A case report presented a 64-year-old man with persistent shingles three after the Pfizer BNT162b2 injection.
The report was published in the Journal of Cutaneous Immunology and Allergy.
Shingles is due to a reactivation of a Varicella-Zoster Virus (VZV). The same virus causes chickenpox.
After a chickenpox infection, the VZV virus manipulates the immune system so that instead of being destroyed, it becomes tolerated and stays in the body. The VZV hides in the dorsal root ganglia. A nerve body located in the spinal cord.
If the immune system gets depressed, like in emotional stress or another disease, the VZV “reawakens” to replicate again and infects a nerve tract or a dermatome. This time, the VZV infection is called shingles.
That is why shingles lesions follow the path of a nerve from the cranial or spinal cord and typically appear only on one side of the body.
You can learn more about shingles at Shingles after COVID-19 Vaccination.
Case report
A 64-year-old man has rheumatoid arthritis, for which he takes medicines. He takes prednisolone and tacrolimus daily and methotrexate weekly.
He developed painful skin eruptions in both legs and hands 13 days after the first dose of the Pfizer mRNA COVID-19 shot. The lesions got worse after his second Pfizer shot.
Source: Yamamoto et al. Persistent varicella-zoster virus infection following mRNA COVID-19 vaccination was associated with the presence of encoded spike protein in the lesion. Journal of Cutaneous Immunology and AllergyThe patient consulted a skin specialist. He did not have a fever or any systemic symptoms.
Blood work did not show any abnormal blood counts, liver, or renal dysfunction except for a mild increase of d-dimer, suggesting abnormal coagulation.
He was diagnosed with shingles and treated with valacyclovir (1000 mg daily for five days). Valacyclovir is an antiviral for shingles. However, it was only “marginally effective.”
Typically, one regimen of antivirals is effective in taking care of shingles.
Because of the persistent lesions, they took biopsies from the skin lesions. Based on the microscope findings, he was diagnosed with a necrotizing vasculitis, a severe inflammation of the blood vessels.
Eighty-eight days after the disease onset, some lesions turned into necrotic nodules (Figure A below). A new group of vesicles on red macules developed in both legs (2B).
At the back of his right knee (popliteal fossa) was a tender, palpable, cord-like subcutaneous nodule suspected to be a superficial vein with a blood clot (superficial thrombophlebitis) which explains the high d-dimer test.
Another biopsy was done. This time immunostaining was positive using antibodies against VZV. That means VZV is still present.
To double-check, a polymerase chain reaction (PCR) test confirmed VZV’s presence. This time he was treated with a higher and longer dose of valacyclovir (3000 mg daily for seven days)
By this time, the dermatologists suspect that the Pfizer shot had something to do with this unusual case. So their next test was to immunostain using anti-coronavirus spike protein antibodies.
To their surprise, spike proteins were present in the skin lesions, the inflamed blood vessels in the dermis, and the small veins in the subcutaneous fat under the shingles lesions.
To be sure that the positive anti-spike protein test is vaccine-related and not due to the shingles, they did the same immunostaining on another patient who had shingles which is not vaccine-related. No spike proteins were detected. That means the positive anti-spike protein test on their case report is due to a spike protein.
Unusual case
This case of shingles is unusual because of three reasons. One, the shingles appeared in several parts of the body. Two, there is necrotizing vasculitis. And three, there are superficial thrombophlebitis-like lesions, which last for three months.
Typically, shingles present only on one side of the body, have no blood vessel inflammation, and last less than a month.
According to the authors, the mRNA vaccine could have suppressed T cell-mediated immunity due to the presence of the methyl-pseudouridines substituted for the uridines to stabilize the mRNA in the Pfizer shot.
The methyl-pseudouridines could have resulted in the continuous production of the spike protein by the body and caused chronic inflammation.
Another factor that contributed to the persistence of the shingles for three months is the intake of immunosuppressants for rheumatoid arthritis.
In summary, this case report presented shingles skin lesions that lasted for three months despite antiviral therapy. On top of the shingles, blood vessel inflammation and blood clothing were also present.
There is a good chance that the Pfizer COVID injection had something to do with the prolonged shingles due to spike proteins in the lesions.
If the spike protein is present in the shingles, it may also be present in other parts of the body and continue to elicit an inflammatory reaction.
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Thank you so much!
mejbcart has a brand new Substack post on URIDINE. What impeccable timing! So few people realy the importance of uridine.
https://mejbcart.substack.com/p/the-importance-of-d-uridine-the-nicotine/comments
Thabks again!