This article is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician before making health decisions based on the TyG Index or other biomarkers.

© 2018 – 2026 Asclepiades Medicine, LLC. All Rights Reserved
DrJesseSantiano.com does not provide medical advice, diagnosis, or treatment


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