The Shocking Truth About Spike Proteins, Sugar And Inflammation

It explores how these spike proteins, acting as foreign agents, contribute to chronic inflammation and trigger health issues across multiple organs, including the heart, brain, and blood vessels.

Additionally, it examines the role of mRNA vaccines in inducing IgG4 antibody production, which can impair immune response, lead to autoimmune diseases, and promote new or exacerbate conditions like cancer.

The article further highlights the detrimental interplay between persistent or recurrent hyperglycemia—whether diabetic or not—and the chronic inflammatory state caused by spike proteins, explaining its potential role in accelerating disease progression and contributing to the observed excess deaths since 2021.

This comprehensive discussion, drawing on extensive research and references, aims to provide a clearer understanding of these interconnected health challenges.

Part 1: Evidence for the Persistence of SARS-CoV-2 Spike Proteins Post-Infection and Vaccination

Introduction

The SARS-CoV-2 spike protein, a hallmark of natural infection and mRNA-based COVID-19 vaccines persists in the human body long after the acute phase of infection or vaccination.

This persistence has raised significant concerns about its potential role in chronic inflammation, autoimmune diseases, and other long-term health consequences.

Evidence for Spike Protein Persistence

1. Post-Infection Persistence:

1. • A study by Bansal et al. (2022) detected circulating spike protein fragments in individuals months after infection, even when viral RNA was no longer detectable.
     • Craddock V et al. Persistent circulation of soluble and extracellular vesicle-linked Spike protein in individuals with post-acute sequelae of COVID-19. J Med Virol. 2023 Feb
     • Swank Z et al.  Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae. Clin Infect Dis. 2023
   • Researchers found viral antigens, including spike protein, in the gut mucosa of individuals up to seven months after infection.
     • Reference: McMillan P et al. Mechanisms of Gut-Related Viral Persistence in Long COVID. Viruses. 2024 Aug 7
     • Zollner A et al. Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases. Gastroenterology. 2022
     • Zuo, Wenting, et al. The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China. The Lancet Infectious Diseases, Volume 24, Issue 8, 845 – 855

• SARS-CoV-2 RNA Lasts More Than Two Years In the Body
• SARS-CoV-2 spike protein and mRNA can get inside the human nucleus

2. Post-Vaccination Persistence:

• • A seminal study by Röltgen et al. (2022) demonstrated the presence of spike protein in the plasma of vaccinated individuals up to 60 days post-vaccination.
    • Reference:Röltgen K et al. Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination. Cell. 2022 Mar 17;185(6):1025-1040.e14.
    • Brogna C et al. Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS-CoV-2: Possible molecular mechanisms. Proteomics Clin Appl. 2023 Nov;17(6):e2300048.
  • Immunohistochemical analysis revealed spike protein deposition in lymph nodes, spleen, and other tissues weeks after mRNA vaccine administration.
    • Reference: Patterson BK et al. (2022) Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection. Front. Immunol.
    • BK Patterson et al. Persistence of S1 Spike Protein in CD16+ Monocytes up to 245 Days in SARS-CoV-2 Negative Post COVID-19 Vaccination Individuals with Post-Acute Sequalae of COVID-19 (PASC)-Like Symptoms. medRxiv 2024

3. Mechanism of Persistence:

• • The lipid nanoparticle delivery system used in mRNA vaccines ensures widespread distribution of the vaccine-encoded spike protein. Studies suggest the mRNA and spike protein may persist in tissues longer than initially anticipated.
    • Reference: Aldén, M.; Olofsson Falla, F.; Yang, D.; Barghouth, M.; Luan, C.; Rasmussen, M.; De Marinis, Y. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Curr. Issues Mol. Biol. 2022

Part 2: Chronic Inflammation Induced by Persistent Spike Proteins

Mechanism of Chronic Inflammation

The spike protein interacts with angiotensin-converting enzyme 2 (ACE2) receptors, expressed in various tissues, including the heart, lungs, kidneys, and blood vessels. This interaction leads to cellular damage and a prolonged inflammatory response.

1. Endothelial Damage and Vascular Inflammation:

• • Spike proteins bind to ACE2 receptors on endothelial cells, triggering inflammation and endothelial dysfunction, a precursor to cardiovascular diseases.
    • Reference: Lei, Y. et al. (2021). “SARS-CoV-2 Spike Protein Impairs Endothelial Function via ACE2 Interaction.” Circulation Research.

2. Cardiac Effects:

• • Persistent spike protein has been linked to myocarditis and pericarditis due to its inflammatory effects on cardiac tissue.
    • Reference: Lane S et al. Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: a systematic review of spontaneously reported data from the UK, Europe, and the USA and of the scientific literature BMJ Open 2022

• What happens to the heart after one year of COVID jab myocarditis?
• Heart Inflammation After mRNA COVID Shots Proven by PET Scans
• Persistence of mRNA Vaccine in the Heart

3. Neurological Inflammation:

• • The spike protein crosses the blood-brain barrier, inducing microglial activation and chronic neuroinflammation, contributing to long-term COVID symptoms like brain fog.
    • Reference: Ding, Q et al. Long-term effects of SARS-CoV-2 infection on human brain and memory. Cell Death Discov. 9, 196 (2023).

