The FLCCC Weekly Webinar on April 13, 2022, featured Dr. Jackie Stone, who talked about her use of silver for COVID-19. She spoke of her experience with silver nanoparticles for COVID-19 at 24:58 here.
What is the science behind colloidal silver against infections?
A study published in the journal Antibiotics showed that colloidal silver is effective against 270 gram-negative and gram-positive bacteria strains, including multi-drug resistant strains. [1]
Silver nanoparticles and SARS-CoV-2
An in vitro study from the Yokohama City University School of Medicine evaluated different sizes of silver nanoparticles from 10 to 100 nm (nanometers). SARS-CoV-2 viruses were introduced to VeroE6 (non-human origin) and Calu-3 (human lung epithelial cell) cell lines in the survey.
They found that diameter particles around ten nm effectively inhibited extracellular SARS-CoV-2 at concentrations ranging between one and ten ppm (parts per million).
However, mammalian cell death (cytotoxicity) was observed at 20 ppm and above concentrations.
They also demonstrated that silver nanoparticles (AgNPs) potently inhibited viral entry by disrupting viral integrity. Leading them to conclude that silver nanoparticles are highly potent microbicides against SARS-CoV-2. (Ag is the chemical symbol of silver, Argenti in Latin.)
It is presumed that AgNPs exert their antiviral effect on SARS-CoV-2 by disrupting the disulfide bonds on the spike protein and ACE2 receptors.
However, they advised that it should be used with caution due to its cytotoxic effects at 20 ppm.
Silver nanoparticles for preventing COVID-19 in health care workers
A study assessed the effects of mouthwash and nose rinse with ARGOVIT® silver nanoparticles (AgNPs) to prevent SARS-CoV-2 in health care workers at the General Tijuana Hospital in Mexico. [4]
What is Argovit®?
ARGOVIT® Silver Nanoparticle is from the Investigation and Production Center Vector-Vita Ltd., made in Novosibirsk, Russia. It contains metallic silver, polyvinylpyrrolidone, hydrolyzed collagen, and distilled water. ARGOVIT® has been registered in Russia as an oral and nasal hygiene product since 2015.
According to another paper, the average size of the silver particles is about 1.5-2 nm for Argovit, Antibacterial medicines obtained by using silver nanoparticles.
The research from Mexico was a prospective randomized study of 231 participants that was carried out for nine weeks during the declaration of the COVID-19 pandemic. [4]
The study group was instructed to do mouthwash and nose rinse with the AgNPs solution; the control group was asked to do mouthwashes and nose rinse conventionally.
Individuals from the experimental group were provided with a 50 mL spray bottle containing silver nanoparticles solution with one wt% concentration (0.6 mg/mL metallic silver). They were instructed to mix 4 to 6 spray shots (corresponding to volume ~ 0.5 mL) of this solution with 20 mL of water and to gargle with the obtained solution for 15 to 30 seconds at least three times a day, also nasal lavages on the inner part of the nasal alae and nasal passage.
Many are probably wondering about equivalent parts per million (ppm) used since their unit is mg/ml. I calculated the corresponding ppm to be 15 ppm by the following: (0.6 mg/mL metallic silver) multiplied by 0.5 ml equals 0.3 mg/ml. Then divide 0.3mg/ml by 20 ml (water) which results in 0.015 mg/ml. Then convert mg/ml to ppm by going to the ENDMEMO website.
Amazon sells Triquetra Colloidal silver has Nano ions and has 30 PPM.
As an Amazon Associate, I earn from qualifying purchases.
Results
The incidence of SARS-CoV-2 infection was significantly lower in the “experimental” group (two participants of 114, 1.8%) compared to the “control” group (thirty-three participants of 117, 28.2%), with an 84.8% efficiency. [4]
There were no adverse reactions reported by those who used AgNPs.
Their in-vitro test showed an 80% reduction in viral replication in Vero E6 cell cultures in the same study.
The anti- SARS-CoV-2 properties of silver
The review article, Silver nanoparticle-based multifunctional approach for combating COVID-19, has a drawing showing the antimicrobial effects of silver.
The review also mentioned that silver might restrain severe inflammation and cytokine storms, thus preventing Acute Respiratory Distress Syndrome and lung fibrosis in COVID-19.
Toxicology of silver
The article by Wadhera and colleagues in Dermatology Online Journal [6] said,
The Environmetal Protection Agency publishes an oral reference dose (RfD) that is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. This dose is expressed in units of micrograms per kg per day and is an estimate of the maximum amount of daily silver exposure to the human population that is not associated with any appreciable deleterious effects over a lifetime.
The current RfD for oral silver exposure is 5 micrograms per kg per day. When consumed in relatively smaller quantities, no pathologic changes or inflammatory reactions other than argyria have been shown to result from silver deposition
If the patient has been exposed to silver nitrate instead, the cumulative dosage needed to produce argyria has been reported to be around 6 grams.
Emphasis added.
The dose administered in the Mexican study among health care workers is 0.9 mg/day. 1 gram is 1,000 mg.
Argyria
Argyria is a rare condition associated with chronic exposure to silver-containing products; it involves the deposition of silver granules in the skin, mucous membranes, and internal organs including the central nervous system. In skin, silver is mostly deposited around adnexal structures in the dermis; it is associated with a bluish-gray to slate-gray hue. This discoloration is thought to result from the presence of silver and a silver-induced increase in melanin concentration.
The effect is most pronounced in sun-exposed areas such as the face, neck, arms, and dorsum of the hands, but it can also be seen in fingernails (azure lunulae), conjunctival membranes, and oral mucosa.
Silver deposition and hyperpigmentation of the skin in argyria is permanent and primarily of cosmetic significance, and it has no effective treatment.
Conclusion
Only one study shows that silver nanoparticles prevent COVID-19, and the study size is small. More studies need to be made. However, numerous articles show the antimicrobial effectiveness of silver nanoparticles.
My experience with silver is when I had a patient who had a small cut on her finger that will not heal. She applied this product, Angels Colloidal Silver Gel and the wound closed in minutes. The reason is that silver kills any germs that were there that prevented the sound healing.
Supply chains are strained right now. The time may come when common antibiotics may not become available. Small cuts and infections can become life-threatening if not treated early. Knowledge about silver nanoparticles can be valuable when that time comes.
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References:
- Vila Domínguez A, Ayerbe Algaba R, Miró Canturri A, Rodríguez Villodres Á, Smani Y. Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria. Antibiotics (Basel). 2020;9(1):36. Published 2020 Jan 19. doi:10.3390/antibiotics9010036
- Jeremiah SS, Miyakawa K, Morita T, Yamaoka Y, Ryo A. Potent antiviral effect of silver nanoparticles on SARS-CoV-2. Biochem Biophys Res Commun. 2020;533(1):195-200. doi:10.1016/j.bbrc.2020.09.018
- Allawadhi P, Singh V, Khurana A, et al. Silver nanoparticle-based multifunctional approach for combating COVID-19. Sens Int. 2021;2:100101. doi:10.1016/j.sintl.2021.100101
- Almanza-Reyes H, Moreno S, Plascencia-López I, Alvarado-Vera M, Patrón-Romero L, Borrego B, et al. (2021) Evaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: In vitro and in vivo. PLoS ONE 16(8): e0256401. https://doi.org/10.1371/journal.pone.0256401
- Wadhera, A., & Fung, M. (2005). Systemic argyria associated with ingestion of colloidal silver. Dermatology Online Journal, 11(1). http://dx.doi.org/10.5070/D30832g6d3 Retrieved from https://escholarship.org/uc/item/0832g6d3
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