This article presents studies that explain why immunity derived from COVID-19 infection and its jabs does not last long.
Introduction
Scientists have finally solved one of COVID-19’s most puzzling mysteries: why vaccine protection fades so quickly.
A groundbreaking study, SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination, reveals that, unlike traditional vaccines, COVID-19 shots fail to create the crucial long-lived cells in our bone marrow that maintain lifelong immunity.
The results concur with those of previous research, Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection, this time on people who had previously experienced COVID-19 and had waning immunity.
Both results solve a puzzle that has confused scientists since the pandemic began.
Key Findings Explained
The Bone Marrow Connection
Scientists discovered that COVID-19 vaccines fail to generate crucial long-lived plasma cells (LLPCs) in bone marrow, unlike traditional vaccines for diseases like tetanus and influenza.
These cells are essential for maintaining long-term antibody production.
The Evidence
The first study, examining bone marrow samples from 19 healthy adults who received mRNA vaccines, found stark differences between COVID-19 immunity and protection against other diseases.[1]
While vaccines for influenza and tetanus successfully created stable populations of long-lived plasma cells (LLPCs) in the bone marrow, COVID-19 vaccines primarily generated short-term antibody factories.
The Numbers Tell the Story
The research revealed striking differences:
- Tetanus vaccine: Ratio of short-lived to long-lived cells = 0.44:1
- Influenza vaccine: Ratio of short-lived to long-lived cells = 0.61:1
- COVID-19 vaccine: Ratio of short-lived to long-lived cells = 29.07:1
A second independent study of 20 individuals with previous COVID-19 infections confirmed these findings. Their bone marrow samples showed the striking absence of long-term antibody-producing cells specific to the virus’s spike protein.[2]
Study Details
- First Study:[1]
- 19 healthy adults examined
- Timeframe: 2.5–33 months post-vaccination
- Measured antibody-secreting cells for multiple vaccines
- Compared COVID-19, influenza, and tetanus responses
- In five individuals with recent SARS-CoV-2 infection and vaccination, SARS-CoV-2-specific ASCs remained scarce in the LLPC compartment. This finding agrees with the study below.
- Second Study:[2]
- 20 individuals with prior COVID-19 infection
- Focused on bone marrow analysis
- Examined plasma samples
- Confirmed lack of spike-specific LLPCs
Why This Matters
This discovery has profound implications for public health. Traditional vaccines create what scientists call “immune memory” – permanent factories in our bone marrow that continuously produce protective antibodies for years or even decades.
These factories or “immune memories” are missing in COVID-19 vaccination, explaining why protection drops so quickly, typically within 3-6 months.
Real-World Impact
The findings explain several observed patterns:
- Why antibody levels predictably fall months after vaccination
- Why breakthrough infections become more common over time
- Why regular boosters are necessary for maintaining protection
- Why measuring antibody levels alone doesn’t tell the whole story
The Science Behind It
- Long-lived plasma cells act as immune system memory
- They continuously produce antibodies
- The absence of LLPCs after COVID-19 and its shots explains why protection fades
Clinical Significance
For Healthcare Providers
- Explains observation patterns:
- Why antibody levels drop
- Timing of protection decline
- Helps inform:
- Vaccination strategies- limit to the high-risk only
- Patient Education
For Public Health
- Policy Implications:
- Vaccination schedules
- Risk assessment strategies
- Communication Benefits:
- Supports vaccine education
- Addresses public concerns
Conclusion
This research provides a crucial understanding of why COVID-19 vaccine protection differs from traditional vaccines.
The absence of long-lived plasma cells in bone marrow explains why COVID-19 vaccine immunity wanes.
I wrote about the topic of short-lived immunity after the COVID-19 shots in:
- The Rise and Fall of Antibodies in Mild and Asymptomatic COVID-19
- Durable Immunity from Pfizer COVID-19 Vaccine Lasts Only Six Months
- Defective immunity and COVID-19 antibody-dependent enhancement in Alberta, Canada
- Study: Those Up-to-Date with the Shots Get More COVID-19
The studies reiterate the need for booster shots. A previous study has shown that booster shots don’t provide long-lasting immunity.
Repeated COVID booster shots Impair Immunity.
Would you buy brakes for your car if it only lasts for three months?
Furthermore, the mRNA shots increase the immune-tolerant antibody, IgG4. I wrote about the studies on that topic in:
- mRNA COVID-19 Booster Shots Increase the Immunotolerant IgG4
- Another Study Confirms the Rise of IgG4 after the mRNA shots
- The Devastating Effects of IgG4 after the mRNA Shots shots
- SAR-CoV-2 embedded in human cells, IgG4, Autoimmune Diseases and Cancer
- Moderna and Pfizer COVID jabs Increase Anti-inflammatory IgG4
- Three Studies Link High IgG4 to Severe COVID-19
- Pfizer mRNA shots Switch Antibodies to Non-Neutralizing IgG4
And if you are thinking of using Paxlovid, consider the studies about them at:
Maintain a healthy immune system with a healthy blood sugar level.
- Blood Sugar Crisis: The Truth About Organ Damage
- 102 Easy Ways to Lower Post-Prandial Blood Sugar Without Meds
Don’t Get Sick!
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References:
- Nguyen, Doan C., et al. “SARS-CoV-2-specific Plasma Cells Are Not Durably Established in the Bone Marrow Long-lived Compartment After MRNA Vaccination.” Nature Medicine, 2024, pp. 1-10, https://doi.org/10.1038/s41591-024-03278-y. Accessed 16 Nov. 2024.
- Zahra R Tehrani, Parham Habibzadeh, Robin Flinko, Hegang Chen, Abdolrahim Abbasi, Jean A Yared, Stanca M Ciupe, George K Lewis, Mohammad M Sajadi, Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection, The Journal of Infectious Diseases, Volume 230, Issue 1, 15 July 2024, Pages e30–e33, https://doi.org/10.1093/infdis/jiad603
Image credit: By Bobjgalindo – Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=7777568
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