This article was updated with audio on November 20, 2025.
This article concerns a man with severe prostate pain and leg discoloration whose symptoms were relieved with nattokinase.
The Problem
A man in his mid-60s had two doses of the Pfizer shot in November 2021. He needed it to travel to attend a wedding. After that, he started to have lower abdominal and prostate pain. The prostate sits below the urinary bladder.
He had no burning with urination, and there was no urinary hesitancy.
On top of that, his right leg became dark to the point that it was eggplant colored. There was no pain or swelling in the right leg. No problem with the left.
He saw a urologist and was diagnosed with inflammation of the prostate (prostatitis) and prescribed antibiotics. There was no enlargement of the prostate, but there was tenderness.
The pain continued for over a year, an ultrasound, CT scan of the abdomen and pelvis, urine analysis, colonoscopy, and blood tests were done, and all came back normal.
A urine test was done repeatedly. He was prescribed antibiotics and pyridium, a painkiller for the bladder, but nothing helped.
The lower abdominal pain was 8 out of ten at its height, with ten as the maximum he could tolerate. The discomfort kept waking him up at night. He also had to get up every two hours at night because of his urge to urinate.
Acetaminophen (Tylenol) only works for a couple of hours. His appetite and mood became affected. He looked sad most of the time. He was not eating enough because he was concerned that certain foods may be causing his pain.
He lost a lot of weight. At one time, I suspected he might be developing Parkinson’s disease because he had no facial expression.
The discolored right leg had an arterial and venous doppler. There were no blood clots in the arteries and no deep venous thrombosis. He even saw a vascular doctor who could not identify the problem. I measured the circumference of both legs, and the right leg is smaller by more than 2 cm (∼1 inch). I noticed a limp when he walked.
He could not take aspirin to thin his blood and ibuprofen (Advil, Motrin), a painkiller and anti-inflammatory, because of gastric reflux problems.
Patients like these can frustrate any doctor. Sometimes, they are labeled as hypochondriacs, attention-seeking, or drug-seeking and elicit feelings of apathy, contempt, and scorn from the medical staff. Medical bills can also pile up quickly.
The Spike Protein
I watched the presentation of Dr. Arne Burkhardt about spike proteins in the internal organs prostate of the deceased that he autopsied. Among the organs is the prostate.
A photo of a prostate stained to identify the spike proteins from Dr. Burkhardt’s presentation is reproduced below. The stain Dr. Burkhardt is an innovation I have not seen in other autopsy studies.
The brown areas are spike proteins. There should be none.
I discussed his presentation in New and Alarming Autopsy Findings after the COVID shots.
Clarifying the Science Behind Spike Protein Research
To give you more context about studies on spike protein detection in tissues and enzymatic degradation for transparency and accuracy:
- Some autopsy findings and in vitro studies highlight possible tissue-level inflammatory responses to viral or vaccine-related spike protein exposure.
- These findings vary in methodology, are not uniform across studies, and are still actively debated in the scientific community.
- Observations from case reports cannot establish causation but can provide material for scientific discussion.
Spike proteins produced in the body
The mRNA in the Pfizer shot, and Moderna shots can reverse transcribed into DNA by LINE-1 (Long interspersed nuclear elements (LINE-1) and become part of human DNA. Once in the DNA, the body can make spike proteins.
I discussed the research paper demonstrating that spike mRNA can integrate into human DNA at SARS-CoV-2 RNA Reverse Transcribed to Human DNA.
Being a foreign substance, the spike protein in the body elicits an immune response and inflammation. Pain is one sign of inflammation. The others are redness, swelling, and warmth. Thus it is conceivable that his prostate pain is from the presence of the spike protein.
The spike proteins are also attracted to the ACE2 receptors in the blood vessels to cause inflammation and clot formation. It is possible that the slow venous drainage in the right leg caused the red blood cell to come out of the vines and deposit in the skin.
