This article discusses the step-by-step approach I will take if I want to take nattokinase, bromelain, or N-acetylcysteine to get rid of the spike proteins in the body.
After reading the following articles, some readers have been asking about the dose of nattokinase, bromelain, and NAC.
- Nattokinase Degrades the SARS-CoV-2 Spike Protein
- Another Study shows Nattokinase can Destroy the S1 Spike Protein
- Bromelain and Acetylcysteine Combined Destroy SARS-CoV-2 spike protein
If you are reading this, you probably know that the mRNA of the SARS-CoV-2 spike proteins can be reverse-transcribed and integrated into the human genome. It can happen due to COVID-19 or the COVID shots, particularly the mRNA (Pfizer and Moderna) and possibly the vector-based shots. (AstraZeneca and Johnson and Johnson)
SARS-CoV-2 RNA Reverse Transcribed to Human DNA
Once the spike protein is in the body for a long time, it can induce several bodily reactions against it.
13 ways that the SARS-CoV-2 spike protein causes damage.
As for housekeeping, please, do not consider this a physician-to-patient recommendation. I do not provide medical advice, diagnosis, and treatment on this website. (That sounds weird with everything I write, but that sentence should be here.)
Everyone has a different way of handling supplements. Differences in weight, body fat, liver and kidney functions, and physical activity account for those. That is why one dose may not be suitable for all.
Here are the steps.
A. Talk to your doctors
Before starting any nutritional supplements, always talk to your doctors, including the specialists like endocrine, kidney, and cancer doctors. They may be prescribing medicines for you that are specialty drugs like chemotherapies.
Talking to your doctor about your symptoms may prompt them to order some tests to rule out other diagnoses. Not all conditions are related to spike proteins.
Not all medical providers are familiar with nutraceuticals. Be prepared to share some information. You can refer them to my articles and tell them they include study references with links.
B. Any contraindications?
If I have any previous allergies to nattokinase, bromelain, and NAC, I won’t take it. If I have a bleeding disorder, I won’t take them.
In general, no supplements are recommended for pregnant women. For children, ask their pediatricians.
C. Will they interact with my medications?
Nattokinase
Be careful if taking blood pressure medicines. It may decrease blood pressure.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Am I taking any medications that slow blood clotting? (Anticoagulant / Antiplatelet drugs)
Nattokinase can decrease blood clotting. Taking nattokinase with blood thinners increases the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Nattokinase can increase insulin sensitivity and make some medicines for diabetes more effective. The result will be hypoglycemia or low blood sugar. Make sure you monitor your blood sugar and know the symptoms of low blood sugar.
If hypoglycemia happens, some of the diabetes drugs may need to have their dose decreased.
Bromelain
Bromelain can increase the absorption of antibiotics like amoxicillin and tetracyclin and drugs like demeclocycline (Declomycin) and minocycline (Minocin). While that can make them more effective at that dose, it also amplifies their side effects.
Like Nattokinase, bromelain can also increase thin blood. Be careful when taking antiplatelets of anticoagulants.
NAC might disrupt blood clotting and lower blood pressure. NAC with nitroglycerine, indicated in those with coronary artery disease, might cause low blood pressure and severe headaches.
N-acetylcysteine
NAC might disrupt blood clotting and lower blood pressure. Taking NAC with nitroglycerine or isosorbide (used to treat chest pain) might cause low blood pressure and severe headaches.[4]
Taking NAC with other blood pressure-lowering drugs can lower the blood pressure too much and cause dizziness and syncope.
Drugs.com lists the following interactions. Charcoal, ifosfamide (cancer drug), and NAC can affect inhaled and rapid-acting insulin absorption.
D. Record the baseline symptoms
Establishing a baseline helps guide the dosing. Write how bad the symptoms are regarding timing, frequency, and duration.
Let’s take brain fog, for example. Is it every day? How many hours a day?
If there is pain, how bad is the pain? Use the pain scale below.
If there is limited joint motion, like a shoulder, take a photo of yourself doing the maximum range of motion that it can do. Or mark on the wall how high the fingers can go with an outstretched hand.
