Diseases Associated with the Metabolic Syndrome

Posted on by Jesse Santiano, M.D.

This article lists the diseases associated with metabolic syndrome (MetS). Anyone with three or more of the following five conditions—hypertension, high blood sugar, high blood triglycerides, low HDL, and obesity—qualifies for a diagnosis of MetS.

Any single condition in the five components of MetS produces many other reactions that interact with the effects of the other parts of MetS. For example, obesity produces different kinds of inflammatory cytokines that will interact with the free radicals resulting from high blood sugar.

Hypertension leads to low nitric acid production. A small or ineffective nitric oxide leads to damage to the lining of the blood vessels, leading to more hypertension, thereby creating a vicious cycle.

Any of these interactions leads to organ dysfunction. Once a body organ is affected, the symptoms referable to that organ are present.

For example, gastric reflux will present as heartburn, and damage to the blood vessels will present as a heart attack or stroke. Thus, the main culprit, visceral fat accumulation, insulin resistance, hypertension, and dyslipidemia, remains hidden.

This list is incomplete and may take time because the more I research, the more I find. Other diseases are without articles but will have their own in the future. The words in blue have a hyperlink to the article for more details.

Top Causes of Mortality

  1. Ischemic Heart Disease
  2. Stroke
  3. Chronic Obstructive Pulmonary Disease
  4. Pneumonia
  5. Alzheimer’s Disease
  6. Diabetes Mellitus
  7. Cancers
  8. Kidney Disease

Heart

  1. Heart Attacks
  2. Atrial fibrillation

Lungs

  1. Shortness of Breath/ Abnormal Lung Function
  2. Tuberculosis
  3. Asthma
  4. Chronic Obstructive Pulmonary Disease, Emphysema
  5. Obstructive Sleep Apnea

Gastro-Intestinal

  1. Gastroesophageal Reflux Disease GERD (heartburn)
  2. Liver
    1. Fatty Liver
    2. Hepatocarcinoma
  3. Gallbladder
    1. Gallstones
    2. Acute Cholecystitis
    3. Gallstone Pancreatitis
    4. Choledocholithiasis (Stones in the Bile Duct)
    5. Cholangitis
  4. Pancreas
    1. Pancreatitis
    2. Fatty Pancreas
    3. Pancreatic Cancer
  5. Inflammatory Bowel Diseases
    1. Crohn’s Disease

Kidney Stones

Joint Problems /Arthritis

  1. Osteoarthritis – The most common arthritis
  2. Rheumatoid Arthritis
  3. Psoriatic Arthritis
  4. Gout

Skin Disorders

  1. Skin tags
  2. Psoriasis
  3. Dark Skin Patches/ Actinic Keratosis
  4. Acne
  5. Hair Loss

Ears

  1. Vertigo
  2. Tinnitus
  3. Sensorineural Hearing Loss

Eyes

  1. Retinopathy
  2. Cataracts
  3. Open-angle Glaucoma
  4. Central Retinal Artery Occlusion

Female reproductive system

  1. Polycystic Ovarian Syndrome (PCOS) and Infertility
  2. Menstruation Issues, Irregular periods
  3. Ovarian Cancer
  4. Endometrial Cancer
  5. Cervical Cancer

Male Genitourinary Disorders 

  1. Benign Prostatic Hyperplasia
  2. Erectile Dysfunction

Cancer 

  1. Esophagus,
  2. Colon and rectum
  3. Liver
  4. Gallbladder
  5. Pancreas
  6. Kidney
  7. Non-Hodgkin’s lymphoma
  8. Multiple myelomas
  9. Stomach
  10. Prostate
  11. Breast
  12. Uterus
  13. Cervix,
  14. Ovary

Periodontal Disease

Coagulation Disorders

  1. Deep Venous Thrombosis
  2. Atrial Fibrillation
  3. Pulmonary Embolism (Blood Clots in the lungs)

Brain

  1. Alzheimer’s Dementia
  2. Parkinson’s Disease
  3. Ischemic Strokes

There are other causes for the diseases mentioned above other than the metabolic syndrome. Any three of the five components of the Metabolic Syndrome enumerated above, or any other conditions listed may put you at risk for cardiovascular disease.

That is because any of the diseases mentioned above are associated with MetS. Consult your physician to assess your risk for heart disease and prevent it as early as possible.

Lifestyle changes like intermittent fasting, low sugar and low carbohydrate diet, and exercise are simple, inexpensive (actually will save you money), and within reach to everybody.

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Related Readings:

  1. How to Do Intermittent Fasting
  2. The Kaizen Way of Fasting
  3. What is Insulin Resistance?
  4. Hyperinsulinemia
  5. What is the Goal of Diabetes Treatment?
  6. I’m Only Pre-Diabetic, So I’m Still OK, Right?
  7. How Will You Know if You are TOFI?
  8. Can You be Skinny and Obese?
  9. What Does Waist Circumference Really Measure?
  10. Why Do Bellies Bloat?

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