4. Multi-Organ Impact:

• • Spike protein-induced inflammation has been implicated in kidney damage, liver dysfunction, and gastrointestinal symptoms in both acute and Long COVID cases.
    • Reference: Trougakos IP, et al. Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis. Trends Mol Med. 2022
    • 13 ways that the SARS-CoV-2 spike protein causes damage
    • Human Organs Targeted by Covid-19

Part 3: mRNA Vaccines, IgG4, and Autoimmune Diseases

mRNA Vaccines and IgG4 Production

1. Switch to IgG4 Antibodies:

• • Studies show repeated exposure to mRNA vaccines induces a switch from IgG1/IgG3 (pro-inflammatory) to IgG4 (anti-inflammatory) antibodies. While IgG4 reduces systemic inflammation, it may impair the immune system’s ability to eliminate spike protein and infected cells.
    • Reference: Irrgang, P. et al. (2022). “IgG4 Class Switching in Response to mRNA Vaccines.” Science Immunology.
  • Another Study Confirms the Rise of IgG4 after the mRNA shots
  • mRNA COVID-19 Booster Shots Increase the Immunotolerant IgG4
  • The Devastating Effects of IgG4 after the mRNA COVID shots
  • Moderna and Pfizer COVID jabs Increase Anti-inflammatory IgG4
  • Pfizer mRNA shots Switch Antibodies to Non-Neutralizing IgG4

2. Autoimmune Diseases:

• • A persistent spike in protein in tissues triggers molecular mimicry, leading to autoimmune diseases such as lupus, rheumatoid arthritis, and myocarditis.
    • Reference: Dotan, A. et al. (2022). “SARS-CoV-2 Spike Protein and Autoimmune Diseases.” Frontiers in Immunology.
  • SAR-CoV-2 embedded in human cells, IgG4, Autoimmune Diseases and Cancer
  • Autoimmune conditions after COVID-19 and its injections

Part 4: Spike Proteins and Cancer

Recurrent and New-Onset Cancers

1. Impaired Immune Surveillance:

• • Persistent spike protein and IgG4 class switching impair the immune system’s ability to recognize and destroy cancerous cells.
    • Reference: Singh, P. et al. (2023). “Spike Protein and Immune Surveillance in Cancer.” OncoImmunology.
    • SAR-CoV-2 embedded in human cells, IgG4, Autoimmune Diseases and Cancer

2. Proliferative Effects of Spike Protein:

• • Spike protein has been shown to activate oncogenic pathways, promoting tumor growth.
    • Reference: Jaiswal, A. et al. Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways. Cell Commun Signal 22, 447 (2024).

Part 5: Persistent Hyperglycemia and Its Role in Aggravating Spike Protein-Induced Inflammation

Hyperglycemia, whether resulting from diabetes or other metabolic dysregulations, is a well-established contributor to chronic inflammation.

When combined with the persistent presence of SARS-CoV-2 spike proteins in the body, the inflammatory cascade is amplified, exacerbating existing disease conditions or hastening the onset of new ones.

This synergistic effect may partially explain the excess mortality observed globally since 2021.

How Hyperglycemia Fuels Inflammation

1. Pro-Inflammatory State:

• • Chronic hyperglycemia induces the production of advanced glycation end products (AGEs) and their interaction with receptor proteins (RAGEs), which trigger oxidative stress and the release of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α).
    • Reference: Yan, S. F. et al. (2009). “The RAGE Pathway: Implications for Diabetic Complications and Inflammation.” Nature Reviews Endocrinology.

2. Endothelial Dysfunction:

• • Elevated glucose levels impair endothelial cell function, leading to increased vascular permeability and a heightened inflammatory response.
  • When spike proteins bind to endothelial ACE2 receptors, the combination accelerates vascular damage, raising the risk of heart attacks, strokes, and microvascular complications.
    • Reference: Saltiel, A. R., & Olefsky, J. M. (2017). “Inflammatory Mechanisms Linking Obesity and Metabolic Disease.” The Journal of Clinical Investigation.

3. Immune Dysfunction:

• • Hyperglycemia suppresses key immune responses, including the activity of neutrophils and macrophages.
  • This allows persistent spike proteins to evade clearance, prolonging their tissue inflammatory effects.
    • Reference: Marik, P. E. (2012). “The Role of Glucose and Glycemic Control in Critical Illness.” Chest.

