The I-RECOVER Post-Vaccine Treatment Protocol

Posted on by Jesse Santiano, M.D.

This article aims to introduce the I-RECOVER management for Post COVID-19 Vaccine Syndrome.

The FLCCC defines Post COVID vaccine syndrome as “a temporal correlation between a patient receiving a COVID-19 vaccine and the beginning or worsening of clinical manifestations is sufficient to diagnose a COVID-19 vaccine-induced injury when the symptoms are unexplained by other concurrent causes.”

These symptoms include brain fog, joint pains, blood clot formation, herpes reactivation, tinnitus, Bell’s palsy or facial weakness, neurologic problems, and allergic symptoms.

To address the issue of Post COVID vaccine syndrome, the Front Line COVID-19 Critical Care Alliance (FLCCC) issued the I-RECOVER management for Post (COVID-19) Vaccine Syndrome on May 25, 2022.

The treatment approach is based on the postulated disease mechanism, clinical observation, and patient anecdotes. Treatment is individualized according to each patient’s presenting symptoms and disease syndromes.

Since many health authorities like the NIH and the CDC do not recognize Post Vaccine Syndrome as an entity, there will likely not be any funding for any randomized controlled trials (RCT) for its treatment. However, the FLCCC doctors are doing what doctors have done historically.

If a new disease occurs, physicians talk among themselves to understand it and use what is known to be effective based on the disease mechanism. In short, doctors don’t have to wait for RCTs or bureaucratic “experts” from the CDC to tell them how to treat.

This protocol was a collaborative effort drawing on the expertise of a dozen world-renowned physicians that are affiliated with the FLCCC. Post Vaccine Syndrome may mimic other medical conditions that should be ruled out.

Baseline Testing

Before treatment, baseline laboratory work is recommended to rule out possibilities other than Post vaccine syndrome. Your medical provider may order these tests.

  1. CBC with differential and platelet count
  2. Standard blood chemistries, including liver function tests
  3. D-Dimer—as a marker of clotting activation
  4. C-reactive protein (CRP)—as a marker of ongoing inflammation (A comprehensive extensive cytokine/chemokine panel is unnecessary and very costly, and the results will not change the treatment approach.)
  5. Early morning cortisol—some patients develop autoimmune adrenal failure.
  6. Thyroid Stimulating Hormone (TSH)—to exclude thyroid disease
  7. HbA1C—Vaccine-injured patients are at an increased risk of developing diabetes.
  8. Troponin, pro-BNP, Galectin-3, and ST2—to exclude cardiac disease.
  9. CMV, EBV, Herpes simplex, HHV6, and mycoplasma serology/PCR—to exclude viral/bacterial reactivation (In patients who respond poorly to therapy, it may be helpful to check for Lyme (Bb), Bartonella, and Babesia tick-borne diseases—e.g., https://igenex.com/ and https://www.mdlab.com/)
  10. Vitamin D level (25OH Vitamin D)
  11. In patients with allergic features and those who experienced an acute reaction to the vaccine, the following tests may be helpful: Eosinophil count, IgE levels,  RAST testing, skin testing, Serum tryptase, serum histamine, and 24-h urine N-methylhistamine should be considered in Mast Cell Activation Syndrome (MCAS).
  12. Limited screening autoantibodies. Lupus anticoagulant (if positive, B2 microglobulin, etc.) and ANA. Vaccine-injured patients, particularly those with autonomic dysfunction/ Small fiber neuropathy (SFN), frequently have an extensive array of autoantibodies directed against G-protein coupled cell surface receptors, ACE-2, neurons, myelin, and other self-epitopes. The presence or absence of these antibodies has little impact on the management of these patients.
By William Rafti of the William Rafti Institute

First Line Therapies

The following are over-the-counter nutritional supplements. They are listed in the order of importance.

