This article discusses how ivermectin can prevent the binding of the spike protein to the blood vessel wall and potentially stop abnormal blood clots.
The article, Four ways the spike protein rapidly forms blood clots resistant to break down talked about how the spike protein of the SARS-CoV-2 virus can rapidly produce thick blood clots in people with COVID-19 and those who received the COVID-19 “vaccines.”
The SARS-CoV-2 spike protein attaches to the blood vessel walls using the ACE2 receptors present on the cell surfaces. After that, an inflammo-thrombotic response happens to lead to disease-causing blood clots.
Several studies showed that ivermectin could prevent blood clots by neutralizing the spike proteins.
Four studies show ivermectin blocks spike protein
- Lehrer and Rheinstein 2020 demonstrated that ivermectin binds to human ACE2 receptors using computerized models. ACE2 receptors differ among different species, which is why this study is significant. In their conclusion,
The ivermectin docking site we identified, between the viral spike and the ACE2 receptor, may interfere with the attachment of the spike to the human cell membrane.
2. Choudhury and colleagues 2021 also showed strong binding between ivermectin and Subunit 1 (S1) and Subunit 2 (S2) of the spike protein. They also found that ivermectin binds to the ACE2 receptors and helps modulate blood pressure and TMPRSS2, another enzyme that facilitates viral entry into the cells. Taken together, they wrap up their research,
Our data on the interaction between ivermectin and viral proteins indicated that ivermectin majorly acts by interfering with the viral entry through inhibiting the function of spike protein and protease.
These studies also indicate that ivermectin may also target human ACE2 and TMPRSS2 for exerting its inhibitory action over SARS-CoV-2.
3. Saha and Raihan 2021 used three different computer modeling techniques to show that ivermectin binds better with the spike protein’s active site than levosalbutamol (a drug for asthma). Below is their image of the ivermectin binding with the spike protein.
4. Eweas et al. 2021, in agreement with the previous studies, showed that ivermectin efficiently binds to the viral S protein and the human cell surface receptors ACE-2 and TMPRSS2. Thus, it can prevent the entry of the virus into the host cell.
Their other findings show that ivermectin binds to other SARS-CoV-2 viral proteins, suggesting that it might play a role in preventing viral replication.
Summary
To summarize, the four studies above using computer programs repeatedly showed the ability of ivermectin to bind the spike protein and prevent it from attaching to the ACE2 receptor and avert blood clots.
Ivermectin is used for Post Vaccine Syndrome
That and ivermectin’s anti-inflammatory properties are why the Front Line COVID-19 Critical Care Alliance (FLCCC) includes ivermectin in its treatment for Post COVID Vaccine Syndrome.
I reviewed that at The I-RECOVER Post-Vaccine Treatment Protocol.
A valid question is, are there any studies that showed the effectiveness of ivermectin for the treatment of COVID-19?
Yes. Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines is one of the most-read articles about ivermectin. It has many detractors, but the authors have convincingly defended their meta-analysis.
There are other researches about ivermectin efficacy. I discussed those at:
- City-wide use of ivermectin lowered COVID-19 cases, hospitalizations, and deaths in Itajaí, Brazil
- What makes ivermectin a kick-ass antiviral?
- Bayes Theorem Confirms Meta-analysis of Ivermectin’s Effectivity against COVID-19
- News that ivermectin overdose is clogging up hospitals is not true
- Ivermectin vs Remdesivir for COVID-19
- Solved! The Ivermectin African Enigma
- IVMMETA.COM: A website of studies on ivermectin’s efficacy
- Japanese company announces ivermectin has antiviral properties
- The many problems of the Ivermectin study in the NEJM
Take away message
Ivermectin can effectively bind spike proteins to prevent COVID-19 and the inflammo-thrombotic reaction post-COVID injections.
Truth heals. Lies kill. Don’t Get Sick!
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References:
- Lehrer S, Rheinstein PH. Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2. In Vivo. 2020 Sep-Oct;34(5):3023-3026. doi: 10.21873/invivo.12134. PMID: 32871846; PMCID: PMC7652439.
- Choudhury A, Das NC, Patra R, et al. Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach. Future Virol. 2021;10.2217/fvl-2020-0342. doi:10.2217/fvl-2020-0342
- Saha JK, Raihan MJ. The binding mechanism of ivermectin and levosalbutamol with spike protein of SARS-CoV-2. Struct Chem. 2021 Apr 12:1-8. doi: 10.1007/s11224-021-01776-0. Epub ahead of print. PMID: 33867777; PMCID: PMC8039806.
- Eweas et al. Molecular Docking Reveal Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2. Front. Microbiol., 25 January 2021 | https://doi.org/10.3389/fmicb.2020.592908
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