High blood sugar causes Metabolic Memory

This article presents a study that showed that high blood sugar could change macrophages and cause atherosclerosis. The study was published in the journal Circulation in Sept 2021. The authors are from Oxford, UK; the Karolinska Institute in Sweden, the Radboud University in the Netherlands; and the Life and Medical Sciences Institute (LIMES) at the…

A Healthy Lifestyle is as effective as Voglibose and Nateglinide in Lowering 10-year Cardiac Mortality

This article presents two studies that show the superiority of a healthy lifestyle in lowering cardiac-related deaths compared to diabetes medications. And second, the importance of managing early diabetes to prevent cardiovascular deaths. The first study, Effects of voglibose and nateglinide on glycemic status and coronary atherosclerosis in early-stage diabetic patients, or the DIANA (DIAbetes…

Intermittent fasting Reverses Endothelial Dysfunction

This article presents three studies showing intermittent fasting could improve endothelial function. The endothelium is the inner lining of the blood vessels, and the cells in it do a full-time job of keeping it smooth, distensible, and open to maintain adequate organ perfusion, and lower blood pressure, resulting in less work for the heart. The…

After meal blood sugar spikes as a cause of vascular failure

This article is about the damaging effects of high blood sugar on the blood vessels after a meal. Post Prandial Hyperglycemia Post-prandial hyperglycemia (PPH) is the medical term for increased blood sugar after eating. It occurs if the blood sugar is 140 – 200 mg/dl two hours after eating. PPH can damage the arteries. The…

How to Prevent Hyperglycemia with the Vegetables-Meat-Carbs Sequence

This article presents a study that shows how to prevent the rapid rise of blood sugar after a meal or Post-Prandial Glycemia (PPG) After-Meal Blood Sugar and atherosclerosis High blood sugar after meals is a risk factor for developing diabetes and atherosclerosis. It injures the inner lining of the arteries and starts or continues atherosclerosis.[1]…

An Unusual Case of Parkinsonism Improvement After Nattokinase Use

This article was updated with English, Spanish and Mandarin audio on November 21, 2025 🎧 IntroducciΓ³n en audio β€” EspaΓ±ol (LatinoamΓ©rica) En este audio comentaremos un caso clΓ­nico donde una persona con sΓ­ntomas de parkinsonismo experimentΓ³ mejorΓ­a despuΓ©s de usar nattokinasa. Revisaremos quΓ© ocurriΓ³, cΓ³mo se interpretan estos hallazgos y por quΓ© este tipo de…

Laboratory Studies on Nattokinase and Abnormal Protein Aggregates

This article was updated with audio on August 15, 2025. This article discusses research that has shown nattokinase can dissolve amyloid and prion proteins. What are Amyloids and Prions? Both are abnormal proteins because they are misfolded. Proteins in various parts of the body serve multiple functions. Proteins can be structural (bone), related to movement…

Should You Take Nattokinase On An Empty Stomach?

Updated on November 25, 2025, with new English, Latin American Spanish, and Mandarin audio versions to help readers worldwide access this content and a brand new feature, the slideshow. 🎧 ▢️ Press the play button below to listen in English. πŸ‡ͺπŸ‡Έ Spanish (LatinoamΓ©rica) Hoy aprenderΓ‘s si la nattokinasa debe tomarse en ayunas para una mejor…

Natto: An Application of the 80/20 Rule

This article was updated with audio on August 29, 2025. 🎧 ▢️ Press play below to listen. Your browser does not support the audio element. The 80/20 Rule The 80-20 rule, also known as theΒ Pareto Principle, teaches us that a small effort often yields the majority of results. In health, this means just a few…

How I Made and Appreciated Natto

This article discusses how I made my first batch of natto. I figured that with all the health benefits I learned about natto and nattokinase, I would be crazy not to take it. I don’t know any store or restaurant that sells it around my area, so I decided to make my own. It was…

Nattokinase and Stroke Research: Understanding the Evidence

Updated on December 3, 2025, with new Latin American Spanish and Mandarin audio versions to help readers worldwide access this content. 🎧 ▢️ Press the play button below to listen in English. Β πŸ‡ͺπŸ‡Έ Spanish (LatinoamΓ©rica) En este audio descubrirΓ‘s quΓ© dice la evidencia mΓ‘s reciente sobre la nattokinasa y su posible papel en la prevenciΓ³n…

Insulin Resistance and Atherosclerosis and Nattokinase

This article was updated with Mandarin audio on November 20, 2025. About the Author As a physician with decades of experience in internal medicine and emergency medicine, I often manage patients with diabetes, metabolic syndrome, and cardiovascular disease. This article summarizes peer-reviewed research on insulin resistance, atherosclerosis, and nattokinase, aiming to help readers understand the…

Soy Foods Do Not Increase Breast Cancer Risk

This article presents a series of studies showing that soy intake does not increase breast cancer risk. In contrast, the opposite is true. Soy intake lowers the risk of breast cancer. Breast cancer is currently the most common cancer globally, accounting for 12.5% of all new annual cancer cases worldwide. It is the second most…

High-Dose Nattokinase and Its Potential Benefits for Blood Vessel and Lipid Health

Update:This article has been revised and updated on November 21, 2025, to meet current E-E-A-T standards. The information has been reviewed for accuracy, clarity, and medical safety to ensure readers receive high-quality, evidence-based guidance. English audio below. Press play to listen Your browser does not support the audio element. 🎧 Audio Introduction β€” Spanish (LatinoamΓ©rica)…

Nattokinase is Nontoxic with a High Safety Margin

Update:This article has been revised and expanded On November 21, 2025 to strengthen E-E-A-T (Experience, Expertise, Authoritativeness, and Trustworthiness). The content now reflects updated evidence, clearer explanations, and improved safety information to help readers make well-informed decisions. About the AuthorJesse Santiano, M.D., is a retired physician trained in internal medicine and emergency medicine. He now…

Blood Glucose Spike and its Prevention

This article is based on an NHK Japan YouTube video about glucose spikes. A glucose spike or post-prandial hyperglycemia (PPG)Β is the rise of blood sugar to more than 140 mg/dL after a meal. It can happen after every meal. Many may unknowingly have glucose spikes, including those with normal fasting blood sugar and slender. In…

Prebiotics can bring out Reflux

Yesterday I wrote about my experience with gastroesophageal reflux disease (GERD) in The Post Holiday Heartburn. Further readings into the causes of GERD lead me to another reason many may not be aware of. One of my articles about COVID-19, Gut Microbiome Changes even in mild COVID-19 and what to do about it discussed that…

The Post Holiday Heartburn

I want to share with you my experience with the recent holiday celebrations. Years ago, I used to have frequent heartburns. Doctors call it gastroesophageal reflux disease or GERD. I used to take a lot of TUMS or Rolaids. Working in the emergency department, drinking coffee, and having a poor diet did not help either….