  1. Intermittent daily fasting
  2. Ivermectin; 0.2-0.3 mg/kg, daily for up to 4-6 weeks
  3. Low dose naltrexone (LDN)
  4. Melatonin; 2-6 mg slow release/extended-release before bedtime
  5. Aspirin; 81 mg/day
  6. Vitamin C; 1000 mg orally three to four times a day.
  7. Vitamin D and Vitamin K2; The dose of Vitamin D should be adjusted according to the baseline Vitamin D level. However, a 4000-5000 units/day of Vitamin D and Vitamin K2 100 mcg/day is a reasonable starting dose.
  8. Quercetin; 250-500 mg/day (or mixed flavonoids). Quercetin should be used with caution in patients with hypothyroidism, and TSH levels should be monitored.
  9. Nigella Sativa; 200-500 mg twice daily. [68-71] It should be noted that thymoquinone (the active ingredient of Nigella Sativa) decreases the absorption of cyclosporine and phenytoin.
  10. Probiotics/prebiotics; Patients with post-vaccine syndrome classically have a severe dysbiosis with loss of Bifidobacterium. Kefir is a highly recommended nutritional supplement high in probiotics. Suggested probiotics include Megasporebiotic (Microbiome Labs) and True Bifido Pro (US Enzymes).
  11. Magnesium 500 mg/day.
  12. Omega-3 fatty acids: Vascepa, Lovaza, or DHA/EPA; 4 g/day. Omega-3 fatty acids play an essential role in the resolution of inflammation by inducing resolvin production. Resolvin is involved in cellular restoration after injury.

Adjunctive/Second Line therapies

Some in this list, like HCQ, Prednisone, and Fluvoxamine, need a prescription. They are listed in order of importance.

  1. Hydroxychloroquine (HCQ); 200 mg twice daily for 1-2 weeks, then reduce 200 mg/day as tolerated.
  2. Intravenous Vitamin C; 25 g weekly, together with oral Vitamin C 1000 mg (1 gram) 2-3 times per day
  3. Fluvoxamine; Start on a low dose of 12.5 mg/day and increase slowly as tolerated
  4. “Mitochondrial energy optimizer” with pyrroloquinoline quinone (PQQ) (e.g., Life Extension Energy Optimizer or ATP 360®).
  5. N-acetyl cysteine (NAC); 600-1500 mg/day.
  6. Sulforaphane (broccoli extract); 400 mcg/day.
  7. Low dose corticosteroid; 10-15 mg/day prednisone for three weeks. Taper to 10 mg/day and then 5 mg/day, as tolerated. (prescription needed)
  8. Behavioral modification, mindfulness therapy, and psychological support may help improve patients’ overall well-being and mental health. Suicide is a real problem in vaccine-injured patients. Support groups and consultation with mental health professionals are essential.
  9. Tai Chi is a Chinese martial art that is also meditative. It is beneficial for Long COVID. 

The third line of therapy is Hyperbaric Oxygen Therapy (HBOT). HBOT uses an airtight chamber to increase the pressure of oxygen. HBOT has potent anti-inflammatory properties by decreasing pro-inflammatory cytokines. (HBOT) should be considered in cases of severe neurological injury and patients showing a rapid downhill course.

Another method that may be effective is the Wim Hof Method. A small study showed that WMF decreases inflammation.

Secrets of the Ice Man: Voluntary control of adrenaline and the effect on the immune system.

The Front Line COVID-19 Critical Care Alliance (FLCCC) has produced many prevention and treatment protocols for COVID-19 that I have used for my patients. This protocol for Post COVID Vaccine Syndrome is backed by experience and science. It is the first version. Therefore it may get updated as experience and more research accumulates.

Know more about intermittent fasting from the expert: The Complete Guide to Fasting.

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Source:

FLCCC I-RECOVER: Post-Vaccine Treatment

You may also like:

  1. Study: Intermittent fasting results in better COVID-19 outcomes
  2. Melatonin’s Multiple Actions Against COVID-19
  3. Nigella Sativa or Black Seed, Black Cumin for COVID-19
  4. The anti-COVID-19 properties of Quercetin
  5. Adequate Vitamin D Prevents Severe COVID-19
  6. Vitamin C and COVID-19
  7. Adequate Vitamin D Prevents Severe COVID-19
  8. Zinc Deficiency Impairs the Immune System
  9. Vitamin B1 or Thiamine in Infections
  10. What makes Ivermectin a kick-ass antiviral?
  11. Aspirin for the early treatment of COVID-19
  12. Nigella Sativa or Black Seed, Black Cumin for COVID-19

Image Credit: Syringe By William Rafti of the William Rafti Institute – Transferred from en. Wikipedia to Commons by PanaromicTiger., Attribution, https://commons.wikimedia.org/w/index.php?curid=6709116.

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