The Devastating Effects of IgG4 after the mRNA COVID shots

This article discusses the adverse health effects of the IgG4 that can develop after mRNA COVID-19 jabs.

Ig stands for immunoglobulin, which is another name for antibodies. There are five major types of immunoglobulins.

They are G, A, M, D, and E, designated as IgG, IgA, IgM, IgD, and IgE.

They have different roles. IgAs are present in body secretions like the mucus in the nose and respiratory and gastrointestinal tract and are a front-line defense against germs. IgEs are involved in allergies and parasitic infections.

The entire function of IgDs are still elusive, but recent studies have shown that IgDs may work with the microbiome in the respiratory mucus and provide immune protection.

IgMs are the earliest to show up in an infection, followed by IgG. IgG is classified into IgG1, IgG2, IgG3 and IgG4.

IgG1 and IgG3 fight infection and cancer, while IgG2 and IgG4 are associated with immune tolerance.

IgG4 and Allergy Treatment

People with life-threatening allergic responses to bee stings and peanut butter are typically recommended to have desensitization shots.

After a series of injections where a bit of the allergen is introduced, the body develops more IgG4 and becomes immune-tolerant to the allergen. The result is that future life-threatening allergic responses become averted.

mRNA COVID shots and IgG4

In a prior article, I wrote about the research that showed that IgG4 increases several months (seven) after the Pfizer mRNA shots.

Pfizer mRNA shots Switch Antibodies to Non-Neutralizing IgG4

As the title says, there is an increase in the IgG4; however, the IgG1 and IgG3 decrease, making the vaccinated person susceptible to a future SARS-CoV-2 infection.

(You will later discover other disturbing conditions associated with IgG4.)

A few months later, another study showed that the Moderna mRNA-1273 COVID injections could also increase the IgG4.

Moderna and Pfizer COVID jabs Increase Anti-inflammatory IgG4

Between the Pfizer and the Moderna mRNA shots, Moderna could produce more IgG4 due to its higher dose of mRNA (100 µg) compared to the BNT162b2 vaccine (30 µg).

SARS-CoV-2 Does not increase IgG4

Another study showed that IgG4 is not increased in Long COVID syndrome, which means that the increase in IgG4 is not due to the SARS-CoV-2 virus and narrows the cause to the mRNA injections.

IgG4 is not increased in Long COVID Syndrome

How antibodies work

During an infection or in the presence of abnormal, pre-cancerous, and cancerous cells, IgG4 works as a marker to identify the unwanted virus, bacteria, and cells by sticking to them.

Once attached, the other parts of the immune system, like the Complement system and the ADCC or Antibody-Dependent Cellular Cytotoxicity, bind to the IgG4.

The resulting immune complex then destroys the disease-causing entity.

So you can imagine anyone with too much IgG4 would have a poor COVID-19 outcome. That is proven by research, and I present them in — Three Studies Link High IgG4 to Severe COVID-19

AstraZeneca COVID shots do not increase IgG4

People with the adenovirus -vectored COVID shots like the AstraZeneca COVID-19 vaccine may sigh relief. The study that identified Moderna as causing an increase in the IgG4 found that the AstraZeneca COVID shot does not do the same.

In May 2023, the journal Vaccines published IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein.[1]

The authors are from the US, Saudi Arabia, Egypt, Canada, and Mexico.

In the article, they cited the work of Moriyama et al., who showed that the IgG4 could exchange heavy and light chains with another IgG4 resulting in the inability to form immune complexes with the Complement System and ADCC failing to provide immune protection. [2]

Source: Moriyama et al. T helper subsets in Sjögren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. J. Autoimmun. **2014**, 51, 81–88.

Effects of High IgG4 from the mRNA shots

Knowing that immune tolerance can happen with higher levels of IgG4, Uversky and colleagues proposed the following could happen after the mRNA jabs.[1]

I listed the articles that I have written about each adverse event.

1. Vulnerability to re-infection with new Omicron subvariants.

High levels of IgG4 make the immune system tolerant to future SARS-CoV-2 infections. How many vaccinated people do you know that have had COVID-19 more than once?

Repeated COVID booster shots Impair Immunity

2. Immune suppression due to impaired interferon signaling. This results in the activation of latent viral, bacterial, and fungal infections and the uncontrolled growth of cancer cells. Examples:

3. Establishing a chronic COVID-19 infection similar to infections by Hepatitis B, Hepatitis C, and HIV.

Proof of this is from the University of Wisconsin in Madison study. Using wastewater analysis, researchers traced SARS-CoV-2 RNA from one individual with chronic COVID-19 infection infected with a strain that started circulating in October 2020. The study was conducted in May 2023.[3]

A person may test negative for COVID from samples in the nose, but the intestines could still have the SARS-CoV-2.

4. The combined immune suppression produced by SARS-CoV-2 infection and by vaccination) could explain aggressive cancers.

Certain cancer patients receiving anti-PD-1 monoclonal antibody treatment have rapid disease progression instead of cancer remission. Notably, the PD-1 antibody belongs to the IgG4 family.

Cancers such as malignant melanoma, extrahepatic cholangiocarcinoma, pancreatic cancer, and esophageal cancer have been linked to plasma B-cell infiltrates that are IgG4-positive.

Personal note: I recently lost a friend to friend to esophageal cancer. She went thru surgery, radiation, and chemotherapy. Then it suddenly recurred and spread rapidly.

There are other reports of rapidly progressing cancer presented by two world-renowned pathologists, Dr. Ute Krüger and Dr. Arne Burkhardt.

5. Repeated vaccination could also lead to auto-immunity.

Researchers have found that repeated antigen administration promotes systemic autoimmunity in mice not prone to spontaneous autoimmune disorders.[1]

Autoimmune diseases have sprung in many vaccinated people.

6. Increased IgG4 levels induced by repeated vaccination could lead to autoimmune myocarditis.

7. IgG4 Related diseases

IgG4-related diseases are a group of disorders named due to numerous IgG4+ plasma cells in damaged tissues and high serum IgG4 concentrations in most cases. IgG4-Related Disease includes:

8. Excess Deaths.

All the re-infections, autoimmune diseases, myocarditis, and cancers could result in higher-than-average deaths.

Large insurance companies have reported excess deaths.

Read about Excess Deaths in Ed Dowd’s book, “Cause Unknown”: The Epidemic of Sudden Deaths in 2021 & 2022

Will everyone with the mRNA shot have problems associated with higher IgG4 levels?

The authors gave their expert opinion:

Finally, these negative outcomes are not expected to affect everyone receiving these mRNA vaccines.

Individuals with genetic susceptibility, immune deficiencies, and comorbidities are probably the most likely to be affected.[1]

Take Away Message

Remember this article if you are considering getting a booster shot for a viral infection with a very low mortality rate.

Truth heals. Lies kill. Don’t Get Sick!

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References:

Uversky, V.N.; Redwan, E.M.; Makis, W.; Rubio-Casillas, A. IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. Vaccines 2023, 11, 991. https://doi.org/10.3390/vaccines11050991
Moriyama, M.; Tanaka, A.; Maehara, T.; Furukawa, S.; Nakashima, H.; Nakamura, S. T helper subsets in Sjögren’s syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. J. Autoimmun. 2014, 51, 81–88.
Shafer et al. Tracing the origin of SARS-CoV-2 Omicron-like spike sequences detected in wastewater.

medRxiv 2022.10.28.22281553; doi: https://doi.org/10.1101/2022.10.28.2228155

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