Defective immunity and COVID-19 antibody dependent enhancement in Alberta, Canada

This article shows graphs made from data from Alberta, Canada. The graphs say a lot, and they show that people who get COVID shots are prone to get sick, hospitalized, or die from COVID-19 weeks or months after the shot.

It has to do with the vaccine, antibody-dependent enhancement, and immune deficiency.

Why is that?

What’s in the mRNA shots?

The SARS-CoV-2 is made of RNA, and so are the mRNA vaccines like Pfizer and Moderna. If RNA is injected into the body, the immune response easily destroys it, which is why the shots are coated with a lipid nanoparticle.

Another way is to add a methyl group or methylate some of the nucleotides in the RNA. Methylation allows the RNA to escape the immune response, but there is a side effect.

The methylation can suppress the innate immune response. Kariko and colleagues discovered this in 2005. They showed that methylated RNA prevents the stimulation of immune cells from fighting infection. Below is a quote from their abstract. Emphasis and links added. [2]

We show that RNA signals through human Toll-like receptor 3 TLR3, TLR7, and TLR8, but incorporation of modified nucleosides 5-methylcytosine m5C, N6-methyladenosine or m6A, 5-methyluridine m5U, 2-thiouracil s2U, or pseudouridine ablates activity.

Dendritic cells (DCs) exposed to such modified RNA express significantly less cytokines and activation markers than those treated with unmodified RNA.

We conclude that nucleoside modifications suppress the potential of RNA to activate Dendritic Cells.

Dendritic cells are members of the immune cells are professional antigen-presenting cells that patrol the body, sites of infection, or infiltrate diseased tissues to look for antigens that can be used to activate the effector cells. They are a bridge between the innate and adaptive immune systems.

What COVID shots contain methylated RNA?

Pfizer and Moderna are the most commonly used COVID shots approved in Canada and the US.

https://health-infobase.canada.ca/covid-19/vaccine-administration/

Both contain pseudouridine, m6A, and s2U is in the mRNA. [3] Park and colleagues did a review about the mRNA shots [4],

For all the seven reported vaccines, pseudouridine was incorporated into the mRNA vaccines in the place of uridine. In addition, the substitution with pseudouridine, m6A, and s2U in RNA molecules suppresses the degradation of RNA by ribonuclease L RNase L ⁵. Thus, the nucleoside modifications not only enhance the stability of RNA but also reduce the innate immune response.

To be precise, N1-Methylpseudouridine m1Ψ is the pseudouridine in the vaccines. It increases (spike) protein production. Andries and his group also mentioned that it diminishes the innate immune response [5]

The enhanced capability of (m5C/)m1Ψ-modified mRNA to express proteins may at least partially be due to the increased ability of the mRNA to evade activation of endosomal Toll-like receptor 3 (TLR3) and downstream innate immune signaling.

The innate immune response is essential in warding off infections. Anything that will prevent the immune cells from detecting and warding off infections results in higher susceptibility to viral infections like COVID-19. The innate immune system also prepares the adaptive immune system, and if the innate system is not working well, the adaptive cannot function properly.

The Alberta COVID-19 Experience

The graphs below show the number of COVID-19 cases, hospitalizations, and deaths among the vaccinated in Alberta, Canada. It is color-coded into age groups. I got it from The Wayback Machine, and that’s because the Alberta website scrubbed it after Alex Berenson reported about it.

These are COVID-19 hospitalizations and not due to immunization adverse events.

The number 0 on the x-axis or horizontal line was when the person received the jabs. Notice that most COVID-19 cases, hospitalizations, and deaths among the vaccinated happened within 40 days when their immune system is at its weakest after the shots. It happens in all ages.

Remember 40 days because it will show up later.

The Second COVID shot

The three graphs below show the COVID-19 cases, hospitalizations, and deaths after the second COVID shot. The same increase in cases, hospitalizations, and deaths happen. Notice the small increase in the numbers before 20 days. We will get to the 140 days later.

Significance

First, the graphs show that immune deficiency is a clinical reality when methylated RNA is injected into people, evidenced by the rise in cases, hospitalizations, and deaths for several weeks after the shots.

Second, by definition of the CDC, all COVID-19 cases, hospitalizations, and deaths will be counted under the unvaccinated group.

Why is that?

Definition of Vaccinated

According to the Centers for Disease Control and Prevention,

In general, people are considered fully vaccinated:

2 weeks after their second dose in a 2-dose series, such as the Pfizer or Moderna vaccines, or

2 weeks after a single-dose vaccine, such as Johnson & Johnson’s Janssen vaccine

If you don’t meet these requirements, regardless of your age, you are NOT fully vaccinated. Keep taking all precautions until you are fully vaccinated.

The Alberta government has the same definition of fully immunized.

Length of the defective immune response

Someone injected with the COVID shots can be immune-compromised and prone to infections for as long as six weeks or a month and a half. That’s because people who had the Pfizer shot have to wait for three weeks (21 days) for the second shot, and the Moderna people have to wait for four weeks (28 days) to have a second shot.

That means the Pfizer group and the Moderna people may be immune-deficient for 35 and 42 days, respectively, from the first day they had a shot. Recall that the number of COVID-19 cases, hospitalizations, and deaths are high in the first 40 days.

The waning of antibody effectiveness

There is more to the data. Take a look again at the second shot graphs. Notice the rise in cases, hospitalization, and deaths after 140 days.

Ninety days to six months after the shots, the vaccine-induced neutralizing antibodies start to decrease. [7] Neutralizing antibodies block the coronavirus spike protein from attaching to human cells. Thus they prevent infection. Once they are low, breakthrough infections start to happen

Antibody-dependent enhancement

When neutralizing antibodies go down, non-neutralizing antibodies stay behind. If SARS-CoV-2 is reencountered, some non-neutralizing antibodies provide protection, but some allow the SARS-CoV-2 to enter a white blood cell called macrophages. There they will multiply and spread all over the body, resulting in a higher viral load with resulting cytokine storm manifesting as multi-system organ failure.

The is called infection enhancement or antibody-dependent enhancement (ADE). That’s the experience of vaccinologists when they tried to make vaccines against the Middle Eastern Respiratory Viruses (MERS) and SARS. The animals developed antibodies when injected with the vaccines, but they all died when exposed to wild-type coronaviruses.

Tip: Early treatment prevents ADE.

In summary, this article illustrates the deficiency of the innate immune system right after the jabs and antibody-dependent enhancement once the neutralizing antibodies decrease months after the shots.

And based on the CDC definition of fully vaccinated, most of the vaccinated will be grouped with the unvaccinated in data reporting.

What happens in Alberta can happen anywhere.

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Related:

References:

https://web.archive.org/web/20220114141053/https://www.alberta.ca/stats/covid-19-alberta-statistics.htm#vaccine-outcomes
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Nance, K. D., and Meier, J. L. (2021). Modifications in an Emergency: The Role of
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Park JW, Lagniton PNP, Liu Y, Xu RH. mRNA vaccines for COVID-19: what, why and how. Int J Biol Sci. 2021;17(6):1446-1460. Published 2021 Apr 10. doi:10.7150/ijbs.59233
Andries O.; Mc Cafferty S.; De Smedt S. C.; Weiss R.; Sanders N. N.; Kitada T. N(1)-Methylpseudouridine-Incorporated mRNA Outperforms Pseudouridine-Incorporated mRNA by Providing Enhanced Protein Expression and Reduced Immunogenicity in Mammalian Cell Lines and Mice. J. Controlled Release 2015, 217, 337–344. 10.1016/j.jconrel.2015.08.051. [PubMed] [CrossRef] [Google Scholar] [Ref list]
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