How hard is it to put on clothes?
How many steps can you take before stopping due to pain?
Record the baseline. Start a journal with a notebook or digitally with a computer or phone with the date, symptoms, and description regarding timing, frequency, and duration.
Another way to monitor the progress will be how much you eat and sleep.
Is there any discoloration of the skin? A photo is better than a verbal description.
If there are any changes once the supplements are started, note them. Take another photo too.
E. Start with a low dose
Start with the dose that is marked on the bottle. Nattokinase is usually 100 mg or 2,000 FU (Fibrin Units), and it has anticoagulant effects at this dose.
For bromelain, it is usually 500 mg once or twice daily. Please do not take it with food.
N-acetylcysteine (NAC) for supplements typically starts at 600 mg. Depending on the manufacturer.
Nattokinase can be used alone. the NAC and bromelain were used together in the study.
F. Monitor
Check the blood pressure to make sure it is not too low or getting high. If it is getting low, ask permission before changing the dose or stopping drugs.
Don’t stop beta-blockers like metoprolol or atenolol suddenly. A rapid heart rate may result and lead to an emergency room visit.
If taking diabetes medicines, monitor the blood sugars using a glucometer.
Pay attention to any blood work results, especially the liver (ALT, AST) and kidney functions (BUN, Creatinine), to know if there will be problems. I don’t anticipate any, but it is good to know.
The fasting blood sugar and hemoglobin A1c may decrease for those taking nattokinase for those with diabetes. Thus, some drug dosages may need adjustment or discontinuation.
G. Changing the dose
If the starting dose works, I will stay with the dose, and I’ll make sure to enter in the journal the improvement.
I will wait a week or two to see if there will be an improvement. If none and I want to continue, I will increase or double the dose.
If side effects happen, it may be a sign to stop the supplement.
Maximum doses
There are no studies on the dose of NAC, bromelain, and nattokinase for spike proteins, and I will base the maximum amount on previously used doses.
NAC
The University of Michigan Health has recommended NAC for different conditions. I list them here as a guide. UM did not list it for spike proteins.
- NAC 400 to 600 mg daily for bronchitis
- COPD, 200 mg three times a day
- Angina, 600 mg thrice daily (under doctor’s supervision)
- Gastritis, one gram daily
- Neuropathy, 1,200 mg daily.
Bromelain
Bromelain is commonly prescribed at 200-2,000 milligrams daily.
A study published in Frontiers in Nutrition used a combination of nutraceuticals that included bromelain. Fifty-one patients participated and took the following twice a day with food.
- β-caryophyllene (40 mgPregnenolone 40 mg
- Dehydroepiandrosterone (DHEA) 30 mg
- Bromelain (2400 GDU*/g) 416 mg
- St. John’s Wort extract 150 mg
- Boswellia Serrata gum/resin extract (AKBA) 100 mg
- Quercetin (Sophora Japonica) 40 mg
- Zinc (as Zinc Picolinate) 12 mg
- Vitamin D25 μg (1000 IU)
Their symptoms which included fatigue, weakness, cardiac and neurological symptoms, shortness of breath, gastrointestinal disorders, ageusia or anosmia, anxiety, joint pain, rash, cough, and insomnia, got better after two weeks, with more improvements after four weeks.[6]
Nattokinase
The typical dose for nattokinase is 2,000 FU or 100 mg. The quantity in a small trial that decreased atherosclerosis was 6,000 FU daily.
In another study, more than one thousand patients used 13,800 FU daily. Nattokinase was found to have no toxicity, including genotoxicity, and has a high margin of safety. I discussed the studies that made those discoveries at:
- The Outstanding Vascular Effects and Dose of Nattokinase
- High-Dose Nattokinase to Shrink Atherosclerosis and Lower Blood Lipids
- Nattokinase is Nontoxic with a High Safety Margin
Once the bottle is consumed and there are no changes, it may not be worthwhile to continue.
H. Let me know your experience
We don’t know if human studies will be done that will show that nattokinase, NAC, and bromelain is effective against Long COVID or Post vaccine syndrome, but you can help.
