Disseminated SARS-CoV-2 autopsy findings in breakthrough cases explained

This article continues Autopsy findings in 29 breakthrough cases, shows what’s wrong with the COVID shots Part 1, and offers several explanations of why viral dissemination happened.

Part 1 is about a study of 29 vaccinated patients who had breakthrough infections that died and had an autopsy. The findings surprised the pathologist as they showed high viral loads, widespread dissemination of the virus, and bacterial and fungal superinfections.

Vaccinated individuals should have protection against COVID-19 because of the production of neutralizing anti-spike antibodies and T-cell responses. What happened to these patients?

The study’s authors explained that most patients are immune-compromised, making the vaccines ineffective. Twelve have a cancer history, three take immune-suppressive drugs, one has no spleen, and three have low antibodies.

However, a study from the UK entitled Cellular and humoral responses to SARS-CoV-2 vaccination in immunosuppressed patients showed that double-vaccinated patients receiving immunosuppression could produce the same levels of antibodies as the ones who are not on immune-suppressive drugs.

Likewise, it cannot be the age or presence of other medical problems since those characteristics are the same in the non-breakthrough autopsies.

The following are why there are high viral loads, viral dissemination, and superinfections.

Mechanisms of viral dissemination

1. Spike-protein vaccine-induced disease

The journal Circulation Research published a peer-reviewed study, SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. In the study, a pseudovirus was made by combining the spike protein of the SARS-CoV-2 with another virus. The pseudovirus cannot replicate.

The pseudoviruses with the spike protein were then injected into animals. Evaluation of the lungs and blood vessels of the animals showed damage similar to a SARS-CoV-2 infection. This study proves that the spike protein by itself is enough to cause symptoms exactly like COVID. The highly respected Salk Institute wrote about that study here.

The Pfizer and AstraZeneca vaccines contain the genes of the SARS-CoV-2. Once injected, the human body makes the spike protein, and the spike protein then elicits an immune response. But there is a problem. The spike protein stays around and can cause damage to the blood vessels and the lungs.

That could be the reason why some of the autopsied cases developed COVID-19 symptoms within days after vaccination. Five out of sixteen partially vaccinated people became symptomatic with COVID-19 less than one week after the vaccination. One person had COVID symptoms after the vaccination! You can see that at the table below from the paper.

People with any symptoms are prohibited from getting vaccinated. This means all who got the shot were asymptomatic at the time of infection. They sought vaccination can also mean that they are conscious and most likely know that they should stay away from people with COVID symptoms. Did they get sick from the spike protein that their body made from the vaccine?

2. Defective immune response due to spike protein

The peer-reviewed journal, Viruses, published SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. The study showed that the spike protein damages the DNA repair system, resulting in ineffective antibody formation and cancers in the future. You can read the whole explanation at Study: SARS-CoV-2 Spike Proteins Impaired DNA Repair That Can Lead to Defective Immunity and Cancers.

In the autopsy study,

Five of these cases revealed high anti-spike titers (> 2500 U/ml) while others showed only moderate levels (154 to 407 U/ml). In the remaining two cases, no antibodies against the spike protein were detected.

Therefore, despite the high and moderate anti-spike antibodies in the autopsied cases from their vaccination, their immune system could not contain the infection.

If a vaccinated individual gets a breakthrough infection, their vaccination enables them to have antibodies against the spike protein. More than that, they should be able to make antibodies towards the other proteins of the SARS-CoV-2 like the nucleocapsid protein.

In the autopsy, six fully vaccinated cases did not produce anti-nucleocapsid antibodies, and all of them had generalized viral dissemination. This could be from the DNA damage they sustained from their vaccination that debilitated their immune system, and that is why they cannot produce effective antibodies against new infections.

In contrast, natural immunity against COVID-19 will produce antibodies to all the proteins, including the variants.

3. Antibody-dependent enhancement

The purpose of vaccination is to get the immune system ready ahead of potential exposure to a germ.

The neutralizing antibodies from vaccination block the spike protein of the SARS-CoV-2 from attaching to the ACE2 receptors. If there is no viral attachment, there is no viral entry and reproduction, and the absence of replication means the disease gets prevented.

Several studies have shown that as months pass by after the vaccination, neutralizing antibodies decrease after several months. The most recent evaluation showed that mRNA vaccination is only effective for 90 days, discussed here. Study: Pfizer COVID shots are good for 90 days only.

As neutralizing antibodies decrease, non-neutralizing antibodies predominate. Non-neutralizing antibodies can also fight infection, but some may facilitate illness.

In antibody-dependent enhancement (ADE), the non-neutralizing antibodies permit the SARS-CoV-2 viruses to enter the cells of the immune system and destroy their ability to counter infections instead of blocking viral entry.

Once inside, the viruses rapidly multiply and spread to infect cells and organs all over the body. One mechanism of antibody-dependent enhancement (ADE) is the most likely reason for viral dissemination in breakthrough cases.

The image below shows antiviral antibodies containing the viruses. In ADE, the antibodies facilitate viral entry to the immune system cells like the monocytes, macrophages, B cells, and dendritic cells.

In summary, ADE does two things to make the infection worse. It makes the frontline defenses useless and allows viral dissemination.

ADE has been demonstrated several times before when vaccines against the Middle Eastern Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) were being developed. The animals developed immunity after vaccination, but when exposed to other coronaviruses, the animals died due to ADE.

That’s the reason why there are no vaccines against MERS and SARS.

4. ivermectin and Vitamin D3 not given

According to the German national treatment guidance for hospitalized COVID-19 patients. Monoclonal antibodies, anticoagulation, and tocilizumab can be given, but “Convalescent plasma, azithromycin, ivermectin or vitamin D₃ should not be used in COVID-19 routine care.”

Ivermectin effectively treats COVID-19, and adequate Vitamin D3 prevents serious COVID-19.

You can read about Ivermectin and vitamin D3

It is sad to see that people have to die because of the COVID vaccines. If they allow Ivermectin to be used, there will be no need for the jabs.

Don’t Get Sick!

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References:

Hirschbuehl et al. High viral loads: what drives fatal cases of COVID-19 in vaccinees? an autopsy study. medRxiv 2021.12.03.21267155; doi: https://doi.org/10.1101/2021.12.03.21267155
Hirschbühl et al. Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach. PLoS One. 2021 Jul 19;16(7):e0254872. doi: 10.1371/journal.pone.0254872. PMID: 34280238; PMCID: PMC8289110.
Lei et al. SARS-CoV-2 Spike Protein Impair Endothelial Function via Downregulation of ACE 2. Originally published31 Mar 2021 https://doi.org/10.1161/CIRCRESAHA.121.318902. Circulation Research. 2021;128:1323–1326
Jiang H, Mei YF. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021;13(10):2056. Published 2021 Oct 13. doi:10.3390/v13102056
Malin et al. Key summary of German national treatment guidance for hospitalized COVID-19 patients : Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021). Infection. 2021 Jul 6:1–14. doi: 10.1007/s15010-021-01645-2. Epub ahead of print. Erratum in: Infection. 2021 Aug 19;: PMID: 34228347; PMCID: PMC8259552.

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