Pfizer Jab Alters Immune Response in Children and Adults

This article discusses new research showing that the Pfizer BNT162b2 COVID-19 jab changes the immune response and can potentially make someone more prone to viral, bacterial, and fungal infections.

Frontiers in Immunology published BNT162b2 COVID-19 vaccination in children alters cytokine responses to heterologous pathogens and Toll-like receptor agonists on August 25, 2023.[1]

The authors are from the Murdoch Children’s Research Institute, The Royal Children’s Hospital, and The University of Melbourne. All in Australia.

Off-Target Effect

A heterologous or off-target activity is a condition where vaccination or a previous infection alters the immune response to other disease-causing germs. It can enhance or lower the immune response.

Here are some examples cited by the authors.

A measles infection can increase deaths related to other infections.[2]
Smallpox vaccination reduces the risk of infectious disease hospitalization. [3]
Vaccination against tuberculosis (TB) with BCG reduced infection-related infant mortality rates in infants. [4]
A COVID-19 injection from AstraZeneca has been found to prolong innate immune activation and induce trained immunity among adults up to three months after the shot. [5] That means a prolonged state of inflammation.

In this study from Australia, they want to know if the Pfizer shot also has the same off-target activity against other pathogens or disease-causing microbes other than SARS-Cov-2, the virus that causes COVID-19.

Study Method

Blood samples from 29 children aged 5-11 years were studied to check their immune responses.

The samples were obtained before and 28 days after a second Pfizer shot (BNT162b2).

Samples from eight children were analyzed six months after the Pfizer “vaccination.”

Introducing infections to children is unethical and, of course, not allowed. That is why they tested the samples in the laboratory instead.

They used killed viruses and bacteria, SARS-CoV-2 antigens, to stimulate the immune response, and then they measured the cytokine levels.

Cytokines are proteins used by cells to interact with one another. In the presence of infection, expect a rise in inflammatory cytokines.

Results

If you have a child that had the Pfizer jab, have a sit first before reading the following.

SARS-CoV-2 mRNA shots decrease the inflammatory immune response against other viruses, bacteria, and fungal pathogens.

Our study showed that, in children, SARS-CoV-2 mRNA vaccination decreases inflammatory cytokine responses (IFN-γ, MCP-1, IL-6, IL-8 and IL-15) to heterologous bacterial, fungal and viral re-stimulation.[1]

Interferon-gamma (IFN-γ), Monocyte chemoattractant protein-1 (MCP-1, Interleukin-6 (IL-6), IL-8, and IL-15 are all needed to defend against bacterial, fungal, and viral infections.

A decrease in the mentioned cytokines means they are more prone to those infections!

Their findings align with another study, The Impact of BNT162b2 mRNA Vaccine on Adaptive and innate immune responses, done in adults that was just published this month by Clinical Immunology. [6]

The authors are from the Netherlands’ Radboud Institute for Molecular Life Sciences, the Department of Computational Biology for Individualised Infection Medicine in Helmholtz, Germany, and the Institute of Virology in Düsseldorf, Germany.

They found that the Pfizer shot decreased the innate immune response in sixteen adults. Participants were 26–59 years of age, seven men and nine women, and without known acute or chronic diseases.

Here are some quotes with added emphasis.

Our study showed either no change or downregulation in the type I IFN-related pathways, which might suggest that BNT162b2 vaccination induces innate immune memory that also consists of tolerance characteristics.

Tolerance means the immune system is tolerating or allowing infections to persist. This is similar to previous research showing that the Moderna and Pfizer mRNA shots increase IgG4 of the immune system, thereby enabling the SARS-CoV-2 to multiply rather than kill them.

Not all cytokines are pro-inflammatory. Others are anti-inflammatory. They help to balance the immune response to prevent a hyperactive immune system and autoimmune diseases.

This brings us to another piece of evidence from the group of Föhse et al. [6]. They showed that the lowered immune response is due to increased anti-inflammatory cytokine IL-1RA.

IL-1RA or interleukin-1 receptor antagonist protein. It inhibits the activity of other inflammatory cytokines.

