IgG4 is not increased in Long COVID Syndrome

This article presents a new study showing that IgG4 is not elevated in Long COVID Syndrome.[1]

Long COVID Syndrome

The CDC defines Long COVID, Long Haul COVID, or Post COVID Syndrome as continuing COVID-19 symptoms after four weeks. It can last weeks, months, or even years after infection. Sometimes the symptoms can even go away or come back again.

Fatigue and “brain fog” are among the most-reported long COVID symptoms. Other complaints include insomnia, changes in smell and taste, shortness of breath, chest pain, palpitations, dizziness, depression, and anxiety.[2]

A study by Swank et al. detected SARS-CoV-2 spike proteins in Long Haul patients until 12 months after the infection.[3] That begs the question, do the spike proteins increase the IgG4 in Poct COVID patients? Will the mRNA injections increase IgG4?

mRNA shots increase IgG4

In December 2022 and January 2023, two studies showed that the Pfizer and Moderna mRNA vaccines raised the IgG4 levels after several months. I discussed those papers at:

That is concerning because high levels of IgG4 against SARS-CoV-2 do not get rid of the viruses and tolerate them instead. Thus, it is not surprising that

Three Studies Link High IgG4 to Severe COVID-19

Antibodies are also called immunoglobulins (Ig). Several immunoglobulins exist (G, A, M, D, and E). After an infection, the IgM increases, followed by the IgG.

Antibodies are shaped like the letter Y. The upper part attaches to anything foreign to the body. It can be a bacteria, virus, or fungus.

The bottom part attaches to an effector molecule like the complement system, macrophages, or natural killer cells to destroy whatever the other end of the antibody is linked to. That is what IgG1 and IgG3 do.

IgG2 and IgG4 do not do that. They tolerate antigens like viruses and foreign bodies. That is why IgG4 goes up after allergy desensitization.

In the two studies I referred to earlier that showed that the Pfizer and Moderna mRNA shots increased the IgG4, the authors mentioned that the continued presence of the spike proteins in the germinal centers of the lymphocytes (which do not happen according to Pfizer and Moderna when they were initially released), caused the rise in the IgG4.

The increased IgG4 allowed the continuation of the spike proteins present in the human cells because the RNA of the SARS-CoV-2 can be reverse-transcribed to become a DNA and integrate with the human genome.

SARS-CoV-2 RNA Reverse Transcribed to Human DNA

Therefore, if the spike protein, a foreign body, is persistently present in the cells, it will elicit an inflammatory response and continue to create blood clots.

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And lead to a rise in autoimmune diseases after the COVID injections.

Several scientists from the University of Regensburg, Clinic Donaustauf, Saarland University, and University Hospital Carl Gustav Carus, all in Germany, authored the study, a preprint released two days ago in BioRxiv.

Two groups of people were examined in the study: those with Long COVID and those who were unvaccinated and recovered from COVID-19 completely. Sixty-four subjects were assigned to each group.

The Post COVID and control groups were matched regarding sex, age, and time interval from symptom onset of COVID-19 to serum donation, which took place at a median of seven months post-symptom onset (Inter Quartile Range of 5.0 to 9.0 and 6.5 to 7 months, respectively).

Ten out of 64 Post-COVID patients (15.6%) were vaccinated at the time of serum sampling.

In the studies that showed the rise in IgG4 in the Pfizer and Moderna shots, the levels increased at about five and two months, respectively.[4][5]

Levels of IgG1, IgG2, IgG3, and IgG4 were measured in both groups.

Results

The relative amounts of spike protein-specific IgG subtypes in both groups were comparable. IgG1 was the most frequent, followed by IgG3, IgG2, and IgG4.

The graph below shows that the IgG1, IgG3, and IgG4 are the same in control and Post COVID groups. There is a mild IgG2 decrease among the Post-COVID group.

Source: Abel et al. IgG4 serum levels are not elevated in cases of Post-COVID syndrome. bioRxiv 2023.03.01.530454

The authors explained that the reduced virus-specific IgG2 levels could contribute to the persistence of SARS-CoV-2, causing chronic inflammation in Post-COVID syndrome.

And since the total IgG4 levels are low, it is expected to play no biological role in Post COVID syndrome.

Comment:

The AstraZeneca COVID vaccine was not shown to cause a rise in IgG4. I wonder if that was the COVID injection that the ten Post COVID patients received. If they got Pfizer or Moderna, that might explain the slight rise in the IgG4 graph that was not statistically significant when the whole group was compared to the control.

To conclude, unlike the Pfizer and Moderna COVID injections, the SARS-CoV-2 does not increase IgG4.

High levels of IgG4 are implicated in severe COVID-19 and probably contribute to the side effects of the COVID “vaccines” like autoimmune disorders, thrombus formation, and sudden deaths.

The treatment is worse than the disease.

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Potential Spike Protein Solutions

References:

Abel et al. IgG4 serum levels are not elevated in cases of Post-COVID syndrome. bioRxiv 2023.03.01.530454; doi: https://doi.org/10.1101/2023.03.01.530454
Walter K. An Inside Look at a Post–COVID-19 Clinic. JAMA. 2021;325(20):2036–2037. doi:10.1001/jama.2021.2426
Swank, Z., Senussi, Y., Manickas-Hill, Z., Yu, X.G., Li, J.Z., et al. (2022) Persistent Circulating SARS-CoV-2 Spike Is Associated with Post-Acute COVID-19 Sequelae. Clinical Infectious Diseases, 2022, ciac722. https://doi.org/10.1093/cid/ciac722
Irrgang P, Gerling J, Kocher K, Lapuente D, Steininger P, Habenicht K, et al. Class
switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. Sci Immunol. 2022 Dec 22;eade2798
Buhre JS et al. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine. Front Immunol. 2023 Jan 12;13:1020844.

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