Why COVID Vaccine Immunity Fade: New Discovery

This article presents studies that explain why immunity derived from COVID-19 infection and its jabs does not last long.

Introduction

Scientists have finally solved one of COVID-19’s most puzzling mysteries: why vaccine protection fades so quickly.

A groundbreaking study, SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination,  reveals that, unlike traditional vaccines, COVID-19 shots fail to create the crucial long-lived cells in our bone marrow that maintain lifelong immunity.

The results concur with those of previous research, Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection,  this time on people who had previously experienced COVID-19 and had waning immunity.

Both results solve a puzzle that has confused scientists since the pandemic began.

Key Findings Explained

The Bone Marrow Connection

Scientists discovered that COVID-19 vaccines fail to generate crucial long-lived plasma cells (LLPCs) in bone marrow, unlike traditional vaccines for diseases like tetanus and influenza.

These cells are essential for maintaining long-term antibody production.

The Evidence

The first study, examining bone marrow samples from 19 healthy adults who received mRNA vaccines, found stark differences between COVID-19 immunity and protection against other diseases.[1]

While vaccines for influenza and tetanus successfully created stable populations of long-lived plasma cells (LLPCs) in the bone marrow, COVID-19 vaccines primarily generated short-term antibody factories.

The Numbers Tell the Story

The research revealed striking differences:

• Tetanus vaccine: Ratio of short-lived to long-lived cells = 0.44:1
• Influenza vaccine: Ratio of short-lived to long-lived cells = 0.61:1
• COVID-19 vaccine: Ratio of short-lived to long-lived cells = 29.07:1

A second independent study of 20 individuals with previous COVID-19 infections confirmed these findings. Their bone marrow samples showed the striking absence of long-term antibody-producing cells specific to the virus’s spike protein.[2]

Study Details

1. First Study:[1]
   • 19 healthy adults examined
   • Timeframe: 2.5–33 months post-vaccination
   • Measured antibody-secreting cells for multiple vaccines
   • Compared COVID-19, influenza, and tetanus responses
   • In five individuals with recent SARS-CoV-2 infection and vaccination, SARS-CoV-2-specific ASCs remained scarce in the LLPC compartment. This finding agrees with the study below.
2. Second Study:[2]
   • 20 individuals with prior COVID-19 infection
   • Focused on bone marrow analysis
   • Examined plasma samples
   • Confirmed lack of spike-specific LLPCs

Why This Matters

This discovery has profound implications for public health. Traditional vaccines create what scientists call “immune memory” – permanent factories in our bone marrow that continuously produce protective antibodies for years or even decades.

These factories or “immune memories” are missing in COVID-19 vaccination, explaining why protection drops so quickly, typically within 3-6 months.

Real-World Impact

The findings explain several observed patterns:

1. Why antibody levels predictably fall months after vaccination
2. Why breakthrough infections become more common over time
3. Why regular boosters are necessary for maintaining protection
4. Why measuring antibody levels alone doesn’t tell the whole story

The Science Behind It

• Long-lived plasma cells act as immune system memory
• They continuously produce antibodies
• The absence of LLPCs after COVID-19 and its shots explains why protection fades

Clinical Significance

For Healthcare Providers

1. Explains observation patterns:
   • Why antibody levels drop
   • Timing of protection decline
2. Helps inform:
   • Vaccination strategies- limit to the high-risk only
   • Patient Education

For Public Health

1. Policy Implications:
   • Vaccination schedules
   • Risk assessment strategies
2. Communication Benefits:
   • Supports vaccine education
   • Addresses public concerns

Conclusion

This research provides a crucial understanding of why COVID-19 vaccine protection differs from traditional vaccines.

The absence of long-lived plasma cells in bone marrow explains why COVID-19 vaccine immunity wanes.

I wrote about the topic of short-lived immunity after the COVID-19 shots in:

• The Rise and Fall of Antibodies in Mild and Asymptomatic COVID-19
• Durable Immunity from Pfizer COVID-19 Vaccine Lasts Only Six Months
• Defective immunity and COVID-19 antibody-dependent enhancement in Alberta, Canada
• Study: Those Up-to-Date with the Shots Get More COVID-19

The studies reiterate the need for booster shots. A previous study has shown that booster shots don’t provide long-lasting immunity.

Repeated COVID booster shots Impair Immunity.

Would you buy brakes for your car if it only lasts for three months?

Furthermore, the mRNA shots increase the immune-tolerant antibody, IgG4. I wrote about the studies on that topic in:

1. mRNA COVID-19 Booster Shots Increase the Immunotolerant IgG4
2. Another Study Confirms the Rise of IgG4 after the mRNA shots
3. The Devastating Effects of IgG4 after the mRNA Shots shots
4. SAR-CoV-2 embedded in human cells, IgG4, Autoimmune Diseases and Cancer
5. Moderna and Pfizer COVID jabs Increase Anti-inflammatory IgG4
6. Three Studies Link High IgG4 to Severe COVID-19
7. Pfizer mRNA shots Switch Antibodies to Non-Neutralizing IgG4

And if you are thinking of using Paxlovid, consider the studies about them at:

• Paxlovid blunts adaptive immune response to SARS-CoV-2
• The Paxlovid Rebound Study

Maintain a healthy immune system with a healthy blood sugar level.

• Blood Sugar Crisis: The Truth About Organ Damage
• 102 Easy Ways to Lower Post-Prandial Blood Sugar Without Meds

Don’t Get Sick!

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References:

1. Nguyen, Doan C., et al. “SARS-CoV-2-specific Plasma Cells Are Not Durably Established in the Bone Marrow Long-lived Compartment After MRNA Vaccination.” Nature Medicine, 2024, pp. 1-10, https://doi.org/10.1038/s41591-024-03278-y. Accessed 16 Nov. 2024.
2. Zahra R Tehrani, Parham Habibzadeh, Robin Flinko, Hegang Chen, Abdolrahim Abbasi, Jean A Yared, Stanca M Ciupe, George K Lewis, Mohammad M Sajadi, Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection, The Journal of Infectious Diseases, Volume 230, Issue 1, 15 July 2024, Pages e30–e33, https://doi.org/10.1093/infdis/jiad603

Image credit: By Bobjgalindo – Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=7777568

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