The relationship between muscles, excess fat, disease burden, and life span

29 621 participants

A higher cumulative morbidity burden in older adulthood was observed among those who
were overweight (7.22 morbidity-years) and those with classes I and II obesity (9.80) compared with
those with a normal BMI (6.10) in midlife (P < .001).

Mean age at death was similar between those
who were overweight (82.1 years [95% CI, 81.9-82.2 years]) and those who had normal BMI (82.3
year but shorter in those who with classes I and II obesity (80.8 years
[95% CI, 80.5-81.1 years]).

Cumulative median per-person
health care costs in older adulthood were significantly higher among overweight participants
($12 390 [95% CI, $10 427 to $14 354]) and those with classes I and II obesity ($23 396 [95% CI,
$18 474 to $28 319]) participants compared with those with a normal BMI (P < .001)

Reference:

Khan SS, Krefman AE, Zhao L, et al. Association of Body Mass Index in Midlife With Morbidity Burden in Older Adulthood and Longevity. JAMA Netw Open. 2022;5(3):e222318. doi:10.1001/jamanetworkopen.2022.2318

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