If you have taken the supplements, let me know what happened, whether it is positive or not.
Relevant data to include are age, sex, type of COVID shots and how many, symptoms and descriptions, doses of the supplements, and how long it took before any improvement occurred.
Example: 60-year-old male, two doses of Moderna, leg discoloration (purple), Nattokinase at 2,000 twice daily. It improved after two weeks.
The information will be put together and reported here. Others may find that valuable. Historically, that is how medicine was practiced before. There was no reliance on big pharma to conduct their studies, which had conflicts of interest.
Where to buy: Contains Amazon affiliate links.
- Bromelain Doctor’s Best 3000 GDU
-
Doctor’s Best Nattokinase – 2, 000 FU of Enzyme – this formulation is NSK-SD with no vitamin K2. Vitamin K2 counters the effect of warfarin.
-
Best Naturals Nattokinase, 2000 FU, 100 Mg, 90 Vegetarian Capsules – This has vitamin K2 that is good for cardiovascular and bone health.
- NAC Supplement N-Acetyl Cysteine (1,000mg Per Serving, 500mg Per Cap, 210 Capsules) (Third Party Tested, Manufactured in The US)
Don’t Get Sick!
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Other solutions:
- Intermittent fasting results in new and stress-resistant blood cells
- Intermittent fasting for Post COVID Vaccine Syndrome: Autophagy
- The I-RECOVER Post-Vaccine Treatment Protocol
- The I-RECOVER Management Protocol for Long Haul COVID-19 Syndrome
- Over The Counter Ivermectin
- Bromelain for Long COVID and Post Vaccine Syndrome
- High-Dose Nattokinase to Shrink Atherosclerosis and Lower Blood Lipids
- Bromelain and Acetylcysteine Combined Destroy SARS-CoV-2 spike protein
- Nattokinase Degrades the SARS-CoV-2 Spike Protein
- Another Study shows Nattokinase can Destroy the S1 Spike Protein
- Over the Counter Ivermectin
References:
- Rxlist Nattokinase
- RX list Bromelain
- Taniguchi-Fukatsu, A., Yamanaka-Okumura, H., Naniwa-Kuroki, Y., Nishida, Y., Yamamoto, H., Taketani, Y., & Takeda, E. (2012). Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity, lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance. British Journal of Nutrition, 107(8), 1184-1191. doi:10.1017/S0007114511004156
- NIH Health Information Nattokinase
- The University of Michigan Health N-acetyl cysteine
- Gaylis NB, Kreychman I, Sagliani J, Mograbi J, Gabet Y. The results of a unique dietary supplement (nutraceutical formulation) used to treat the symptoms of long-haul COVID. Front Nutr. 2022 Oct 25;9:1034169. doi: 10.3389/fnut.2022.1034169. PMID: 36386945; PMCID: PMC9641293.
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If you take either or both Nattokinase and Bromelain at the same time as NAC wouldn’t the enzymes just break down the NAC?
According to the ones who made the study that combined the NAC and Bromelain, Bromelain did not break down the NAC. The NAC can also avoid the digestive enzymes of the body.
I love what you are doing. Keep up the good work. Love the proactive approach, don’t get sick.
Ten years ago after successful colon cancer surgery, I learned all I could on health and it continues to this day. It has served me well, especially through the pandemic. I was already taking all the nutrients shown to fight this virus that are antiviral in nature. As an older adult, unfortunately I also developed COPD and Psoriatic arthritis after the surgery. I was like my body was falling apart with these 3 things happening in short order. Prior to that I thought I was a fairly healthy 55 yr old. I was on the basketball court 3 days before my cancer surgery without a clue I had a tumor the size of a baseball inside my colon. I bring up this short history, because even though I breezed through two maybe three COVID infections, I wonder If the spike protein might be lingering or embedded in my DNA. See with my comorbidities, it’s impossible to tell if I am suffering from lingering effects, or is it just the natural progression of my progressive diseases. So far, I take no meds (except LDN) for my comorbidities, only nutrients an older person lacks and those helpful for my conditions. I alredy take NAC and digestive enzymes. I looked at nattokinase before, but never tried it.
