A Healthy Lifestyle is as effective as Voglibose and Nateglinide in Lowering 10-year Cardiac Mortality

Posted on by Jesse Santiano, M.D.

This article presents two studies that show the superiority of a healthy lifestyle in lowering cardiac-related deaths compared to diabetes medications. And second, the importance of managing early diabetes to prevent cardiovascular deaths. The first study, Effects of voglibose and nateglinide on glycemic status and coronary atherosclerosis in early-stage diabetic patients, or the DIANA (DIAbetes…

Intermittent fasting Reverses Endothelial Dysfunction

Posted on by Jesse Santiano, M.D.

This article presents three studies showing intermittent fasting could improve endothelial function. The endothelium is the inner lining of the blood vessels, and the cells in it do a full-time job of keeping it smooth, distensible, and open to maintain adequate organ perfusion, and lower blood pressure, resulting in less work for the heart. The…

Walk After Meals to Prevent Sky High Blood Sugars

Posted on by Jesse Santiano, M.D.

This article discusses studies showing that physical activity can lower blood sugar levels after eating. Post-prandial hyperglycemia (PPH) exists if the blood sugar is above normal (hyper).  Post-prandial glycemia (PPG) is the blood sugar (glucose) level after eating (prandial). Different professional diabetes associations have their definitions of PPG. Any value above the normal PPG is post-prandial…

After meal blood sugar spikes as a cause of vascular failure

Posted on by Jesse Santiano, M.D.

This article is about the damaging effects of high blood sugar on the blood vessels after a meal. Post Prandial Hyperglycemia Post-prandial hyperglycemia (PPH) is the medical term for increased blood sugar after eating. It occurs if the blood sugar is 140 – 200 mg/dl two hours after eating. PPH can damage the arteries. The…

How to Prevent Hyperglycemia with the Vegetables-Meat-Carbs Sequence

Posted on by Jesse Santiano, M.D.

This article presents a study that shows how to prevent the rapid rise of blood sugar after a meal or Post-Prandial Glycemia (PPG) After-Meal Blood Sugar and atherosclerosis High blood sugar after meals is a risk factor for developing diabetes and atherosclerosis. It injures the inner lining of the arteries and starts or continues atherosclerosis.[1]…

Multiple Sclerosis after the COVID shots

Posted on by Jesse Santiano, M.D.

This article discusses the multiple sclerosis cases that happened after COVID-19 jabs. Mindy, a reader, asked me to look into Multiple Sclerosis relapses after COVID injections after her daughter developed more MS lesions in her brain after her shots upon advice by her physicians. Below are the search results from VAERS Data on how many…

An Unusual Case of Parkinsonism Improvement After Nattokinase Use

Posted on by Jesse Santiano, M.D.

This article was updated with English, Spanish and Mandarin audio on November 21, 2025 🎧 Introducción en audio — Español (Latinoamérica) En este audio comentaremos un caso clínico donde una persona con síntomas de parkinsonismo experimentó mejoría después de usar nattokinasa. Revisaremos qué ocurrió, cómo se interpretan estos hallazgos y por qué este tipo de…

Laboratory Studies on Nattokinase and Abnormal Protein Aggregates

Posted on by Jesse Santiano, M.D.

This article was updated with audio on August 15, 2025. This article discusses research that has shown nattokinase can dissolve amyloid and prion proteins. What are Amyloids and Prions? Both are abnormal proteins because they are misfolded. Proteins in various parts of the body serve multiple functions. Proteins can be structural (bone), related to movement…

An Unusual Case of Prostate and Vascular Symptom Improvement With Nattokinase

Posted on by Jesse Santiano, M.D.

This article was updated with audio on November 20, 2025. This article concerns a man with severe prostate pain and leg discoloration whose symptoms were relieved with nattokinase. The Problem A man in his mid-60s had two doses of the Pfizer shot in November 2021. He needed it to travel to attend a wedding. After…

Should You Take Nattokinase On An Empty Stomach?

