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This article looks at the top 20 COVID-19 vaccine lot numbers from Pfizer, Moderna, and Janssen linked to the highest rates of serious adverse events per million doses administered.
The side effects analyzed include:
- Deaths
- Myocarditis
- Anaphylaxis
- Severe Allergic Reactions
- Serious Adverse Events (SAEs)
All data are sourced from the Vaccine Adverse Event Reporting System (VAERS) and compiled by OpenVAERS. This publicly accessible dashboard extracts and organizes vaccine safety reports submitted to the U.S. government.
⚠️ While VAERS reports do not prove causality, they are an essential tool for detecting safety signals and guiding further investigation and informed decision-making.
This information is provided to support informed consent, help individuals understand batch-specific risks, and encourage transparency around vaccine safety monitoring.
🧬 What Is a Vaccine Lot?
A lot number refers to a specific batch of vaccine manufactured and distributed under the same conditions. If a particular lot is associated with higher adverse events, it raises questions about production, storage, or distribution consistency.
📈 What the Graphs Show
1. Deaths per Million Doses
OpenVAERS graphs show that certain vaccine lots had significantly more reported deaths per million doses:
- Pfizer Lot EL9261 had the highest death rate at over 400 deaths per million doses.
- Moderna Lot 032H20A and Janssen Lot 1802070 also showed death rates exceeding 350/million.
These outliers sharply contrast with other batches with fewer or no reported deaths, even with similar numbers of doses shipped.
📌 Critical Insight: These numbers reflect reported deaths following vaccination, not confirmed causation. However, the clustering of high death reports around certain lot numbers is significant and merits investigation.

📚 Source: OpenVAERS COVID Vaccine Lot Data, Deaths/Million Doses Shipped.
https://openvaers.com/covid-data/vaccine-lots
2. Myocarditis
- Pfizer Lot FD7200 and Moderna Lot 021B21A-1 were linked to the highest myocarditis rates (heart muscle inflammation), nearing 100 cases per million.
- Moderna’s 021B21A-1 and 039K20A top their list
- Janssen had fewer reported myocarditis events overall, but lots 1821281 and 212A21A were top of their category
📌 Key Insight: Myocarditis was commonly reported in mRNA vaccines, especially Moderna. A few lots are clearly outliers with much higher rates.

📚 Source: OpenVAERS, Myocarditis and Anaphylaxis/Million Doses Graphs
3. Anaphylaxis per Million Doses
What Is Anaphylaxis?
Anaphylaxis is a severe, potentially life-threatening allergic reaction that happens very quickly, often within minutes of exposure to an allergen. It is a medical emergency that requires immediate treatment, typically with an epinephrine injection (like an EpiPen) and a call to emergency services.
Common symptoms of anaphylaxis:
- Trouble breathing (due to airway narrowing or throat swelling)
- Low blood pressure
- Rapid or weak pulse
- Skin rash or hives
- Swelling of the face, lips, tongue, or throat
- Nausea, vomiting, or diarrhea
- Dizziness or fainting
- Highest Pfizer lots: EK4178, EH9899
- Moderna: 039K20A-2A and 025J20A
- Janssen: 1802072 and 1805018
📌 Observation: These are immediate allergic reactions that can be life-threatening. Some batches had up to 25 cases/million, again suggesting variability among lots.