Experiments showing reverse transcription in cell cultures demonstrate a biochemical possibility under laboratory conditions, not proven DNA integration in humans.
Human biology is more complex than isolated cell-line studies.
Readers should understand the distinction between experimental findings and confirmed physiological events.
Poor venous return can explain the subject’s lower abdominal and prostate pain and leg ruddiness.
mRNA COVID shots have been associated with vascular problems.
- Four ways the spike protein rapidly forms blood clots resistant to break down
- Two More Ways the Spike Proteins Produce Abnormal Blood Clots
- This study shows Ten Fold risk of Developing Blood Clots after the COVID Vaccines.
- Platelet Changes Cause Blood Clots in COVID-19
- The High Risk of Deadly Brain Clots in the J & J COVID Vaccine
Nattokinase
Around that time, I already wrote Nattokinase Degrades the SARS-CoV-2 Spike Protein, and Another Study shows Nattokinase can Destroy the S1 Spike Protein.
Both studies show that nattokinase, an enzyme that can degrade protein linkages, can break up spike proteins.
I recommended nattokinase to him, and he took it at 2,000 FU a day for about a week. FU stands for Fibrin Units or Fibrin Degradation Units. It is the amount of nattokinase enzymatic activity typically in a 100 mg capsule.
Improvement
He started the nattokinase in the middle of February. Yesterday, I asked him how are the pain and this time; it is now 3 out of ten. That’s a remarkable change.
He can sleep better now, and the times he has to get up to go to the bathroom have dropped to two, which was his baseline.
He said his symptoms improved one week after starting the nattokinase. He did not change the dose and is not taking other medicines or supplements.
The image below shows his right leg’s color improvement after two weeks of nattokinase. Note that it was eggplant-colored before.
This morning, five weeks after nattokinase, both legs are almost the same color.
After a long time, I heard him laugh again. He did not complain of any side effects.
The brand that he used is Doctor’s Best Natto-Serra. It contains 2,000 FU of nattokinase and 40,000 SPU of Serrapeptase enzyme. Serratiopeptidase is an enzyme from the Serratia species and, like nattokinase, has anticoagulant properties and anti-inflammatory activities.
The use of a combined nattokinase and serrapeptase adds a twist to the management of mRNA shot complications. Is nattokinase enough, or does serrapeptase have to be added?
What we know from research:
- Nattokinase is a serine protease with demonstrated effects on fibrin degradation, circulation, and viscosity.
- Laboratory studies have shown that nattokinase can degrade certain proteins, including spike protein in vitro.
- Human studies suggest benefits for blood flow, blood pressure, and clot breakdown.
What we do not yet know:
- Whether nattokinase can reliably degrade spike proteins inside the human body in a clinically meaningful way.
- Whether nattokinase consistently improves prostate or vascular problems across larger populations.
- What the optimal dose, duration, or combination (e.g., with serrapeptase) should be in complex inflammatory or post-infectious conditions.
Why the improvement still matters:
Case reports like this one are important because they:
- Highlight patterns clinicians may observe in practice.
- Generate hypotheses for future research.
- Offer hope to patients with limited options.
Supplement Safety
Important Safety Notes
- Nattokinase and serrapeptase have anticoagulant properties.
- They may increase bleeding risk, especially when combined with:
- warfarin
- DOACs (e.g., apixaban, rivaroxaban)
- aspirin
- other blood-thinning supplements
- Vitamin K2 in natto-derived supplements may interfere with warfarin.
- People with ulcers, recent surgery, bleeding disorders, or anticoagulant use must avoid nattokinase unless supervised by a physician.
This case is encouraging, but it represents an individual response. Supplements should always be used under medical guidance, especially in people with vascular or bleeding-related conditions.
How did nattokinase help him?
As presented above, nattokinase is an enzyme that can degrade the spike protein. Nattokinase Degrades the SARS-CoV-2 Spike Protein, and Another Study shows Nattokinase can Destroy the S1 Spike Protein.
