Update Jan 12, 2023: I added another reason. SARS-CoV-2 variants of concern developed resistance to interferon as the pandemic progressed.
Much new information came out recently about SARS-CoV-2, which causes COVID-19, the antivirals prescribed for it, and its “vaccines.”
This article aims to increase awareness that SARS-CoV-2 reinfections can happen no matter if they have received the COVID injections and had previous infections.
Although no indication says that the new subvariants are more deadly here in the US, alarming signals from China can change all that.
For those new to the website, my linked articles are in blue. All pieces are based on scientific studies, and the references are listed below.
1. Weakened innate immune system
A paper by Stephanie Seneff and Dr. Peter McCullogh hypothesized that SARS-CoV-2 mRNA vaccination reduces the Type I interferon response leading to an impaired antiviral response and increased risk of viral infections. [1]
We can see the results in the increased cases not only of COVID-19 but also RSV and influenza infections.
2. Non-inflammatory IgG4 from Pfizer mRNA shots
A study from the Institute of Clinical and Molecular Virology in Germany and published in Science Immunology shows IgG4, a subclass of immunoglobulin G (IgG), increases several months when the memory B cells in the germinal centers mature.[2]
IgG4 is non or even anti-inflammatory. It usually shows up after allergy desensitization. This makes people with the Pfizer shots susceptible to future SARS-CoV-2 infection because their immune systems will not kill the virus.
I discussed that in Pfizer mRNA shots Switch Antibodies to Non-Neutralizing IgG4.
There is evidence that people with abnormally high levels of IgG4 can have severe COVID-19. — Three Studies Link High IgG4 to Severe COVID-19
3. Blunted adaptive immunity to SARS-CoV-2 due to Paxlovid
Paxlovid is one of the antivirals recommended by the Centers for Disease Control and Prevention.
A preprint study from the Raffaele Scientific Institute in Milan, Italy, showed that intake of nirmatrelvir, the active ingredient in Paxlovid, during COVID-19 blunts the development of specific antibody and T cell responses. [3]
In the study, mice given nirmatrelvir during the first infection and rechallenged with SARS-CoV-2 had significantly fewer memory T and B cells in the infected lungs and mediastinal lymph nodes, respectively.
Paxlovid blunts adaptive immune response to SARS-CoV-2
The authors explain that Paxlovid wipes out the virus very well, so no viral material is left for the adaptive immune system to work on to develop memory cells.
Unsurprisingly, many like Dr. Anthony Fauci, President Joe Biden, and CDC Director Dr. Rochelle Walensky have rebound COVID-19.
COVID-19 reinfections after Paxlovid intake has been verified by a prospective study [4] that is discussed in The Paxlovid Rebound Study
Another issue is that it has been shown that SARS-CoV-2 can develop immunity against Paxlovid in cell cultures. It is not far-fetched now that it may happen in real situations.[11]
4. Loss of Vaccine Effectiveness
The standard for COVID vaccine effectiveness was established by the Food and Drug Administration and the World Health Organization to be 50% and above.
A multinational study was released yesterday by BioRxiv. It estimated the effectiveness of COVID vaccine boosters against SARS-CoV-2 variants.[5]
They predict an almost complete loss of protection against mild COVID-19 after one year.
- 7.8% for AstraZeneca AZD1222
- 3.2% for Pfizer BNT162b2
- 16.7% for Moderna mRNA-1273
Even the bivalent booster shots designed against the Omicron have proven ineffective — CDC data: Sub-par efficacy of the Bivalent COVID shots.
Even the monovalent booster shots have waning neutralizing antibodies.
- Breakthrough infection provides greater protection than a booster shot
- Breakthrough infections after two shots: 50% in 1 month, 75% in 3 months.
5. COVID-19 reinfections with Molnupiravir
COVID-19 rebound is also observed with molnupiravir (Lagevrio™), another antiviral also recommended by the CDC for COVID-19.
A study by Case Western University showed findings consistent with Pandit et al. that proved that rebound could happen with Paxlovid.
Additionally, the risk for reinfections is similar to molnupiravir, especially for those with underlying medical conditions. The ones that need the most protection.[6]
Another study published in Lancet reiterated that molnupiravir did not reduce the frequency of COVID-19 hospitalizations or death among high-risk vaccinated adults.[7]
6. SARS-CoV-2 mutations with Molnupiravir use
The findings of the study from the Royal Hobart Hospital in Australia are probably one that is far-reaching and most significant.[8]
In five immune-compromised patients who were given molnupiravir for COVID-19, they detected hundreds of SARS-CoV-2 mutations. Here is the exact quote from their abstract.
Within days of treatment, we detected a large number of low-frequency mutations in patients and that these new mutations could persist and, in some cases, were fixed in the virus population.