Posted on by Jesse Santiano, M.D.

Updated on November 25, 2025, with new English, Latin American Spanish, and Mandarin audio versions to help readers worldwide access this content and a brand new feature, the slideshow. 🎧 ▶️ Press the play button below to listen in English. 🇪🇸 Spanish (Latinoamérica) Hoy aprenderás si la nattokinasa debe tomarse en ayunas para una mejor…

mRNA Gene Sequencing to diagnose Post-Vaccine Complications

Posted on by Jesse Santiano, M.D.

Yesterday, I posted Cytokine Storms, mRNA changes, and COVID shots. In it, German pathologists could not find the cause of death on four people who suddenly died after getting the second doses of the Pfizer and Moderna mRNA shots.  Fortunately, they ran mRNA gene sequencing and found that all four cases of sudden deaths had upregulated…

Cytokine Storms, mRNA changes and COVID shots

Posted on by Jesse Santiano, M.D.

This article presents a case series from Japan about four people who died due to cytokine storms after the COVID mRNA shots. I also present the possible reasons for how it happened. A cytokine storm is when the immune response goes berserk. We see it in the Syndrome of Inflammatory Immune Response Syndrome (SIRS). SIRS…

Aerobic, Resistance and Combined Exercise Lowers High Blood Pressure

Posted on by Jesse Santiano, M.D.

This article presents a study that showed that different exercises could lower blood pressure similarly. The research was made to answer the question. What exercise is the best to lower blood pressure? Is it aerobic or weight lifting, or should they be combined? Forty-two participants, age 54 ± 11 years, with a resting blood pressure (SBP/DBP) of 137 ± 9/86 ± 6 mmHg…

Fasting Improves Diabetic Kidney Disease

Posted on by Jesse Santiano, M.D.

This article discusses the two studies that showed the improvement of kidney functions in those with diabetes who fasted. An estimated 37 million Americans have Chronic kidney disease (CKD)—more than 1 in 7 U.S. adults. Kidney disease is present in about 1 in 3 people with diabetes and 1 in 5 people with high blood…

How to Stop Bleeding if on Nattokinase

Posted on by Jesse Santiano, M.D.

Nattokinase has anticoagulant properties. If you take nattokinase and have a cut, the bleeding may be more profuse than usual. It is the same as in any other drugs like aspirin or warfarin or newer ones like dabigatran. I have been taking nattokinase 2,000 FU every day since I have been writing about it. One night,…

Natto: An Application of the 80/20 Rule

Posted on by Jesse Santiano, M.D.

This article was updated with audio on August 29, 2025. 🎧 ▶️ Press play below to listen. Your browser does not support the audio element. The 80/20 Rule The 80-20 rule, also known as the Pareto Principle, teaches us that a small effort often yields the majority of results. In health, this means just a few…

How I Made and Appreciated Natto

Posted on by Jesse Santiano, M.D.

This article discusses how I made my first batch of natto. I figured that with all the health benefits I learned about natto and nattokinase, I would be crazy not to take it. I don’t know any store or restaurant that sells it around my area, so I decided to make my own. It was…

Nattokinase and Stroke Research: Understanding the Evidence

Posted on by Jesse Santiano, M.D.

Updated on December 3, 2025, with new Latin American Spanish and Mandarin audio versions to help readers worldwide access this content. 🎧 ▶️ Press the play button below to listen in English.  🇪🇸 Spanish (Latinoamérica) En este audio descubrirás qué dice la evidencia más reciente sobre la nattokinasa y su posible papel en la prevención…

Insulin Resistance and Atherosclerosis and Nattokinase

Posted on by Jesse Santiano, M.D.

This article was updated with Mandarin audio on November 20, 2025. About the Author As a physician with decades of experience in internal medicine and emergency medicine, I often manage patients with diabetes, metabolic syndrome, and cardiovascular disease. This article summarizes peer-reviewed research on insulin resistance, atherosclerosis, and nattokinase, aiming to help readers understand the…