This article is about the proteins of the SARS-CoV-2 that enhance vascular permeability.
Blood vessels contain red and white blood cells, fluids, electrolytes, nutrients. Typically, there is tight control of fluid exchange inside and outside the blood vessels. In some diseases like COVID-19, there is increased vascular permeability.
The unregulated leak of fluids from the bloodstream leads to edema and disruption of normal processes. For example, toxins from the blood vessels can cause exotocicity or escape toxins to the brain.
The inner lining or the endothelium of the blood vessels needs to be very smooth. The smooth lining prevents blood clot formations that can obstruct blood flow.
COVID-19 causes a vascular leak, blood clots, and dysregulated immune system. The vascular leak in the lungs leads to edema formation and affects lung functions. Blood clots block blood supply and deprive organs of oxygen and nutrients leading to heart attacks and strokes. A defective immune system causes a hyperimmune response where the immune system attacks the human body and causes damage.
The SARS-C0V-2 virus is the cause of COVID-19. COVID-19 infection is divided into two phases. The first is when the virus replicates and begins to cause symptoms. The second part is more severe. That is when the number of SARS-C0V-2 virus dies down, and the host’s immune response against COVID-19 is the one that causes the damage.
If there is early treatment or the immune response is adequate, COVID-19 is aborted in the first part. If there are other medical problems like obesity, hypertension, and diabetes, the disease becomes worse. That is why early treatment is essential for everyone.
A study from the Tel Aviv University in Israel identified the proteins in the SARS-CoV-2 virus that can damage the blood vessels. The researchers cloned 26 of the 29 proteins of the SARS-CoV-2. Then they tested each protein on blood vessels.
The research showed 18 out of the 26 proteins (70%) increased vascular permeability. However, some nonstructural proteins or nsps like the nsp2, nsp5_c145a, and nsp7 cause more damage to the blood vessels. They also increased the formation of a coagulation factor called von Willebrand.
The von Willebrand factor is necessary for blood clot formation. If there is too much von Willebrand factor, then unhealthy blood clot formation happens.
The nsp2, nsp5_c145a, and nsp7 also promote cytokine release. Cytokines are signaling molecules that the body uses to coordinate the immune response. If there are too many cytokines, then a cytokine storm happens.
Another study shows that the spike proteins in COVID-19 disease and vaccines cause vascular damage. That study was featured in this article, The Spike Protein of the SARS-CoV-2 Can Cause Vascular Damage.
The image below shows the genes of the SARS-CoV-2. Note that the non-structural proteins are not part of the spike protein. That is why they are not present on the current mRNA (Pfizer and Moderna) and spike protein (AstraZeneca and Johnson & Johnson) vaccines.
My take on the study from the vaccine standpoint
The current vaccines from Pfizer, Moderna, AstraZeneca, and Johnson and Johnson only have the spike protein sequence of the SARS-CoV-2. They only induce anti-spike protein antibodies.
People who recovered from COVID-19 have antibodies to the spike proteins and the other SARS-CoV-2 proteins, including antibodies against nsp2, nsp5_c145a, and nsp7. Their antibody repertoire against SARS-CoV-2 is more robust and longer-lasting against future coronavirus infections.
This research explains why there are still COVID-19 deaths among the vaccinated. The table below is from the United Kingdom Health Security Agency COVID-19 vaccine surveillance report Week 45. (Week 45 is around November 8).
You can see on the left columns that the number of COVID-19 cases in the UK among the vaccinated > 30 years old is higher than the unvaccinated.
The report is limited to people presenting to emergency rooms and who died that week of reporting. The table does not include people in the hospital longer than that week and those directly admitted to the hospital who bypassed the emergency rooms.
Below is from the same report. It shows the higher death rates among the vaccinated who are >40 and above than the unvaccinated.
Why are there more deaths among the vaccinated? The lack of immune response to the nonstructural proteins that attack the blood vessels is one explanation.
Could it also be from antibody-dependent enhancement? Read about ADE here: What is Antibody-Dependent Enhancement, and why should you care.
The higher deaths could also be from the destructive effects of the vaccines on the adaptive immune response. That was discussed here, Study: SARS-CoV-2 Spike Proteins Impaired DNA Repair That Can Lead to Defective Immunity and Cancers and here Research Shows Decreased Antibody Response to Breakthrough Infections
Take-away message
Anyone both vaccinated and unvaccinated can still get COVID-19. Early treatment is essential to avoid being a death statistic.
You may be interested in the following:
- Update to FLCCC Treatment Protocol for the Delta Variant
- Update to the I-MASK+ Prevention & Early Outpatient Treatment Protocol for COVID-19
- What should the household do if someone has an Early COVID-19?
- The I-MASK+ for the Prophylaxis and Early Treatment Protocol of COVID-19
- The MATH+ Protocol Results in Greater Survival in Hospitalized COVID-19 Patients
- The I-RECOVER Management Protocol for Long Haul COVID-19 Syndrome
- What makes Ivermectin a kick-ass antiviral?
- The anti-COVID-19 properties of Quercetin
- Melatonin’s Multiple Actions Against COVID-19
- Povidone Iodine Works Great for the Prevention and Early Treatment of COVID-19!
- Vitamin C and COVID-19
- Zinc Deficiency Impairs the Immune System
- Adequate Vitamin D Prevents Severe COVID-19
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Reference:
Rauti et al. Effect of SARS-CoV-2 proteins on vascular permeability. eLife 2021;10:e69314 DOI: 10.7554/eLife.69314
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