All patients treated with the drug accrued new mutations in the spike protein of the virus, including non-synonymous mutations that altered the amino acid sequence.
Our study demonstrates that this commonly used antiviral can ‘supercharge’ viral evolution in immunocompromised patients, potentially generating new variants and prolonging the pandemic.[8]
Those SARS-CoV-2 mutations do not stay within the immune-compromised patients. They spread to the community.
Read more about it at Molnupiravir Causes Hundred of SARS-CoV-2 Mutations
These mutations lead to the next reason why COVID-19 will increase again.
7. New variants are antibody resistant with Higher ACE2 avidity
The dominant Omicron subvariant in the US is XBB.1.5, causing 41% of COVID-19. I wrote about it yesterday.
Scientists from Peking University and the Chinese Academy of Sciences closely looked at the XBB.1.5. The title of my article bears their findings.
The Dominant Omicron XBB1.5 Evades Antibodies and has Stronger ACE2 Binding.
As the infomercials say, “But wait, there’s more!’ (highly infectious variants and antibody-resistant variants)
A study published in Cell on December 13, 2022, showed that the SARS-CoV-2 variants BQ.1, BQ.1.1, XBB, and XBB.1 are the most resistant to antibodies from vaccination, including the boosters.[10]
On top of that, monoclonal antibodies were also inactive against them. At the same time, they retained their ability to attach to the ACE2 receptors. Some details from their abstract.
In China, where molnupiravir has been used since September 2022, the most dominant variant is the Omicron BF.7.
In a Global Times interview, Li Tongzeng, a medical expert at Beijing’s Xiaotangshan Hospital, said,
BF.7 has more immune escape capability, a shorter incubation period, and a faster transmission rate.
“The basic reproduction number (R0) for Delta variant is around 5 to 6, that of Omicron BF.7 has exceeded 10
The R0 of the current Omicron BF.7 in Beijing can reach from anywhere between 10 to 18.6 persons, according to Li.
R0 is also known as the secondary attack rate. A R0 of 10 to 18.6 means one sick person can infect ten to 18.6 more people. The newly infected people can then infect 100 to 346 (18.6×18.6) more.
8. How is COVID-19 in China?
No one knows exactly how bad COVID-19 is in China. Jennifer Zeng is known to be a reliable reporter of what is happening in China. She has posted several troubling videos about COVID-19 in China.
Here is a long line to a crematorium.
At Zhangjiagang, Suzhou City crematorium. Early in the morning, long line of funeral cars queuing. This is already 1 km away from the crematorium. #CCPChina #ChinaCovidCases #ChinaCovidDeaths #ChinaCovidSurge pic.twitter.com/LHM1Yko8Z0
— Inconvenient Truths by Jennifer Zeng 曾錚真言 (@jenniferzeng97) January 3, 2023
Another video shows a congested emergency department overflowing to the street. I have worked in busy emergency rooms, but not on the streets!
At, oh, no, outside a hospital in #Beijing, patients receive treatments on the street as there is no more space inside.#chinacovid #ChinaCovidCases #ChinaCovidSurge #ChinaCovidDeaths #ChinaCovidNightmare #COVID #COVID19 #ZeroCovid #CCPVirus #CCP #China #CCPChina#ChinaCovidNews pic.twitter.com/KhVOVyvRvV
— Inconvenient Truths by Jennifer Zeng 曾錚真言 (@jenniferzeng97) January 3, 2023
The next one is a quarantine camp being converted into a large crematorium. Ignore the funny song.
Jan 2, at Yiyang City, #Hunan Provincem #CCPChina, urgent expansion of a #crematorium. I am sorry for the funny song. Not added by me.#chinacovid #ChinaCovidCases #ChinaCovidSurge #ChinaCovidDeaths #ChinaCovidNightmare #COVID #COVID19 #ZeroCovid #CCPVirus #CCP #China #CCPChina pic.twitter.com/MRVPfuxgLf
— Inconvenient Truths by Jennifer Zeng 曾錚真言 (@jenniferzeng97) January 4, 2023
We are in the dark because China was not submitting SARS-CoV-2 sequences to GISAID (Global Influenza Surveillance and Response System). Is there a deadlier variant in China?
As of this writing, GISAID is having problems with its site, but when I looked yesterday at how many SARS-CoV-2 sequences China submitted, it is only in the four digits while the US is in the millions.
That is why the World Health Organization said China’s COVID numbers are ‘not very credible’ and asked for a ‘more realistic picture.’
In an Epoch Time Report, Mike Ryan, the World Health Organization’s Emergencies Director, told reporters at a media briefing on Jan. 4.
We believe that the current numbers being published from China under-represent the true impact of the disease in terms of hospital admissions, in terms of ICU admissions, particularly in terms of death.
“And we would like to see more data on a more geographic basis across China.”
