Repeated COVID booster shots Impair Immunity

This article discusses a study that showed that repeated injections of the recombinant COVID-19 “vaccines” lower the overall immune response.

The study, Extended SARS-CoV-2 RBD booster vaccination, induces humoral and cellular immune tolerance in mice, was published in iScience in December 2022.

Repeated Boosters Reduced Innate Immune Response

The study shows repeated COVID shots (fourth dose) using recombinant receptor binding (RBD) boosters degrade innate or humoral immunity by decreasing neutralizing antibodies against the Delta and Omicron variants.

Repeated boosters suppress the germinal centers in the lymph nodes where the B cells that produce the antibodies reside. The result is that the future production of specific antibodies for SARS-CoV-2 is lost.

Specifically, extended vaccination not only fully impaired the amount and the neutralizing efficacy of serum RBD-specific antibodies, but also shortened the long-term humoral memory.

More so, repeated COVID shots led to immune tolerance and allowed the SARS-CoV-2 to proliferate. That should never happen in an immune response.

This suggests that repetitive administration of RBD booster vaccines may actively promote humoral immune tolerance, instead of functional humoral immunity.

In their discussion, the authors said that their results confirmed the findings of Pérez-Then et al., who showed that a booster shot of Pfizer BNT162b2 in those who had two doses of Coronavac led to a 7.1-fold and 3.6-fold reduction of antibodies against the Omicron compared with the ancestral strain and the Delta variant, respectively.[3]

Repeated Boosters Degrade the Adaptive Immune System

The adaptive immune system was also corrupted. CD4+ and CD8+T cell activation was weakened.

CD4+ T lymphocytes or T helper cells direct other parts of the immune system to act against bacteria, viruses, and fungi.

CD8+ T cells, or killer T-cells, a white blood cell type, kill cancer cells, cells infected by viruses or bacteria, or any damaged cells. If not removed, cancer cells will increase. The presence of damaged and infected cells promotes chronic inflammation.

Memory Killer T cells are needed against newly-emerging SARS-CoV-2 variants.

Inactivation of the T helper and killer T cells impairs the adaptive immune system and prevents the body from fighting germs and cancer.

PD-1 and LAG-3 expressions also increase in the T helper and Killer T cells.

Programmed cell death protein 1 (PD-1) is a T and B cell surface protein that regulates the immune system. They down-regulate the immune system and promote self-tolerance by suppressing the inflammatory activity of T cells. This prevents autoimmune diseases, but the downside is that it hampers the immune system from killing cancer cells.

Lymphocyte-activation gene 3 (LAG-3) restricts immune responses against self-tissues and tumor cells. They prevent the destruction of tissues due to excessive and/or inappropriate immune responses.

In short, increasing PD-1 and LAG-3 is another way the COVID booster jabs decrease the immune response against viruses, bacteria, and cancer cells.

The other effects mentioned by the authors are the loss of immune memory and immune suppression.

Typically, the adaptive immune system builds a specific response against a new virus or variant so that a faster immune response will develop on subsequent exposures. This study shows that repeated mRNA shots make the immune memory goes away.

The authors aptly concluded.

Therefore, over-stimulation with the same booster vaccine or reinfection after vaccination may severely hamper the cellular immune response established by conventional vaccine course, which, together with challenged humoral immune responses, may lead to prolonged disease duration and/or aggravation of symptoms in recipients.

Comment

The Omicron variant is less deadly than ancestral and Delta variants. However, the booster shots impaired the overall immunity and potentially made an Omicron infection more severe.

Another way the COVID shots increase the susceptibility to future infections is by class switching on the Immunoglobulin G1 to a non or anti-inflammatory IgG4 discovered in another study.

This study can also explain why cancer cells are on the rise. Two pathologists who saw aggressive, multifocal, and concurrent cancers at a recent conference in Sweden raised this concerning issue.

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References:

Gao FX, Wu RX, Shen MY, Huang JJ, Li TT, Hu C, Luo FY, Song SY, Mu S, Hao YN, Han XJ, Wang YM, Li L, Li SL, Chen Q, Wang W, Jin AS. Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice. iScience. 2022 Dec 22;25(12):105479. doi: 10.1016/j.isci.2022.105479. Epub 2022 Nov 2. PMID: 36338436; PMCID: PMC9625849.
Maruhashi T, Sugiura D, Okazaki IM, Okazaki T. LAG-3: from molecular functions to clinical applications. J Immunother Cancer. 2020 Sep;8(2):e001014. doi: 10.1136/jitc-2020-001014. PMID: 32929051; PMCID: PMC7488795.
Pérez-Then E, Lucas C, Monteiro VS, Miric M, Brache V, Cochon L, Vogels CBF, Malik AA, De la Cruz E, Jorge A, De Los Santos M, Leon P, Breban MI, Billig K, Yildirim I, Pearson C, Downing R, Gagnon E, Muyombwe A, Razeq J, Campbell M, Ko AI, Omer SB, Grubaugh ND, Vermund SH, Iwasaki A. Neutralizing antibodies against the SARS-CoV-2 Delta and Omicron variants following heterologous CoronaVac plus BNT162b2 booster vaccination. Nat Med. 2022 Mar;28(3):481-485. doi: 10.1038/s41591-022-01705-6. Epub 2022 Jan 20. PMID: 35051990; PMCID: PMC8938264.

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