This article features a study of patients admitted to the intensive care units due to dangerously high blood sugars after receipt of the COVID “vaccines.”
The study was peer-reviewed and published in the Journal of the Endocrine Society. The authors are from the Albert Einstein College of Medicine in New York.
In the case series, two patients were known to have Type 2 or adult-onset diabetes. One is not but will later be diagnosed with diabetes.[1]
For a start, let us have a bit of background.
Diabetes
Diabetes is a condition where blood sugar is high. Prolonged, elevated blood sugars are unhealthy because it eventually causes blood vessel and organ damage.
People without diabetes have a fasting blood sugar of less than 100. Acceptable blood sugars if someone has diabetes should be less than 180 after meals.
Diabetes is a risk factor for heart attacks, strokes, limb amputation, and kidney failure. People with diabetes are prone to have bad COVID-19 outcomes, so they are advised to have COVID injections.
Diabetes, DKA, and HHS
Acute complications can happen in diabetes. Very high blood sugar can lead to DKA and HHS.
Diabetic ketoacidosis (DKA) combines elevated blood sugar and an acidic environment in the blood. DKA comes from a lack of insulin.
Insulin is a hormone that drives glucose or sugar into the cells to provide energy. If the cells do not have glucose, they will turn to fat for fuel.
However, ketones, a by-product of fat metabolism, lead to an acidic environment in the blood and the whole body. Normally, the body’s pH is neutral, which is the optimal condition for cellular functions.
Note: Do not confuse ketosis in DKA with ketosis in a ketogenic diet. That is different.
In the acidic milieu of DKA, the organ systems begin to shut down. A typical patient will present dehydrated, confused, vomiting, breathing fast, complaining of abdominal pain, and having unstable vital signs.
If untreated, they become comatose and die.
Hyperosmolar Hyperglycemic Syndrome (HHS) is similar to DKA in that the blood sugar is soaring but different in that the acetone or ketone levels are not high. Thus their blood is not acidic.
HHS presents like DKA but has a 20% mortality rate, ten times higher than DKA.
DKA and HHS need aggressive intravenous fluids, insulin infusions, and close monitoring in an intensive care unit.[2]
HHS and DKA after the COVID jabs
The case series reported two patients who developed HHS and one who had both HHS and DKA within 48 hours of COVID-19 vaccination.[1]
All had hyperglycemic emergencies after the first dose of the Pfizer or Moderna CV19 injections.
The table below puts together their clinical presentations.
All three tested negative for SARS-CoV-2. COVID-19 must be ruled out since it can cause the same diabetes emergencies.
All of them were treated with insulin infusion. They all improved and were discharged on subcutaneous insulin therapy.
At home, their blood sugar levels remained controlled, and insulin was discontinued in all three within eight weeks. They remain well-controlled on oral DM medications.
Why caused the complications?
A new preprint study showed that antibodies against insulin receptors could be found in some elderly patients with severe COVID-19.[3]
An insulin receptor is where the insulin attaches to allow the sugar in the blood to get into the cells.
Anti-insulin receptor antibodies block insulin from attaching to their receptors and prevent sugar from entering the cells. The result is high blood sugar. I discussed that paper in Diseases From SARS-CoV-2 Autoantibodies.
Autoantibodies can form due to molecular mimicry where a segment of the protein sequence in a foreign antigen like the SARS-CoV-2 is similar to a human protein like an insulin receptor.
DKA and HHS can also happen with COVID-19. Chan and colleagues reported six patients with combined DKA/HHS caused by COVID-19, a SARS-CoV-2 infection. They are in their 50s, all males, three Hispanic, and three African American. [4]
HHS and DKA in VAERS
The Vaccine Adverse Event Reporting System (VAERS) is where anyone can report a vaccine adverse event.
When I searched the VAERS data last night, there were 471 hyperglycemia, 12 HHS, 276 DKA, and three Diabetic Hyperosmolar Comas.
The cases in the VAERS are underreported by a factor of 100 based on the Lazarus report.
Adverse events from drugs and vaccines are common, but underreported.
Although 25% of ambulatory patients experience an adverse drug event, less than 0.3% of all adverse drug events and 1-13% of serious events are reported to the Food and Drug Administration (FDA).
Likewise, fewer than 1% of vaccine adverse events are reported.
Thus, for any number you see below, add two zeroes.
Hyperglycemia – 471
Diabetes can happen after a COVID jab. One patient in the study of Lee et al., a 52-year-old female, did not have diabetes until she had her Pfizer shot.[1]
COVID-19, HHS, and DKA
A study from Hong Kong by Wan et al. evaluated Type 2 Diabetes patients who received the Pfizer BNT162b2 and CoronaVac vaccines.[9]
Of 141,224 who had the Pfizer shot, 301 (0.2%) developed DKA, and 1,900 (1.3%) had HHS.