Here is a quote I have to dig up from page 10 of their paper since the abstract, which did not mention the increase in IL-1RA, made no sense to me. (Emphasis added)

In this respect, the production of the cytokines from the IL1/IL-6 pathway, including the anti-inflammatory IL-1Ra, tended to increase six months after the first vaccination.

More remarkable is, however, the tendency of lower interferon responses after BNT162b2 vaccination.[6]

Again, interferons are needed to protect against infections. Lower interferon levels mean a weaker immune system. An example is a weaker response against COVID-19 and other viruses.

… we observed a downregulation of the type I interferon pathway in response to influenza at the transcriptional level, and lower IFN-α production by PBMCs (Periperal Blood Mononuclear Cells) after stimulation with SARS-CoV-2.[6]

That means that upon exposure to SARSCoV-2, the monocytes, a part of the immune system, produce less interferon to control the infection.

A similar pattern can be observed for IFN-γ, which was produced less by PBMCs after immunization when exposed to various viral stimuli.[6]

Returning to the featured study, their research showed higher cytokine production against SARS-CoV-2 antigens.

At the end of the report, the authors did not fully state that the mRNA shot can increase the risk of infection from other pathogens, but they voiced caution.

Our findings suggest SARS-CoV-2 mRNA vaccination could alter the immune response to other pathogens, which cause both vaccine-preventable and non-vaccine-preventable diseases.

This is particularly relevant in children as they: have extensive exposure to microbes at daycare, school, and social occasions; are often encountering these microbes for the first time; and receive multiple vaccines as part of routine childhood vaccination schedules.

There are currently no data on the clinical effects of COVID-19 vaccination-related heterologous effects in children.[1]

I suspect that the authors know that based on their findings, we can expect to see more infections in jabbed children, but they cannot put that in their paper, or else it won’t get published.

Proof of More Viral Infections in Children

The CDC Recommended Pediatric COVID-19 Vaccine for Children 5 to 11 Years on November 2, 2021, and Children Ages 6 Months through 5 Years on December 9, 2022.

What has happened since?

Invasive Group A Strep

October to December 2022 – From the CDC Mortality and Morbidity Weekly Report – Increase in Pediatric Invasive Group A Streptococcus Infections — Colorado and
Minnesota. Notable quote,

During fall 2022, a resurgence of invasive group A Streptococcus (iGAS) infection in children and adolescents was observed in two of CDC’s Emerging Infections Program (EIP)* surveillance sites: Colorado (Denver metropolitan area) and Minnesota (entire state).

This increase followed historic declines in invasive bacterial diseases during 2020, concurrent with mitigation strategies implemented during the COVID-19 pandemic

Respiratory Viruses

February 2023 from the journal Pediatrics, Codetections of Other Respiratory Viruses Among Children Hospitalized With COVID-19.

Among 4372 children hospitalized, 62% had non-SARS-CoV-2 respiratory virus testing, of which 21% had a codetection.

Among children <5 yo, having any viral codetection was significantly associated with severe illness.

Among children <2 yo, respiratory syncytial virus (RSV) codetections were also significantly associated with severe illness

NPR reports: A surge in sick children exposed a need for significant changes to U.S. hospitals. The article was written in response to increased RSV and other infectious diseases among children.

ECHOVIRUS 11

July 6, 2023 – NBC News: WHO reports dozens of babies sickened by deadly viral infections

Reports of at least three dozen cases of dangerous and often deadly viral sepsis in babies across Europe— along with increasing circulation of similar viruses that typically spike in the summer and early fall — have pediatric infectious diseases experts in the U.S. on edge.

On Friday, the WHO confirmed that at least 26 infants in Croatia, France, Italy, Spain, Sweden and the United Kingdom had been infected with a rare type of enterovirus, called echovirus-11.

Eight of those babies died, with most deaths reported in France following organ failure and sepsis.

That is more than would be expected, a WHO spokesperson wrote in an email. “It is considered unusual due to the extremely rapid deterioration and associated case fatality rate amongst the affected babies,” the spokesperson wrote.