4. 🔍 Severe Allergic Reactions per Million Doses
What Is a Severe Allergic Reaction?
A severe allergic reaction refers to any intense allergic response that may not rise to the level of full anaphylaxis but is still serious enough to require medical attention.
Examples of severe allergic reactions:
- Extensive hives or rash
- Swelling that interferes with normal function (like eyes, lips, or hands)
- Moderate breathing difficulty or wheezing
- Persistent vomiting or diarrhea after allergen exposure
Key Differences: Anaphylaxis vs. Severe Allergic Reaction
Feature | Anaphylaxis | Severe Allergic Reaction |
---|---|---|
Speed of onset | Very rapid (seconds to minutes) | Often slower onset |
Airway involvement | Yes — airway swelling, throat closing | Possibly, but usually less intense |
Blood pressure | Often drops dangerously | Usually stable |
Risk of death | High if untreated | Low to moderate |
Requires epinephrine? | Always | Sometimes (based on severity) |
Hospitalization? | Almost always | Depends on symptoms and progression |
Summary
- Anaphylaxis is the most acute and life-threatening allergic reaction.
- Severe allergic reactions can still be dangerous, but may not involve the airway or cardiovascular system to the same extent.
- Both require prompt medical care, but anaphylaxis needs emergency intervention immediately with epinephrine.
- Top lots for severe reactions (Pfizer): EH9899, EK5730, EJ1685
- Moderna: Lots like 039K20A and 011J20A reported the highest per million
- Janssen: 1816024 and 1802070 had the most severe reactions
📌 Key Insight: A few lots had 300+ severe allergic reactions per million doses, which is much higher than expected in typical vaccine safety data. These “spike” lots may have had formulation, storage, or distribution differences.

5. All Serious Adverse Events (SAEs) per Million Doses
“SAEs” include hospitalization, life-threatening illness, disability, or death. Top SAEs/million doses were seen in:
- Top Pfizer lots: EK4178, EK5730, EJ1685
- Top Moderna lots: 052D22A, 030K20A
- Top Janssen lots: 1802070, 1802088
📌 Key Insight: These batches had the most total serious adverse reports, including death, hospitalization, permanent disability, etc. It shows a lot-by-lot variability in safety profiles.
Interestingly, some of these high-SAE lots were not the largest batches shipped, suggesting that volume alone does not explain the spike in events.

📉 6. Adverse Events by Date Shipped
- Most serious adverse events per million occurred in early 2021 for all three brands.
- After Q2 2021, events per million dropped sharply.
📌 Why?
- Likely due to:
- More vulnerable people vaccinated first (e.g., elderly, frail)
- Higher early-dose concentrations
- Better screening/preparation over time
📦 7. Lot Size vs. Reactions
- Most Pfizer lots were large (1–11 million doses)
- Moderna and Janssen had more medium-sized lots (100k–1M)
- Interestingly, Moderna had many lots with 200+ adverse events, even among smaller batches
📌 Observation: Larger lots would naturally yield more reports, but some smaller lots still showed disproportionately high reaction rates.
⚠️ Important Caveats
- VAERS is a passive surveillance system. Reports are submitted by individuals and healthcare professionals, but do not prove causation.
- Factors such as population vulnerability, underreporting, or lot distribution can influence the numbers.
- Still, large differences between lots may indicate real variability worth investigating further.
🧠 Why This Matters: Informed Consent
Every medical intervention—especially one given to healthy individuals—requires informed consent. This includes understanding:
- The known benefits
- The potential risks
- The variability in safety outcomes, including lot-level data
The data from OpenVAERS, while not final proof, raises valid concerns. It underscores the need for transparency from manufacturers and health agencies—and for individuals to be fully informed before consenting to any treatment or intervention.
📢 Call to Action
If this article helped you understand more about vaccine lot variability and potential risks, please share it with others who may benefit. Informed consent is a key pillar of ethical medicine.
For more articles on preventing common chronic diseases without medication, including audio versions, visit DoctorJesseSantiano.com.
🛡️ Disclaimer
This article is intended for informational and educational purposes only. It does not constitute medical advice and should not be used to make or delay decisions about vaccination. If you have questions about vaccine safety or risks, consult a licensed healthcare provider.
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📚 References
- OpenVAERS COVID Vaccine Lot Data:
https://openvaers.com/covid-data/vaccine-lots - U.S. Vaccine Adverse Event Reporting System (VAERS):
https://vaers.hhs.gov/data.html
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