Among the 209,739 Coronavac recipients, 297 (0.1%) had DKA, and 2,699 (1.3%) were complicated by HHS.
So, if we delve into semantics, are the complications very rare, rare, uncommon, or common?
I-base, a website for HIV treatment, has a table for words relating to the frequency of side effects based on the European Medicines Agency. The EMA is the European equivalent of the US Food and Drug Administration.
Source: I-baseBased on the EMA chart, we can say that the HHK and DKA after COVID-19 injections in people with diabetes range from uncommon to common.
Take Away Message
COVID-19 and its injections can precipitate severe and potentially fatal diabetic complications. People with diabetes should monitor their blood sugar using a home glucometer like the Metene TD-4116 Blood Glucose Monitor Kit if they are sick or after the COVID-19 injections.
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Related:
- COVID-19, Autoimmunity and Vaccination, Part 1
- COVID-19, Autoimmunity, and Vaccination Part 2
- COVID-19, Autoimmunity, and Vaccination Part 3
- Molecular Mimicry between the SARS-CoV-2 and the Breathing Center
- Molecular mimicry between the spike protein and humans can shut down platelet production
- Autoimmune antibodies and diseases after COVID-19 disease and injections
- The SARS-CoV-2 spike protein cross-reacts with eleven human proteins to cause autoimmune diseases
- Adverse Events of Special Interest (video)
- The Monkeypox Vaccines Adverse Events of Special Interest
References:
- Lee HJ, Sajan A, Tomer Y. Hyperglycemic Emergencies Associated With COVID-19 Vaccination: A Case Series and Discussion. J Endocr Soc. 2021 Sep 25;5(11):bvab141. doi: 10.1210/jendso/bvab141. PMID: 34604689; PMCID: PMC8477915.
- Adeyinka A, Kondamudi NP. Hyperosmolar Hyperglycemic Syndrome. 2022 Dec 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 29489232.
- Fonseca D et al. SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner. medRxiv
- Chan KH, Thimmareddygari D, Ramahi A, Atallah L, Baranetsky NG, Slim J. Clinical characteristics and outcome in patients with combined diabetic ketoacidosis and hyperosmolar hyperglycemic state associated with COVID-19: A retrospective, hospital-based observational case series. Diabetes Res Clin Pract. 2020 Aug;166:108279. doi: 10.1016/j.diabres.2020.108279. Epub 2020 Jun 25. PMID: 32592843; PMCID: PMC7314685.
- United States Department of Health and Human Services (DHHS), Public Health Service (PHS), Centers for Disease Control (CDC) / Food and Drug Administration (FDA), Vaccine Adverse Event Reporting System (VAERS) 1990 – 12/02/2022, CDC WONDER On-line Database. Accessed at http://wonder.cdc.gov/vaers.html on Dec 13, 2022, 7:00:59 PM
- United States Department of Health and Human Services (DHHS), Public Health Service (PHS), Centers for Disease Control (CDC) / Food and Drug Administration (FDA), Vaccine Adverse Event Reporting System (VAERS) 1990 – 12/02/2022, CDC WONDER On-line Database. Accessed at http://wonder.cdc.gov/vaers.html on Dec 13, 2022, 6:53:54 PM
- United States Department of Health and Human Services (DHHS), Public Health Service (PHS), Centers for Disease Control (CDC) / Food and Drug Administration (FDA), Vaccine Adverse Event Reporting System (VAERS) 1990 – 12/02/2022, CDC WONDER On-line Database. Accessed at http://wonder.cdc.gov/vaers.html on Dec 13, 2022, 6:56:07 PM
- United States Department of Health and Human Services (DHHS), Public Health Service (PHS), Centers for Disease Control (CDC) / Food and Drug Administration (FDA), Vaccine Adverse Event Reporting System (VAERS) 1990 – 12/02/2022, CDC WONDER On-line Database. Accessed at http://wonder.cdc.gov/vaers.html on Dec 13, 2022, 6:58:11 PM
- Wan EYF, Chui CSL, Mok AHY, Xu W, Yan VKC, Lai FTT, Li X, Wong CKH, Chan EWY, Lui DTW, Tan KCB, Hung IFN, Lam CLK, Leung GM, Wong ICK. mRNA (BNT162b2) and Inactivated (CoronaVac) COVID-19 Vaccination and Risk of Adverse Events and Acute Diabetic Complications in Patients with Type 2 Diabetes Mellitus: A Population-Based Study. Drug Saf. 2022 Dec;45(12):1477-1490. doi: 10.1007/s40264-022-01228-6. Epub 2022 Oct 2. PMID: 36184720; PMCID: PMC9527074.
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