This article delves into the findings of a study that conducted a series of autopsies, revealing what happened to the organs of vaccinated individuals who died from breakthrough cases of COVID-19.
Sometimes, the dead speak to you. – Kenneth Eade
Introduction
High viral loads: What drives fatal cases of COVID-19 in vaccinees? An autopsy study is a paper published in Modern Pathology. It describes a series of autopsy cases among 29 fatal COVID-19 breakthrough infections.
Pathologists and other faculty members from the University of Augsburg in Germany did the research.
Sixteen partially and 13 fully vaccinated deceased individuals were included. They received the mRNA shots, Pfizer, Moderna, and viral-vector AstraZeneca vaccines.
Breakthrough infections occurred in the majority of individuals, and only two
were defined as “vaccination failure.”
Vaccination failure occurs when antibodies are not produced in response to vaccines. This can be due to immune suppression, such as the intake of steroids for specific medical conditions.
141 autopsy cases of unvaccinated people were compared as a control group and for comparison. Nineteen of those cases had previously been published.
Several concerning findings among the breakthrough cases are different from unvaccinated deaths.
Autopsy Findings
High viral loads were detected in the nasopharyngeal swabs and lung samples. The large amounts of SARS-CoV-2 viruses mean that viral replication was unchecked, allowing the viruses to spread and infect all body organs.
Cycle thresholds (CT) are used to determine viral loads. The lower the CT, the higher the viral loads. A CT of 28 is enough to test positive for COVID-19. This study’s average CT was 18, suggesting very high viral loads.
Partially vaccinated deceased individuals have higher viral loads than fully vaccinated, reflecting the depressed immune system after vaccination.
Antibody-dependent enhancement was proposed for the observed higher viral loads.
Antibody-dependent enhancement (ADE) occurs when antibodies, instead of neutralizing a virus, enhance its ability to infect cells and worsen the disease.
This phenomenon can lead to higher viral loads and more severe illness, particularly in the presence of suboptimal or non-neutralizing antibodies.
Viral dissemination in breakthroughs
Vaccinated
SARS-CoV-2 viruses were detected all over the body, especially in partially vaccinated compared to fully vaccinated cases. They were seen in various body organs, including the brain and cerebrospinal fluid.
Unvaccinated
In comparison, disseminations were previously found in only three of 19 deceased patients who were not vaccinated. Among the unvaccinated, the viruses were isolated only in the lungs. [2]
The viral spread was seen in five of the thirteen fully vaccinated.
Bacterial and Fungal Superinfections
A superinfection is a second infection that occurs after the first. A typical example is bacterial pneumonia on top of viral pneumonia. The most common reason for superinfection is the decrease in the immune system’s effectiveness due to viral infection.
11 out of 29 had superinfections. Four are aspergillosis cases. Aspergillus is a common fungus present in the body. Aspergillosis is an opportunistic infection that uses decreased immunity to grow and cause disease.
One patient died of an abscess in the kidneys. Superinfections are more common in breakthrough cases compared to those without vaccination.
The three mechanisms—vaccine-induced COVID symptoms, inadequate immune response, and antibody-dependent enhancement (ADE)—do not affect everyone who receives the vaccine.
Further research is needed to identify individuals at risk for complications from COVID-19 vaccination.
For now, consider what you just read before getting a booster shot. Early treatment of COVID-19 is essential to prevent ADE.
The explanation for the bodywide spread of the SARS-CoV-2 is explained in Disseminated SARS-CoV-2 autopsy findings in breakthrough cases explained
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Related:
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References:
- Hirschbühl, Klaus et al. High viral loads: what drives fatal cases of COVID-19 in vaccinees? – an autopsy study. Modern Pathology, Volume 35, Issue 8, 1013 – 1021
- Hirschbuehl et al. High viral loads: what drives fatal cases of COVID-19 in vaccinees? An autopsy study. medRxiv 2021.12.03.21267155; doi: https://doi.org/10.1101/2021.12.03.21267155
- Hirschbühl et al. Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach. PLoS One. 2021 Jul 19;16(7):e0254872. doi: 10.1371/journal.pone.0254872. PMID: 34280238; PMCID: PMC8289110.
- Lei et al. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Originally published31 Mar 2021 https://doi.org/10.1161/CIRCRESAHA.121.318902. Circulation Research. 2021;128:1323–1326
- Jiang H, Mei YF. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021;13(10):2056. Published 2021 Oct 13. doi:10.3390/v13102056
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