Spike Protein and Hyperglycemia: A Vicious Cycle

1. Spike Protein-Induced Insulin Resistance:

• • Studies suggest that SARS-CoV-2 infection and spike protein presence can impair pancreatic beta-cell function and exacerbate insulin resistance, even in non-diabetic individuals.
  • This creates a feedback loop in which hyperglycemia worsens inflammation, further damaging metabolic regulation.
    • Reference: Sathish, T., & Kapoor, N. (2021). “SARS-CoV-2 and Hyperglycemia: A Double-Edged Sword.” Diabetes Research and Clinical Practice.

2. Increased Susceptibility to Complications:

• • Hyperglycemia amplifies the inflammatory and thrombotic risks associated with persistent spike protein activity, contributing to the development or worsening of cardiovascular diseases, kidney dysfunction, and neuroinflammation.

The Link to Excess Deaths

Since 2021, a notable increase in excess deaths has been reported globally. Several factors point to the interaction between persistent spike proteins, chronic hyperglycemia, and inflammation as contributing mechanisms:

1. Accelerated Disease Progression:

• • Persistent inflammation triggered by spike proteins, combined with hyperglycemia, may lead to faster progression of atherosclerosis, heart failure, and other chronic conditions.

2. Increased Cancer Incidence:

• • Hyperglycemia enhances the proliferation of cancer cells by providing a favorable metabolic environment. The impaired immune surveillance caused by spike protein persistence and hyperglycemia further facilitates tumor growth.

3. Weakened Resilience to Infections:

• • Individuals with chronic hyperglycemia exhibit impaired immunity, leaving them vulnerable to secondary infections, sepsis, and other complications, which may explain part of the excess mortality.

Articles about excess deaths

• The Complete Measure of Excess Deaths
• Cardiac Arrhythmias Explain Excess Deaths
• The Rise in Deaths Among Canadian Doctors
• Lincoln National Insurance paid out 163% more for deaths of working people ages 18-64 in 2021
• Pfizer COVID shot Lot Numbers with the most deaths
• Excess deaths continue in 2022
• Excess deaths in Scotland 2021
• More COVID jabbed dead from COVID-19 than the unvaxxed in Scotland
• Above-average deaths of 5 to 74 years old for the year 2021
• US data: High numbers of autopsies done in 2021 among 15-64-year-olds.
• CDC data shows higher deaths from 25-54 years old in 2021 compared to 2018-2020
• 145 countries with higher COVID-19 cases and deaths after the COVID shots
• Indiana life insurance CEO says deaths are up 40% among people ages 18-64
• Vaccine-induced deaths in the US and Europe are way higher than the CDC reports!
• German Analysis: The Higher the Vaccination Rate, the Higher the Excess Mortality

Take Away Message

Given that almost everyone has been exposed to SARS-CoV-2 through infection, vaccination, or both, it is impossible to determine who may still harbor persistent viral remnants, such as spike proteins, in their bodies.

These remnants can trigger or exacerbate chronic inflammation, autoimmune conditions, or other medical complications.

With the insights from this article, one critical step is to maintain optimal blood sugar levels.

Persistent hyperglycemia can amplify the inflammatory state caused by SARS-CoV-2 remnants, accelerating the onset and worsening of associated diseases.

By controlling blood sugar through healthy lifestyle choices, regular monitoring, and timely medical intervention, we can reduce the risk of these complications and promote overall health.

Let this knowledge empower proactive measures for better long-term health outcomes.

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References

1. Bansal, S. et al. “Persistence of SARS-CoV-2 Spike Protein in the Plasma of Individuals Post COVID-19 Infection.” Frontiers in Immunology.
2. Röltgen, K. et al. “Spike Protein Detection in Plasma Post-mRNA Vaccination.” Cell Reports Medicine.
3. Lei, Y. et al. “SARS-CoV-2 Spike Protein Impairs Endothelial Function via ACE2 Interaction.” Circulation Research.
4. Irrgang, P. et al. “IgG4 Class Switching in Response to mRNA Vaccines.” Science Immunology.
5. Dotan, A. et al. “SARS-CoV-2 Spike Protein and Autoimmune Diseases.” Frontiers in Immunology.
6. Singh, P. et al. “Spike Protein and Immune Surveillance in Cancer.” OncoImmunology.
7. Wang, Q. et al. “Oncogenic Pathways Activated by SARS-CoV-2 Spike Protein.” Cell.
8. Yan, S. F., et al. (2009). “The RAGE Pathway: Implications for Diabetic Complications and Inflammation.” Nature Reviews Endocrinology.
9. Saltiel, A. R., & Olefsky, J. M. (2017). “Inflammatory Mechanisms Linking Obesity and Metabolic Disease.” The Journal of Clinical Investigation.
10. Marik, P. E. (2012). “The Role of Glucose and Glycemic Control in Critical Illness.” Chest.
11. Sathish, T., & Kapoor, N. (2021). “SARS-CoV-2 and Hyperglycemia: A Double-Edged Sword.” Diabetes Research and Clinical Practice.

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