In a report today, GISAID said that the latest data from China resembles known circulating variants. BF.7 outbreaks in Beijing and Fujian and ongoing BA.5.2 in multiple cities.
Hmm. As Ronald Reagan said, “Trust but confirm.”
The US recently made it a policy to test visitors from China. I agree with that for the sake of public health. The positive results should also be sequenced.
Canada, Australia, India, Japan, and several European countries are doing the same.
10. Winter weather
It is winter now in the northern hemisphere, and people are more confined together. The Christmas blizzard that affected several US states caused a driving ban for almost a week where I live.
The once-in-a-generation weather confined millions together in houses that are shut closed due to subfreezing temperatures outside. Who knows how many were exposed to different variants brought by families from out of state?
And after being together for several days, visitors return to their homes and work out of state and spread the viruses.
I’m not being anti-social here, just showing how disease spreads naturally.
11. Imperfect vaccines
The Pfizer, Moderna, AstraZeneca, and Janssen vaccines used in the US do not block infection. That is what Deborah Birx, former White House COVID response coordinator said. Many vaccinated readers know that by now, after having breakthrough infections.
Two pre-COVID papers found that imperfect vaccines lead to deadlier viruses and severe disease in unvaccinated individuals.[12][13]
12. Refusal of effective medications
Suppose you are faced with a highly transmissible virus, and the vaccines, recommended antivirals, and hospital treatment protocol don’t work.
Would you try an alternative medicine that is safe and proven to work based on 93 studies, like ivermectin?
Yes sounds like the logical answer, but I know at least two people who won’t. There are more, I’m sure.
Tim Robbins said that COVID is a new religion. Oh yeah! A false one, indeed.
13. Interferon Resistance of SARS-CoV-2 variants
A study found that as the SARS-CoV-2 variants emerged, they became more resistant to interferon.[14]
Interferons are antivirals produced by the immune system. There are several types of interferon (IFN) like the Type I IFN and Type III IFN and their subtypes) to meet the diverse array of viruses the body must confront.
The study authored by scientists from the Department of Medicine of the University of Colorado Anschutz Medical Campus compared 17 human interferons against the ancestral and five SARS-CoV-2 variants of concern.
They include the USA-WA1/2020, isolated from the first COVID-19 patient in the United States, who had a direct link to Wuhan, China, and the B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.617.2 (Delta), and B.1.1.529 (Omicron) lineages.
They found that the SARS-CoV-2 variants have a higher interferon resistance, suggesting that they can evade the innate immune system, the front-line defense against infection. [14]
The graphs below show the increasing interferon resistance by the SARS-CoV-2 variants.
As of now, all of the major circulating variants worldwide belong to the Omicron lineage. The developed interferon resistance and other factors mentioned in this article explain the pandemic’s persistence despite developing antibodies from the vaccines and natural immunity. However, the authors did not mention if the interferons that they used were from the vaccinated or unvaccinated.[14]
All variants except for the Alpha circulated and were designated variants of concern in 2021, the year of the SARS-CoV-2 vaccine roll-out.
If there had been more interferon resistance among the vaccinated, that would have confirmed the theory of Seneff and colleagues, who said that the mRNA shots could lead to “profound impairment in type I interferon signaling.” [1]
Interferon is also involved in cancer surveillance and elimination. The increased interferon resistance can contribute to the rise in cancer rates.
An article in Nature published in October 2022 shows an emerging global epidemic of early-onset cancer in adults less than 50 years old.[15]
If you want to learn more about how to improve your chances against COVID-19:
- The I-PREVENT COVID Protection Protocol
- The FLCCC I-CARE Early COVID Treatment Protocol
- What should the household do if someone has Early COVID-19?
- How ordinary mouthwashes kill the SARS-CoV-2
- A better technique for nasal sprays
- Zinc for COVID-19
- Melatonin prevents SARS-CoV-2 damage to the brain
- Nasal rinse and deep gargle stop viral respiratory infections in their tracts
- Bromhexine for COVID-19
- Echinacea for the Prevention and Treatment of Viral Respiratory Infections and COVID-19
- Aspirin for the early treatment of COVID-19
- Curcumin for the Early Treatment of COVID-19
- Nigella Sativa or Black Seed, Black Cumin for COVID-19
- Povidone Iodine Works Great for the Prevention and Early Treatment of COVID-19!
- Ivermectin is Effective against the Influenza and a Cold Virus In Vitro
- Melatonin’s Multiple Actions Against COVID-19
- A new study shows a 100% decreased hospitalization rate with regular ivermectin use
- Ivermectin prevents binding to human cells by blocking the spike protein
- The many problems of the Ivermectin study in the NEJM
- City-wide use of Ivermectin lowered COVID-19 cases, hospitalizations, and deaths in Itajaí, Brazil
- What makes Ivermectin a kick-ass antiviral?
Don’t Get Sick!
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