Laboratory Study Shows Nattokinase Can Break Down Spike Protein Fragments

This article was updated on November 21, 2025 with Spanish and Chinese audio, updated visuals, and improved explanations to reflect the most current understanding of the topic.

About the Author
Jesse Santiano, M.D., is a retired physician specializing in internal medicine and emergency medicine. He now focuses on preventive health education and evidence-based analysis of emerging biomedical research. This article summarizes peer-reviewed findings and is for informational purposes only.

Medical Disclaimer
This article reviews scientific research on nattokinase and spike protein degradation. These findings come from laboratory studies and are not proven clinical treatments. Supplements like nattokinase can interact with medications and medical conditions. Always consult a licensed healthcare professional before using any supplement.

Mandarin audio has been added to this article on November 20, 2025.

English audio below. Press play to listen

🎧 Introducción en audio — Español (Latinoamérica)

En este episodio hablaremos de un estudio científico que analizó la enzima nattokinasa, un compuesto natural presente en el alimento japonés llamado natto. Investigadores evaluaron cómo esta enzima puede interactuar con la proteína Spike del virus SARS-CoV-2 en condiciones de laboratorio. Discutiremos qué encontraron los estudios, qué significan estos resultados y qué cosas todavía no se saben. Esta información es educativa y no reemplaza el consejo médico profesional.

🎧 简短中文音频导读

以下是《纳豆激酶可分解 SARS-CoV-2 刺突蛋白》的中文导读。

研究人员发现，来自纳豆的天然酶——纳豆激酶，在体外实验中能够分解新冠病毒的刺突蛋白，而不会伤害细胞。虽然这些发现还需要更多临床研究验证，但为了解刺突蛋白的降解机制提供了重要线索。

This article is about nattokinase, another over-the-counter substance that was shown to break down the spike protein of the SARS-CoV-2 virus. Nattokinase is from natto, a fermented soybean dish popular in Japan.

The authors of the Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 are from Josai University in Saitama, Japan. It is peer-reviewed and published in the journal Molecules.

Nattokinase

A bacterium in natto called Bacillus subtilis var. natto produces nattokinase. Nattokinase promotes the dissolution of blood clots by inactivating plasminogen activator inhibitor-1 and increasing fibrinolysis. It has the highest clot-dissolving potency among anticoagulants.

In the study, cells transfected with SARS-CoV-2 spike proteins were incubated with nattokinase. After incubation with nattokinase, the spike proteins were degraded. More importantly, the transfected cells were not damaged.

Uses

These findings are promising not only for the prevention and treatment of COVID-19 but also for Long COVID.

The ability of nattokinase to degrade spike proteins may be helpful to those who have problems after their COVID vaccine. The mRNA in the shots is reverse-transcribed as part of the human DNA.

• LINE 1 can make spike mRNA become part of the human DNA
• Polymerase Theta can Change RNA to DNA
• Pfizer COVID shot makes human liver cells produce SARS-CoV-2 spike DNA

The spike protein can last in the body for months after the infection and after the shots.

• Spike proteins in the blood for two days and lymph nodes for sixty days post-COVID vaccination
• Japanese TV: Spike Proteins from Pfizer COVID shot found in the Skin
• Spike Proteins found in Shingles Lesions that Lasted for Three Months after the Pfizer shot

Spike proteins continue to elicit an immune response, which also affects the host. Nattokinase is known to be an effective anticoagulant.

• 13 ways that the SARS-CoV-2 spike protein causes damage
• Four ways the spike protein rapidly forms blood clots resistant to breakdown
• Two More Ways the Spike Proteins Produce Abnormal Blood Clots
• The SARS-CoV-2 spike protein can form amyloids seen in lung, blood, and nervous system disorders

Nattokinase is the second substance I know of that can potentially remove the problematic spike proteins from the body. Yesterday I wrote,

Bromelain and Acetylcysteine Combined Destroy SARS-CoV-2 spike protein

Nattokinase is available on Amazon. The most reviewed, witha  more than four-star rating and priced reasonably, is Doctor’s Best Nattokinase

Nattokinase is anti-atherosclerotic, lipid-lowering, antihypertensive, prevents blood clots, protects the brain, and dissolves fibrin.[2] Thus, it can lower both cardiovascular risk factors and COVID-19 risk.

Research Limitations
The degradative effects of nattokinase on SARS-CoV-2 spike proteins were demonstrated in vitro, meaning inside laboratory conditions. In-vitro results do not automatically translate into clinical effectiveness in humans. More clinical trials are needed to determine dosage, safety, and real-world benefits.

Warning

People who take another blood thinner like warfarin, rivaroxaban,  apixaban, betrixaban, edoxaban, and dabigatran should not take nattokinase because it can increase the risk of bleeding. 

People with new injuries, external or blunt trauma, and head injuries should not take nattokinase due to the risk of bleeding.

Pregnant women should consult their doctors before taking nattokinase. Generally, it is always recommended to talk to your doctor before starting any supplements.

Safety Considerations
Nattokinase has blood-thinning effects. People taking prescription anticoagulants — including warfarin, rivaroxaban, apixaban, edoxaban, betrixaban, or dabigatran — should not use nattokinase due to the risk of bleeding. Individuals with recent trauma, planned surgery, pregnancy, or chronic medical conditions should seek medical advice before supplement use.

Evidence-Based Summary

Early peer-reviewed studies suggest nattokinase can degrade SARS-CoV-2 spike proteins in controlled laboratory settings. These results are scientifically interesting but require human trials before any medical claims can be made. Readers should treat this information as scientific background and consult with healthcare professionals before using it.

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Related:

1. Bromelain for Long COVID and Post-Vaccine Syndrome
2. Bromelain and Acetylcysteine Combined Destroy SARS-CoV-2 spike protein
3. Nattokinase Degrades the SARS-CoV-2 Spike Protein
4. Another Study shows Nattokinase can Destroy the S1 Spike Protein
5. The Outstanding Vascular Effects and Dose of Nattokinase
6. Intermittent fasting results in new and stress-resistant blood cells
7. Intermittent fasting for Post-COVID Vaccine Syndrome: Autophagy
8. The I-RECOVER Post-Vaccine Treatment Protocol
9. The I-RECOVER Management Protocol for Long Haul COVID-19 Syndrome
10. Over-The-Counter Ivermectin
11. High-Dose Nattokinase to Shrink Atherosclerosis and Lower Blood Lipids

References:

1. Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005.
2. Chen H., McGowan E.M., Ren N., Lal S., Nassif N., Shad-Kaneez F., Qu X., Lin Y. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomark. Insights. 2018;13:1177271918785130. doi: 10.1177/1177271918785130

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