Nattokinase has anticoagulant (prevents blood clot formation) and anti-fibrinolytic (dissolves blood clots) properties.
Nattokinase solved the problem by taking care of the spike protein, which is the cause of the problem, and removing and reversing the disease mechanism (blood clots).
Read more about it at The Outstanding Vascular Effects and Dose of Nattokinase
Context: Why This Case Is Clinically Important
Chronic pelvic pain and unexplained vascular discoloration are frustrating for patients and medical teams alike. The case presented in this article is notable because:
- Standard evaluations (ultrasound, CT, colonoscopy, blood tests) were unrevealing.
- Symptoms spanned multiple systems: prostate pain, urinary symptoms, sleep disruption, weight loss, leg discoloration, and functional decline.
- Conventional treatments (antibiotics, pyridium, analgesics) did not provide relief.
This complexity makes it reasonable—and medically appropriate—to explore biological mechanisms, including inflammatory pathways and vascular factors, that may connect these symptoms.
Improvement in a single case cannot prove that nattokinase caused the recovery.
Spontaneous resolution, delayed healing, or multifactorial changes cannot be excluded.
However, the timing, symptom pattern, and vascular improvements make the enzyme a plausible contributor worth studying further.
DO NOT TAKE NATTOKINASE IF ON WARFARIN (COUMADIN, JANTOVIA). tHE VITAMIN K2 CAN BLOCK THE BLOOD THINNING EFFECT AND LEAD TO BLOOD CLOTTING.
Always ask your doctor before taking any supplements.
Part 2 of this case report addresses how Nattokinase resolved his Parkinsonism at Parkinsonism resolved by Nattokinase
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Related:
- Bromelain and Acetylcysteine Combined Destroy SARS-CoV-2 spike protein
- Nattokinase Degrades the SARS-CoV-2 Spike Protein
- Another Study shows Nattokinase can Destroy the S1 Spike Protein
- How to dose Nattokinase, Bromelain, and NAC
- Intermittent fasting results in new and stress-resistant blood cells
- Intermittent fasting for Post COVID Vaccine Syndrome: Autophagy
- The I-RECOVER Post-Vaccine Treatment Protocol
- The I-RECOVER Management Protocol for Long Haul COVID-19 Syndrome
- Over The Counter Ivermectin
- Should you take nattokinase on an empty stomach?
- How to stop bleeding if on nattokinase
- Natto: An application of the 80-20 Rule
- How I Made and Appreciated Natto
- Insulin Resistance and Atherosclerosis and the Nattokinase Solution
- Protective Effects of Nattokinase against Strokes
- High-Dose Nattokinase to Shrink Atherosclerosis and Lower Blood Lipids
- Nattokinase is Nontoxic with a High Safety Margin
- The Outstanding Vascular Effects and Dose of Nattokinase
- Soy Foods Do Not Increase Breast Cancer Risk
- Inflammation: Dolor, Tumor, Rubor, and Calor.
References:
You may append these after your “References” section:
- Weng Y, Yao J, Sparks S, Wang KY. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28;18(3):523. doi: 10.3390/ijms18030523. PMID: 28264497; PMCID: PMC5372539. https://pmc.ncbi.nlm.nih.gov/articles/PMC5372539/
- Hsia, Chin-Hua, et al. “Nattokinase Decreases Plasma Levels of Fibrinogen, Factor VII, and Factor VIII in Human Subjects.” Nutrition Research, vol. 29, 2009. https://pubmed.ncbi.nlm.nih.gov/19358933/
- Mei, Jian & Cai, Shao & Yi, Yu & Wang, Xu & Ying, Guo. (2022). Study of the fibrinolytic activity of serrapeptase and its in vitro thrombolytic effects. Brazilian Journal of Pharmaceutical Sciences. 58. 10.1590/s2175-97902022e201004.
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