The proteins formed in the body have to be appropriately folded to be functional. If misfolded, they become prions, and they are not only defective but can also spread and accumulate to manifest as neurodegenerative diseases.
A Lewy body is one type of prion. They are found in Lewy body dementia, the second most common type of progressive dementia after Alzheimer’s.
Lewy bodies are also found in Parkinson’s disease. In Lewy dementia and Parkinson’s disease, the Lewy bodies accumulate in the brain regions involved in thinking, memory, and movement.
This article discusses the discovery of Lewy bodies in monkey brains after infection with SARS-CoV-2.
The study was done at the Biomedical Primate Research Centre in the Netherlands. It is a preprint and available at BioRxiv.
The study involved the introduction of the SARS-CoV-2 viruses in the nose and trachea of four macaques and four cynomolgus monkeys. Macaques and cynomolgus monkeys are rhesus monkeys and are acceptable substitute models for studying the effects of COVID-19 in humans.
Four uninfected monkeys served as control. All animals were euthanized after 5-6 weeks of infection.
Results
The brains of all eight infected animals showed signs of inflammation. More than that, Lewy bodies were detected by immunohistochemistry in their ventral midbrain.
The ventral midbrain region is next to the caudate nucleus, the same location where the Lewy in Parkinson’s disease and Lewy body dementia are found. No Lewy bodies were seen in the control monkeys.
Additional findings show inflamed T-cells in the brain, suggesting that the viruses used the T cells to cross the blood-brain barrier.
Another way the viruses enter the brain could be the infected nerves originating and going to the brain. One of which is the olfactory nerves coming from the nose. Evidence of infection is the absence of smell as one of the symptoms of COVID-19.
This study shows that COVID-19 infection can cause Lewy body dementia or Parkinson’s disease. But what about the COVID-19 “vaccines”? Can they also form Lewy bodies?
A review article by Oldfield and colleagues put together several pieces of research that showed that the spike protein could cross the blood-brain barrier and cause inflammation.
By this time, many people already had COVID-19, had been vaccinated, or both. Does that mean we will all have Parkinson’s or Lewy body dementia?
To answer this, it is essential to know that diseases happen from an interplay of several factors. Just because prions form does not always mean a neurodegenerative illness will occur.
Autophagy
In a person’s lifetime, prions form in the brain. However, the body recognizes those abnormal proteins and breaks them down thru the process of autophagy.
Autophagy is the body’s process of breaking down and recycling old, abnormal, and dysfunctional proteins. And that includes prions.
It is possible that the autophagy mechanism was not enough or flawed in neurodegenerative diseases like Parkinson’s and Alzheimer’s.
Exercise, intermittent fasting, and drinking coffee are the ways to promote autophagy.
- Exercise alone can induce autophagy.
- Intermittent fasting for Post COVID Vaccine Syndrome: Autophagy
- Autophagy – How to Recycle Yourself
- Intermittent fasting for Post COVID Vaccine Syndrome: Autophagy
Exercise and intermittent fasting can also decrease the risk of cardiovascular diseases.
Truth heals. Lies kill. Don’t Get Sick!
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References:
- SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques.
- Oldfield PR, Hibberd J, Bridle BW. How Does Severe Acute Respiratory Syndrome-Coronavirus-2 Affect the Brain and Its Implications for the Vaccines Currently in Use. Vaccines (Basel). 2021 Dec 21;10(1):1. doi: 10.3390/vaccines10010001. PMID: 35062662; PMCID: PMC8780773.
- López-Pérez Ó, Badiola JJ, Bolea R, Ferrer I, Llorens F, Martín-Burriel I. An Update on Autophagy in Prion Diseases. Front Bioeng Biotechnol. 2020 Aug 27;8:975. doi: 10.3389/fbioe.2020.00975. PMID: 32984276; PMCID: PMC7481332.
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