Gout and Metabolic Syndrome




This article is a segment of a multi-part series about the multiple medical conditions associated with metabolic syndrome. For an introduction about the Metabolic Syndrome (MetS), see Part 1. Part 2 discusses MetS and its association with some pulmonary disease conditions. This section talks about MetS and its relationship with gout, obstructive sleep apnea, and common eye problems like glaucoma, retinopathy, Dand cataracts.

Gout is a painful condition characterized by pain in the ankles, big toe, or the knees. It is known as a disease of excess uric acid. This study from the journal, Current Hypertension Reports, Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal? Discusses the potential for the roles of uric acid in MetS and cardiovascular disease. Another excellent article, Uric acid in metabolic syndrome: From an innocent bystander to a central player  from the European Journal of Internal Medicine describes how a diet high in fructose leads to elevated uric acid levels. Hyperuricemia (elevated uric acid levels), often predicts hypertension, fat storage, diabetes, obesity, and fatty liver. The large intraabdominal (visceral) fat present in MetS produces inflammatory substances that spread all over the body. Is it any wonder why the medications used for gouts like colchicine, allopurinol, steroids, and Ibuprofen are all anti-inflammatories?Nihms773888F2.Jpg

 Eur J Intern Med. 2016 Apr; 29: 3–8.

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Sleep Apnea: Credits to Habib M’henni / Wikimedia Commons

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