Why do some people have severe adverse effects from the mRNA COVID shots and others do not? A study published in the Biophysical Journal explains.
The body quickly destroys injected messenger RNAs. Moderna and Pfizer enclosed the mRNA inside a lipid nanoparticle (LPN) to prevent that. LPN also allows the large mRNAs to enter the cells physically and start sike protein production.
The image below shows what a functional lipid nanoparticle with an mRNA look like under electron microscopy.
The mRNA shots have to be in a freezing environment. The Moderna and BioNTech/Pfizer must be kept between −15 and −25 °C and between −60 and −90 °C, respectively, or they will degrade.
A study by Moderna showed that physically stressed lipid nanoparticles that have undergone multiple freeze-thaw cycles could damage the lipid nanoparticle and the mRNA inside.
The image below shows aggregation (right), liberated mRNA (blue arrow), and the formation of liposomal structures containing mRNA (red arrow). The black arrow indicates an LNP that appears ready to burst.
Image b compares the concentration of stressed and physically stressed nanoparticles present. Note the low number of particles in the physically stressed group.
If someone got injected with a COVID shot that had gone in and out of the freezer several times and now has damaged mRNA, their immune system might have attacked the degraded mRNA before it entered their lymph nodes.
The result will be no vaccine effect. No immunity to SARS-CoV-2 developed, and fewer to no chances of an adverse effect. Did you get lucky?
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Reference:
Brader ML, Williams SJ, Banks JM, Hui WH, Zhou ZH, Jin L. Encapsulation state of messenger RNA inside lipid nanoparticles. Biophys J. 2021 Jul 20;120(14):2766-2770. doi: 10.1016/j.bpj.2021.03.012. Epub 2021 Mar 25. PMID: 33773963; PMCID: PMC8390897.
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