While some of those 26 echovirus-11 cases were identified as early as 2022, at least half of the new cases were reportedsince late spring 2023.

Adenovirus Explains Rise in Hepatitis Cases

August 4, 2023 – Red Book Online Outbreaks: Hepatitis Cases Possibly Associated with Adenoviral Infection

As of August 2, 2023, 47 states and jurisdictions have reported 396 pediatric patients under investigation over the past 21 months, which is an increase of 287 from the 109 publicly reported on May 5, 2022.

Of the previously reported 109 cases in the US:

The majority of cases were in young children, with a median age of 2 years

More than half had a confirmed adenovirus infection, most commonly F type 41

Ninety percent were hospitalized

Fourteen percent required liver transplants

While the majority fully recovered, five have died

CDC continues to investigate the cause and any contributing factors (eg immune response to adenovirus, coinfections, environmental exposures, medications) related to these acute cases of hepatitis in young children

Maybe they should ask if the kids were COVID jabbed!

COVID-19

September 1, 2023 – CNN – It seems like everyone has Covid-19. Here’s why this wave is probably worse than official data suggests.

“There is more transmission out there than what the surveillance data indicates,” said Janet Hamilton, executive director of the Council of State and Territorial Epidemiologists. “And we should be paying attention to it, because we are starting to see an increase.”

Well, after reading the studies from Noé et al. and Föhse and colleagues about how the COVID-19 mRNA shots make an adult or child more prone to infections, I won’t be surprised if many people get infected.

Don’t Get Sick!

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References:

1. Noé et al. BNT162b2 COVID-19 vaccination in children alters cytokine responses to heterologous pathogens and Toll-like receptor agonists. Front. Immunol., August 25 2023. Volume 14 – 2023 | https://doi.org/10.3389/fimmu.2023.1242380
2. .Mina MJ, Metcalf CJ, de Swart RL, Osterhaus AD, Grenfell BT. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science. 2015 May 8;348(6235):694-9. doi: 10.1126/science.aaa3662. Epub 2015 May 7. PMID: 25954009; PMCID: PMC4823017.
3. Sørup S, Villumsen M, Ravn H, Benn CS, Sørensen TI, Aaby P, Jess T, Roth A. Smallpox vaccination and all-cause infectious disease hospitalization: a Danish register-based cohort study. Int J Epidemiol. 2011 Aug;40(4):955-63. doi: 10.1093/ije/dyr063. Epub 2011 May 4. PMID: 21543446.
4. Biering-Sørensen S, Aaby P, Lund N, Monteiro I, Jensen KJ, Eriksen HB, Schaltz-Buchholzer F, Jørgensen ASP, Rodrigues A, Fisker AB, Benn CS. Early BCG-Denmark and Neonatal Mortality Among Infants Weighing <2500 g: A Randomized Controlled Trial. Clin Infect Dis. 2017 October 1;65(7):1183-1190. doi: 10.1093/cid/cix525. PMID: 29579158; PMCID: PMC5849087.
5. Murphy DM, Cox DJ, Connolly SA, Breen EP, Brugman AA, Phelan JJ, Keane J, Basdeo SA. Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine. J Clin Invest. 2023 Jan 17;133(2):e162581. doi: 10.1172/JCI162581. PMID: 36282571; PMCID: PMC9843058.
6. Föhse K, Geckin B, Zoodsma M, Kilic G, Liu Z, Röring RJ, Overheul GJ, van de Maat J, Bulut O, Hoogerwerf J, Ten Oever J, Simonetti E, Schaal H, Adams O, Müller L, Ostermann PN, van de Veerdonk FL, Joosten LAB, Haagmans BL, van Crevel R, van Rij RP, GeurtsvanKessel C, de Jonge MI, Li Y, Domínguez-Andrés J, Netea MG. The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses. Clin Immunol. 2023 Sep 4:109762. doi: 10.1016/j.clim.2023.109762. Epub ahead of print. PMID: 37673225.

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