I will give it a try. Must be good if it comes from natto (highest concentration of Mk-7) K2 has also found to be helpful against this virus, and everyone is short of this nutrient, as they are with D3.
I’m not looking for advice. Just wanted to applaud you on your approach to wellness. Rare when a medical doctor even knows anything about nutrients. Your post are very well written and very informative. I especially like the recap of the Dr. Arne Burkhardt findings. You explained it better than anyone who has written about it.
Kevin
Thanks for the kind words, Kevin. If there is a bright side to the pandemic, it made me more aware of nutraceuticals that I didn’t pay much attention to before. I dream that someday, health will come to many people, and prescription medicines will only be a last resort. I wish you the best of health.
Thanks. I’m not against medicine, but I think we all need to think critically about our health and make informed decisions. I have had great success with supplemental nutrients. Who knew a nagging lifelong problem (back pain/spasms) was a nutrient deficiency (Mg). My neurologist surely didn’t. My back hasn’t gone out in ten years now. That’s how I came across the benefits of supplements. And the older we get, the more we lack. No matter how many times we go to the gym and eat a healthy whole food diet. Of course, with my comorbidities I don’t go to the gym. I’m just saying doing the right thing, will likely not be enough. You will still lack the nutrients vital for good health and immune function. Hence young people and athletes dropping like flies becoming a daily occurrence. Just prior to COVID and the vaccines, the flu was killing young healthy people, even gym rats in 3 days time.
Is NAC and Bromelain safe to take if nursing!?
Thanks for the awesome info.
Hi Chantal, According to the NIH, Little is known about whether using bromelain during pregnancy or while breastfeeding is safe. One person in a forum said she used it to make her cervix soft for an easier delivery. https://forums.thebump.com/discussion/6529429/bromelain-supplements. Bergen country Acupuncture and wellness says, “Pineapples contain bromelain, the enzyme that reduces inflammation and swelling and boosts your immune system. Some medical professionals also believe that this enzyme can aid in fertility. https://bergencountyacupuncture.com/bromelain-and-fertility/. The FDA and NIH will not say that ANY drug is safe for pregnancy because no large scales studies have been done on pregnant women. When I searched for NAC and pregnancy, the results showed that it is OK for pregnancy. drug.com says, Animal studies did not show teratogenicity; slightly decreased fertility was seen at doses above the maximum human dose. Limited case reports did not report any adverse fetal or neonatal outcomes. This drug crossed the placenta and was measurable in the infant’s serum. A 1999 report concluded that pregnant women should be managed the same way as nonpregnant patients for acetaminophen overdose and that acetylcysteine therapy was protective to both mother and fetus. There are no controlled data on human pregnancy. https://www.drugs.com/pregnancy/acetylcysteine.html#pregnancy-warnings. Always ask your OB if taking the NAC and Bromelain is OK. They may have been asked that question many times before, and I would consider them to be more authoritative. Regards.
I also made small researches on my side on some lactation site for example (e-lactation.com) that concludes if certain herbs are safe while nursing or not…I have decided to try it since it’s mainly on the safe side but will open the capsules and take a smaller dose together and not everyday! Unfortunately I had to have a blood transfusion after birth and worried about those spike proteins still being in my body so I would like to clean up a little in case! I’ve already put my brother on it and by the second day said he is spitting up a lot of mucus! Thank you 🙂
Hi Chantal! Some people can have their own blood stored in the blood bank and get transfused with that stored blood once needed. Pregnant mothers usually make a lot of blood. Ask your doctors if that is possible. Another way is blood from the Unvaccinated Blood Bank (Safe Blood). Here is their website. https://safeblood.net/en/ Good luck to you and your baby!
Not in Canada unfortunately…I had lost so much blood and clots (for a 9 hour period) that I would have probably died since I was losing my consciousness and was yellow. It was red blood cells giving to me not whole blood so hopefully the timing and storage factor all went in my favor. Almost 9 months in. Praying and staying healthy, always!
I will pray for you too.